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Entry version 106 (12 Aug 2020)
Sequence version 2 (29 May 2007)
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Protein

Paired box protein Pax-2-A

Gene

pax2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 in pronephric morphogenesis during the tailbud stages (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi16 – 142PairedPROSITE-ProRule annotationAdd BLAST127

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Segmentation polarity protein
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired box protein Pax-2-A
Short name:
xPax-2a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pax2-a
Synonyms:pax-2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-486805, pax2.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891321 – 497Paired box protein Pax-2-AAdd BLAST497

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression becomes spatially localized at mid-gastrula stages and is confined to the nervous system (midbrain, hindbrain, spinal cord), sensory organs (optic vesicle and stalk, otic vesicle), visceral arches, developing excretory system (pronephros, pronephric duct, rectal diverticulum, proctodaeum) and thyroid gland. Splicing does not appear to be tissue-specific and tissues displayed the same spectrum of splice variants.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Splicing is temporally regulated. Isoform 5 is expressed both maternally and zygotically, whereas isoform 1, isoform 2, isoform 3 and isoform 4 are exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By activin. Weakly by bFGF.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O57685

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 75PAI subdomainPROSITE-ProRule annotationAdd BLAST57
Regioni94 – 142RED subdomainPROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Paired box

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K15608

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPVHIRG

Database of Orthologous Groups

More...
OrthoDBi
592933at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00131, PAX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR043182, PAIRED_DNA_bd_dom
IPR001523, Paired_dom
IPR022130, Pax2_C
IPR043565, PAX_fam
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45636, PTHR45636, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00292, PAX, 1 hit
PF12403, Pax2_C, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00027, PAIREDBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00351, PAX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00034, PAIRED_1, 1 hit
PS51057, PAIRED_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O57685-1) [UniParc]FASTAAdd to basket
Also known as: 41 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR
60 70 80 90 100
PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA
110 120 130 140 150
EYKRQNPTMF AWEIRDRLLA EGICDNDTVP SVSSINRIIR TKVQQPFHPT
160 170 180 190 200
PDGSGTPVGT PGHTLVPSTA SPPVSSASND PVGSYSINGI LGIPRSNGEK
210 220 230 240 250
RKRDEDGSDG SGPNGDSQSS VESLRKHLRA DNFTQQQLEA LDRVFERPSY
260 270 280 290 300
PDVFQTAEHI KSEQASEYSL PALTPGLDEV KSSLSASGNA DLGSNVSGPQ
310 320 330 340 350
SYPVVTESFA SHLYVKQEPH EASLTPFTPS SLASSGLADI QPFQMALTVD
360 370 380 390 400
ASTPTYSSFT HHGPHYGQFG SQPLIAGRDM SSTTLPGYPP HVPPTGQGSY
410 420 430 440 450
PTSTLAGMVP GTNVSVHHSV QPVECCSCLS SSKPCLFHCR TGSGSEFSGN
460 470 480 490
PYSHPQYTTY NEAWRFSNPA LLSSPYYYSA TSRGSAPPTA ATAYDRH
Length:497
Mass (Da):53,204
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2815A8C329878237
GO
Isoform 2 (identifier: O57685-2) [UniParc]FASTAAdd to basket
Also known as: 11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     307-376: Missing.
     412-444: Missing.

Show »
Length:394
Mass (Da):42,229
Checksum:iBC81726C6E51EDF2
GO
Isoform 31 Publication (identifier: O57685-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-376: Missing.

Show »
Length:427
Mass (Da):45,702
Checksum:i7E6EF01E04E062C1
GO
Isoform 4 (identifier: O57685-4) [UniParc]FASTAAdd to basket
Also known as: 51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     166-205: Missing.
     307-376: Missing.
     412-444: Missing.

Show »
Length:354
Mass (Da):38,106
Checksum:i059AC72416A555F7
GO
Isoform 5 (identifier: O57685-5) [UniParc]FASTAAdd to basket
Also known as: 71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     206-376: Missing.
     445-445: S → FLGS

Show »
Length:329
Mass (Da):35,283
Checksum:i81DE1C10F3CED0A4
GO
Isoform 6 (identifier: O57685-6) [UniParc]FASTAAdd to basket
Also known as: 10

The sequence of this isoform differs from the canonical sequence as follows:
     166-376: Missing.
     412-444: Missing.
     445-445: S → FLGS

Show »
Length:256
Mass (Da):27,687
Checksum:i4B225AC9EAA7BF6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91A → T in CAA71208 (PubMed:9486533).Curated1
Sequence conflicti144Q → R in CAA71208 (PubMed:9486533).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052436166 – 376Missing in isoform 6. 1 PublicationAdd BLAST211
Alternative sequenceiVSP_052435166 – 205Missing in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_052437206 – 376Missing in isoform 5. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_052438307 – 376Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_052439412 – 444Missing in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_052440445S → FLGS in isoform 5 and isoform 6. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y10119 mRNA Translation: CAA71205.1
Y10121 mRNA Translation: CAA71207.1
Y10122 mRNA Translation: CAA71208.1
Y10123 mRNA Translation: CAA71209.1
AJ000667 mRNA Translation: CAA04223.1
BC055960 mRNA Translation: AAH55960.1

NCBI Reference Sequences

More...
RefSeqi
NP_001079830.1, NM_001086361.1 [O57685-3]
XP_018079766.1, XM_018224277.1 [O57685-1]
XP_018079772.1, XM_018224283.1 [O57685-2]
XP_018079775.1, XM_018224286.1 [O57685-4]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
379520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:379520

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10119 mRNA Translation: CAA71205.1
Y10121 mRNA Translation: CAA71207.1
Y10122 mRNA Translation: CAA71208.1
Y10123 mRNA Translation: CAA71209.1
AJ000667 mRNA Translation: CAA04223.1
BC055960 mRNA Translation: AAH55960.1
RefSeqiNP_001079830.1, NM_001086361.1 [O57685-3]
XP_018079766.1, XM_018224277.1 [O57685-1]
XP_018079772.1, XM_018224283.1 [O57685-2]
XP_018079775.1, XM_018224286.1 [O57685-4]

3D structure databases

SMRiO57685
ModBaseiSearch...

Genome annotation databases

GeneIDi379520
KEGGixla:379520

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
379520
XenbaseiXB-GENE-486805, pax2.L

Phylogenomic databases

KOiK15608
OMAiDPVHIRG
OrthoDBi592933at2759

Family and domain databases

CDDicd00131, PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR043182, PAIRED_DNA_bd_dom
IPR001523, Paired_dom
IPR022130, Pax2_C
IPR043565, PAX_fam
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR45636, PTHR45636, 1 hit
PfamiView protein in Pfam
PF00292, PAX, 1 hit
PF12403, Pax2_C, 2 hits
PRINTSiPR00027, PAIREDBOX
SMARTiView protein in SMART
SM00351, PAX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034, PAIRED_1, 1 hit
PS51057, PAIRED_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAX2A_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O57685
Secondary accession number(s): O57677
, O57680, O57681, O57684, Q7SZU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: August 12, 2020
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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