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Protein

Trk system potassium uptake protein TrkA homolog

Gene

trkA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a potassium transport system.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30NADBy similarity1
Binding sitei51NADBy similarity1
Binding sitei98NAD; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 11NADBy similarity5
Nucleotide bindingi73 – 74NADBy similarity2

GO - Molecular functioni

Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandNAD, Potassium

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1920-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Trk system potassium uptake protein TrkA homolog
Short name:
K(+)-uptake protein TrkA homolog
Gene namesi
Name:trkA
Ordered Locus Names:PH1984
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487281 – 228Trk system potassium uptake protein TrkA homologAdd BLAST228

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1984

Structurei

3D structure databases

ProteinModelPortaliO57719
SMRiO57719
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 130RCK N-terminalPROSITE-ProRule annotationAdd BLAST129
Domaini141 – 223RCK C-terminalPROSITE-ProRule annotationAdd BLAST83

Domaini

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).By similarity

Phylogenomic databases

eggNOGiarCOG01957 Archaea
COG0569 LUCA
HOGENOMiHOG000243320
KOiK03499
OMAiNAIEYPQ
OrthoDBiPOG093Z01XT

Family and domain databases

Gene3Di3.30.70.1450, 1 hit
InterProiView protein in InterPro
IPR006036 K_uptake_TrkA
IPR036291 NAD(P)-bd_dom_sf
IPR006037 RCK_C
IPR036721 RCK_C_sf
IPR003148 RCK_N
PfamiView protein in Pfam
PF02080 TrkA_C, 1 hit
PF02254 TrkA_N, 1 hit
PRINTSiPR00335 KUPTAKETRKA
SUPFAMiSSF116726 SSF116726, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51202 RCK_C, 1 hit
PS51201 RCK_N, 1 hit

Sequencei

Sequence statusi: Complete.

O57719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYIVIMGAGR IGTLVARMLE SEGHDVAIIE MNRERAREIS EYISGLVIEG
60 70 80 90 100
DATDQKVLEN ANIKNANAFA ALTGKDDANI LACILAKHLN PNIMTILRIT
110 120 130 140 150
DPGKKKIFED VKELKTYFDI VVSPEDIAAN YIFRTLVTPG FNRVLLPREG
160 170 180 190 200
AEIIQFQIDE DCEVAGKPVK ELNLPKDSLI IAVYDEKGNL TIPSGDTIIP
210 220
KKGQVIIFAK NSALQEVKKI MEKKKKEQ
Length:228
Mass (Da):25,323
Last modified:August 1, 1998 - v1
Checksum:iF64E2D14EFE3FFD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA31111.1
PIRiH71214
RefSeqiWP_010886046.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA31111; BAA31111; BAA31111
GeneIDi1442828
KEGGipho:PH1984

Similar proteinsi

Entry informationi

Entry nameiTRKA_PYRHO
AccessioniPrimary (citable) accession number: O57719
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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