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UniProtKB - O58655 (IF2A_PYRHO)
Protein
Translation initiation factor 2 subunit alpha
Gene
eif2a
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Functioni
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
By similarityGO - Molecular functioni
- translation initiation factor activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Initiation factor, RNA-binding |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Translation initiation factor 2 subunit alphaAlternative name(s): aIF2-alpha eIF-2-alpha |
Gene namesi | Name:eif2a Ordered Locus Names:PH0961 |
Organismi | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
Taxonomic identifieri | 70601 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000137400 | 1 – 275 | Translation initiation factor 2 subunit alphaAdd BLAST | 275 |
Interactioni
Subunit structurei
Heterotrimer composed of an alpha, a beta and a gamma chain.
By similarityProtein-protein interaction databases
STRINGi | 70601.3257375 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | O58655 |
SMRi | O58655 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O58655 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 83 | S1 motifAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the eIF-2-alpha family.Curated
Phylogenomic databases
eggNOGi | arCOG04107, Archaea |
OMAi | DVNEHQR |
OrthoDBi | 84684at2157 |
Family and domain databases
CDDi | cd04452, S1_IF2_alpha, 1 hit |
Gene3Di | 1.10.150.190, 1 hit 2.40.50.140, 1 hit 3.30.70.1130, 1 hit |
HAMAPi | MF_00231, eIF_2_alpha, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022967, S1_dom IPR003029, S1_domain IPR044126, S1_IF2_alpha IPR022964, TIF2_asu_arc IPR024055, TIF2_asu_C IPR024054, TIF2_asu_middle_sf IPR011488, TIF_2_asu |
PANTHERi | PTHR10602, PTHR10602, 1 hit |
Pfami | View protein in Pfam PF07541, EIF_2_alpha, 1 hit PF00575, S1, 1 hit |
SMARTi | View protein in SMART SM00316, S1, 1 hit |
SUPFAMi | SSF110993, SSF110993, 1 hit SSF116742, SSF116742, 1 hit SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS50126, S1, 1 hit |
i Sequence
Sequence statusi: Complete.
O58655-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRKAREYPE EGEFVVATVK RIHNYGAFLE LDEYPGKEAF MHISEVASTW
60 70 80 90 100
VRNIRDYLKE GQKVVAKVIR VDPRKGHIDL SLRRVTQQQR KAKLQEFKRA
110 120 130 140 150
QKAENLLRLA AEKLGKDFEA AWREVWVPLE EEWGEVYAAF EDAAKDGIEV
160 170 180 190 200
LKGHVPDEWL PVLKEIVENY VEVPTVTIDA EFEITVPKPN GVEIIKEALI
210 220 230 240 250
RARDRANKEK DIEVKFTYQG APRYRIDITA PDYYKAEEVL EDIAEEILRV
260 270
IKQAGGEATL LRKEKRIRKV KKRKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000001 Genomic DNA Translation: BAA30058.1 |
PIRi | D71087 |
RefSeqi | WP_010885052.1, NC_000961.1 |
Genome annotation databases
EnsemblBacteriai | BAA30058; BAA30058; BAA30058 |
GeneIDi | 1443287 |
KEGGi | pho:PH0961 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000001 Genomic DNA Translation: BAA30058.1 |
PIRi | D71087 |
RefSeqi | WP_010885052.1, NC_000961.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3AEV | X-ray | 2.80 | A | 1-275 | [»] | |
AlphaFoldDBi | O58655 | |||||
SMRi | O58655 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 70601.3257375 |
Genome annotation databases
EnsemblBacteriai | BAA30058; BAA30058; BAA30058 |
GeneIDi | 1443287 |
KEGGi | pho:PH0961 |
Phylogenomic databases
eggNOGi | arCOG04107, Archaea |
OMAi | DVNEHQR |
OrthoDBi | 84684at2157 |
Miscellaneous databases
EvolutionaryTracei | O58655 |
Family and domain databases
CDDi | cd04452, S1_IF2_alpha, 1 hit |
Gene3Di | 1.10.150.190, 1 hit 2.40.50.140, 1 hit 3.30.70.1130, 1 hit |
HAMAPi | MF_00231, eIF_2_alpha, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022967, S1_dom IPR003029, S1_domain IPR044126, S1_IF2_alpha IPR022964, TIF2_asu_arc IPR024055, TIF2_asu_C IPR024054, TIF2_asu_middle_sf IPR011488, TIF_2_asu |
PANTHERi | PTHR10602, PTHR10602, 1 hit |
Pfami | View protein in Pfam PF07541, EIF_2_alpha, 1 hit PF00575, S1, 1 hit |
SMARTi | View protein in SMART SM00316, S1, 1 hit |
SUPFAMi | SSF110993, SSF110993, 1 hit SSF116742, SSF116742, 1 hit SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS50126, S1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IF2A_PYRHO | |
Accessioni | O58655Primary (citable) accession number: O58655 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- Translation initiation factors
List of translation initiation factor entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families