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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37TyrosineUniRule annotation1 Publication1
Binding sitei168TyrosineUniRule annotation1 Publication1
Binding sitei172TyrosineUniRule annotation1 Publication1
Binding sitei175TyrosineUniRule annotation1 Publication1
Binding sitei190TyrosineUniRule annotation1 Publication1
Binding sitei254ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-984-MONOMER
BRENDAi6.1.1.1 5244

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:PH1011
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002402691 – 375Tyrosine--tRNA ligaseAdd BLAST375

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi70601.PH1011

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 11Combined sources9
Beta strandi15 – 19Combined sources5
Helixi21 – 30Combined sources10
Beta strandi35 – 40Combined sources6
Helixi48 – 63Combined sources16
Beta strandi69 – 72Combined sources4
Helixi74 – 79Combined sources6
Helixi82 – 85Combined sources4
Helixi87 – 96Combined sources10
Helixi98 – 108Combined sources11
Helixi113 – 115Combined sources3
Beta strandi116 – 120Combined sources5
Helixi122 – 125Combined sources4
Helixi128 – 138Combined sources11
Helixi143 – 148Combined sources6
Helixi149 – 153Combined sources5
Helixi164 – 178Combined sources15
Beta strandi182 – 187Combined sources6
Helixi188 – 190Combined sources3
Helixi191 – 200Combined sources10
Helixi201 – 203Combined sources3
Beta strandi205 – 207Combined sources3
Beta strandi209 – 211Combined sources3
Beta strandi214 – 216Combined sources3
Beta strandi219 – 223Combined sources5
Beta strandi233 – 236Combined sources4
Helixi240 – 250Combined sources11
Helixi252 – 254Combined sources3
Helixi257 – 259Combined sources3
Helixi267 – 276Combined sources10
Helixi288 – 295Combined sources8
Turni296 – 298Combined sources3
Beta strandi299 – 302Combined sources4
Beta strandi305 – 307Combined sources3
Helixi311 – 313Combined sources3
Beta strandi317 – 321Combined sources5
Helixi322 – 330Combined sources9
Helixi336 – 350Combined sources15
Helixi352 – 360Combined sources9
Helixi363 – 370Combined sources8

3D structure databases

ProteinModelPortaliO58739
SMRiO58739
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58739

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi251 – 255"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01886 Archaea
COG0162 LUCA
HOGENOMiHOG000228238
KOiK01866
OMAiYIGFEIS
OrthoDBiPOG093Z05HU

Family and domain databases

CDDicd00805 TyrRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_02009 Tyr_tRNA_synth_type4, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002307 Tyr-tRNA-ligase
IPR023678 Tyr-tRNA-ligase_4
IPR023617 Tyr-tRNA-ligase_arc/euk-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PIRSFiPIRSF006588 TyrRS_arch_euk, 1 hit

Sequencei

Sequence statusi: Complete.

O58739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEERINLV LKKPTEEVLT VENLRHLFEI GAPLQHYIGF EISGYIHLGT
60 70 80 90 100
GLMAGAKIAD FQKAGIKTRV FLADWHSWIN DKLGGDLEVI QEVALKYFKV
110 120 130 140 150
GMEKSIEVMG GDPKKVEFVL ASEILEKGDY WQTVIDISKN VTLSRVMRSI
160 170 180 190 200
TIMGRQMGEA IDFAKLIYPM MQVADIFYQG VTIAHAGMDQ RKAHVIAIEV
210 220 230 240 250
AQKLRYHPIV HEGEKLKPVA VHHHLLLGLQ EPPKWPIESE EEFKEIKAQM
260 270 280 290 300
KMSKSKPYSA VFIHDSPEEI RQKLRKAFCP AREVRYNPVL DWVEYIIFRE
310 320 330 340 350
EPTEFTVHRP AKFGGDVTYT TFEELKRDFA EGKLHPLDLK NAVAEYLINL
360 370
LEPIRRYFEK HPEPLELMRS VKITR
Length:375
Mass (Da):43,276
Last modified:August 1, 1998 - v1
Checksum:i8A4BC945037A9F1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30108.1
PIRiF71093
RefSeqiWP_010885097.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30108; BAA30108; BAA30108
GeneIDi1443332
KEGGipho:PH1011

Similar proteinsi

Entry informationi

Entry nameiSYY_PYRHO
AccessioniPrimary (citable) accession number: O58739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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