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Protein

Translation initiation factor 2 subunit alpha

Gene

eif2a

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-936-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit alpha
Alternative name(s):
aIF2-alpha
eIF-2-alpha
Gene namesi
Name:eif2a
Ordered Locus Names:PH0961
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374001 – 275Translation initiation factor 2 subunit alphaAdd BLAST275

Proteomic databases

PRIDEiO58655

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi70601.PH0961

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 23Combined sources10
Beta strandi26 – 31Combined sources6
Beta strandi38 – 42Combined sources5
Helixi43 – 45Combined sources3
Helixi54 – 56Combined sources3
Beta strandi63 – 72Combined sources10
Turni73 – 76Combined sources4
Beta strandi77 – 82Combined sources6
Helixi87 – 114Combined sources28
Helixi118 – 124Combined sources7
Helixi126 – 133Combined sources8
Helixi136 – 146Combined sources11
Helixi148 – 151Combined sources4
Helixi157 – 159Combined sources3
Helixi160 – 170Combined sources11

3D structure databases

ProteinModelPortaliO58655
SMRiO58655
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO58655

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 83S1 motifAdd BLAST72

Sequence similaritiesi

Belongs to the eIF-2-alpha family.Curated

Phylogenomic databases

eggNOGiarCOG04107 Archaea
COG1093 LUCA
HOGENOMiHOG000224965
KOiK03237
OMAiKDVNEHQ
OrthoDBiPOG093Z07K6

Family and domain databases

Gene3Di1.10.150.190, 1 hit
3.30.70.1130, 1 hit
HAMAPiMF_00231 eIF_2_alpha, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022967 S1_dom
IPR003029 S1_domain
IPR022964 TIF2_asu_arc
IPR024055 TIF2_asu_C
IPR024054 TIF2_asu_middle_sf
IPR011488 TIF_2_asu
PANTHERiPTHR10602 PTHR10602, 1 hit
PfamiView protein in Pfam
PF07541 EIF_2_alpha, 1 hit
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF110993 SSF110993, 1 hit
SSF116742 SSF116742, 1 hit
SSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

O58655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKAREYPE EGEFVVATVK RIHNYGAFLE LDEYPGKEAF MHISEVASTW
60 70 80 90 100
VRNIRDYLKE GQKVVAKVIR VDPRKGHIDL SLRRVTQQQR KAKLQEFKRA
110 120 130 140 150
QKAENLLRLA AEKLGKDFEA AWREVWVPLE EEWGEVYAAF EDAAKDGIEV
160 170 180 190 200
LKGHVPDEWL PVLKEIVENY VEVPTVTIDA EFEITVPKPN GVEIIKEALI
210 220 230 240 250
RARDRANKEK DIEVKFTYQG APRYRIDITA PDYYKAEEVL EDIAEEILRV
260 270
IKQAGGEATL LRKEKRIRKV KKRKK
Length:275
Mass (Da):31,980
Last modified:August 1, 1998 - v1
Checksum:i6AAAD15F10FFB436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30058.1
PIRiD71087
RefSeqiWP_010885052.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30058; BAA30058; BAA30058
GeneIDi1443287
KEGGipho:PH0961

Similar proteinsi

Entry informationi

Entry nameiIF2A_PYRHO
AccessioniPrimary (citable) accession number: O58655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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