Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-amylase

Gene

amyA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei123NucleophileBy similarity1
Active sitei214Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-183-MONOMER

Protein family/group databases

CAZyiGH57 Glycoside Hydrolase Family 57

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylase (EC:3.2.1.1)
Gene namesi
Name:amyA
Ordered Locus Names:PH0193
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001845741 – 633Alpha-amylaseAdd BLAST633

Proteomic databases

PRIDEiO57932

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0193

Structurei

3D structure databases

ProteinModelPortaliO57932
SMRiO57932
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 57 family.Curated

Phylogenomic databases

eggNOGiarCOG03280 Archaea
COG1449 LUCA
HOGENOMiHOG000223207
KOiK22451
OMAiHFMSAGL
OrthoDBiPOG093Z00N7

Family and domain databases

Gene3Di2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR015179 A-amylase/a-glucTrfase_C
IPR015178 A-amylase/a-glucTrfase_central
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR028995 Glyco_hydro_57/38_cen_sf
IPR004300 Glyco_hydro_57_N
PfamiView protein in Pfam
PF09094 DUF1925, 1 hit
PF09095 DUF1926, 1 hit
PF03065 Glyco_hydro_57, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014405 DUF1925, 1 hit
SUPFAMiSSF74650 SSF74650, 1 hit
SSF88688 SSF88688, 1 hit
SSF88713 SSF88713, 1 hit

Sequencei

Sequence statusi: Complete.

O57932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRINFIFGV HNHQPLGNFE WIIKRAYEKA YRPFLETLEE YPNMKVAVHI
60 70 80 90 100
SGVLVEWLER NRPEYIDLLK SLIKKGQVEL VVAGFYEPIL VAIPEEDRVE
110 120 130 140 150
QIKLSKGWAR KMGYEARGLW LTERVWEPEL VKTLREAGIE YVILDDYHFM
160 170 180 190 200
SAGLSKEELF WPYYTENGGE AIVVFPIDEK LRYLIPFRPV NETLEYLHSL
210 220 230 240 250
ADEDESKVAV FHDDGEKFGA WPGTHELVYE RGWLKEFFDR ISSDDKINLM
260 270 280 290 300
LYSEYLSKFR PKGLVYLPIA SYFEMSEWSL PARQAKLFFE FIKKLKELNL
310 320 330 340 350
FEKYRIFVRG GIWKNFLYKY PEGNYMHKRM LMLSKLLRNN PTARIFVLRA
360 370 380 390 400
QCNDAYWHGV FGGIYLPHIR RAVWRNLIKA HSYLEPENRV FDLDFDGGEE
410 420 430 440 450
IMLENENFIL VVKPHYGGAI FEMSSKKKYV NYLDVVARRW EHYHSLKDIP
460 470 480 490 500
EGMKRELSYD KWPRGMLQDH FLLPTEVLDN YMLSKYRELG DFLMSSYHYQ
510 520 530 540 550
IEDKLRLWRS GKVKGISVEV EKVLRLNKDG FTTEYRIVSK EELGLMFGVE
560 570 580 590 600
INLAVQGTVE YPAEFMSKEI EVKDIFGKVK IESEKEAKIW KFPIKTLSQS
610 620 630
ESGWDFVQQG VSYTFLYPIE KMLNIKLKFK ESM
Length:633
Mass (Da):75,018
Last modified:August 1, 1998 - v1
Checksum:i9DCBCBB2FE191501
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29262.1
PIRiG71241
RefSeqiWP_010884302.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29262; BAA29262; BAA29262
GeneIDi1444084
KEGGipho:PH0193

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29262.1
PIRiG71241
RefSeqiWP_010884302.1, NC_000961.1

3D structure databases

ProteinModelPortaliO57932
SMRiO57932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0193

Protein family/group databases

CAZyiGH57 Glycoside Hydrolase Family 57

Proteomic databases

PRIDEiO57932

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29262; BAA29262; BAA29262
GeneIDi1444084
KEGGipho:PH0193

Phylogenomic databases

eggNOGiarCOG03280 Archaea
COG1449 LUCA
HOGENOMiHOG000223207
KOiK22451
OMAiHFMSAGL
OrthoDBiPOG093Z00N7

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-183-MONOMER

Family and domain databases

Gene3Di2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR015179 A-amylase/a-glucTrfase_C
IPR015178 A-amylase/a-glucTrfase_central
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR028995 Glyco_hydro_57/38_cen_sf
IPR004300 Glyco_hydro_57_N
PfamiView protein in Pfam
PF09094 DUF1925, 1 hit
PF09095 DUF1926, 1 hit
PF03065 Glyco_hydro_57, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014405 DUF1925, 1 hit
SUPFAMiSSF74650 SSF74650, 1 hit
SSF88688 SSF88688, 1 hit
SSF88713 SSF88713, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMYA_PYRHO
AccessioniPrimary (citable) accession number: O57932
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again