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Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulationi

Activated by citrate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei191Schiff-base intermediate with dihydroxyacetone-PBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-83-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fba
Ordered Locus Names:PH0082
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001389501 – 281Fructose-bisphosphate aldolase class 1Add BLAST281

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi70601.PH0082

Structurei

3D structure databases

ProteinModelPortaliO57840
SMRiO57840
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family.Curated

Phylogenomic databases

eggNOGiarCOG04044 Archaea
COG1830 LUCA
HOGENOMiHOG000224790
KOiK11645
OMAiGMPLMIE
OrthoDBiPOG093Z070T

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002915 DeoC/FbaB/lacD_aldolase
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF038992 Aldolase_Ia, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit

Sequencei

Sequence statusi: Complete.

O57840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALQNLGIR RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPKV
60 70 80 90 100
IIRKVVRAGI DGVMMLPGIA RIAGDEVKPD VGLMIKLTSK TNLRPKPDQL
110 120 130 140 150
LQSQLAYVED AIKLGADAIA ATVYWGSPQE DTMIRQFAEI ASYAHDLGYP
160 170 180 190 200
VVQFAYPRGP YIDEKYGKKE DYRVVMYGAR AAAESGADMI KTYWTGSKET
210 220 230 240 250
FAKVVEAAAG VPVLMSGGAK TDNPLDFLKV VWEVIEAGGS GAVVGRNIFQ
260 270 280
RENPESMIRA LIRVIHRNED PEEAAKAEGL I
Length:281
Mass (Da):31,189
Last modified:August 1, 1998 - v1
Checksum:i9AB0E4501E983068
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29151.1
PIRiH71227
RefSeqiWP_010884202.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29151; BAA29151; BAA29151
GeneIDi1443984
KEGGipho:PH0082

Similar proteinsi

Entry informationi

Entry nameiALF1_PYRHO
AccessioniPrimary (citable) accession number: O57840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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