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Entry version 110 (17 Jun 2020)
Sequence version 2 (15 Mar 2017)
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Protein

Aminopeptidase Ey

Gene

ANPEP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Broad specificity aminopeptidase. Degrades a variety of peptides possessing various N-terminal amino acids including hydrophobic, basic and acidic amino acids. Preferentially hydrolyzes small peptides consisting of 4 or 5 amino acids. Hydrolyzes the N-terminal Xaa-Pro bonds in the chicken brain peptide Leu-Pro-Leu-Arg-PheNH2, the substance P fragment Arg-Pro-Lys-Pro and the bradykinin fragment Arg-Pro-Pro-Gly-Phe. Hydrolyzes the N-formylated peptides fMet-Leu-Phe, fMet-Ala-Gly-Ser-Glu and fMet-Nle-Leu-Phe-Nle-Tyr-Lys, but does not hydrolyze peptides with acetylation or pyroglutamic acid at N-terminus. Does not hydrolyze large peptides such as complete substance P, bradykinin or schistoFLRFamide.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.58 mM for Leu-Pro-Leu-Arg-PheNH22 Publications
  2. KM=1.23 mM for fMet-Leu-Phe2 Publications
  3. KM=1.53 mM for fMet-Ala-Gly-Ser-Glu2 Publications
  4. KM=1.72 mM for fMet-Nle-Leu-Phe-Nle-Tyr-Lys2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi391Zinc; catalyticPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei392Proton acceptorPROSITE-ProRule annotation1
    Metal bindingi395Zinc; catalyticPROSITE-ProRule annotation1
    Metal bindingi414Zinc; catalyticPROSITE-ProRule annotation1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei480Transition state stabilizerBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    O57579

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M01.016

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aminopeptidase Ey1 Publication (EC:3.4.11.202 Publications)
    Alternative name(s):
    Aminopeptidase NImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ANPEP
    Synonyms:APDE
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 10CytoplasmicSequence analysis9
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini32 – 972ExtracellularAdd BLAST941

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003947492 – 972Aminopeptidase EyAdd BLAST971

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi684N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi742N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi764 ↔ 771By similarity
    Glycosylationi785N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi801 ↔ 837By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O57579

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O57579

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in the plasma and granule fractions of egg yolk (at protein level).1 Publication

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9031.ENSGALP00000040682

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O57579

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 72Cytosolic Ser/Thr-rich junctionBy similarityAdd BLAST40
    Regioni73 – 967MetalloproteaseBy similarityAdd BLAST895
    Regioni355 – 359Substrate bindingBy similarity5

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M1 family.Sequence analysis

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000154876

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O57579

    KEGG Orthology (KO)

    More...
    KOi
    K11140

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    TAKWFIF

    Database of Orthologous Groups

    More...
    OrthoDBi
    110058at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O57579

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd09601 M1_APN-Q_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.1730, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR042097 Aminopeptidase_N-like_N
    IPR024571 ERAP1-like_C_dom
    IPR034016 M1_APN-typ
    IPR001930 Peptidase_M1
    IPR014782 Peptidase_M1_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF11838 ERAP1_C, 1 hit
    PF01433 Peptidase_M1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00756 ALADIPTASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF63737 SSF63737, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    O57579-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAGFFISKS VGIVGIVLAL GAVATIIALS VVYAQEKNKS SGGSGGSDTT
    60 70 80 90 100
    STTTASTTTT STTTASTTAA PNNPWNRWRL PTALKPESYE VTLQPFLTPD
    110 120 130 140 150
    DNNMYIFKGN SSVVFLCEEA TDLILIHSNK LNYTLQGGFH ASLHAVNGST
    160 170 180 190 200
    PPTISNTWLE TNTQYLVLQL AGPLQQGQHY RLFSIFTGEL ADDLAGFYRS
    210 220 230 240 250
    EYTEGNVTKV VATTQMQAPD ARKAFPCFDE PAMKAVFTVT MIHPSDHTAI
    260 270 280 290 300
    SNMPVHSTYQ LQMDGQSWNV TQFDPTPRMS TYLLAFIVSQ FDYVENNTGK
    310 320 330 340 350
    VQIRIWGRPA AIAEGQGEYA LEKTGPILSF FERHYNTAYP LPKSDQVGLP
    360 370 380 390 400
    DFNAGAMENW GLVTYRENSL LYDNAYSSIG NKERVVTVIA HELAHQWFGN
    410 420 430 440 450
    LVTLRWWNDL WLNEGFASYV EYLGADSAEP TWDIKDLMVL NELYTVMATD
    460 470 480 490 500
    ALTTSHPLTF REDEINTPAQ ISEVFDSIAY SKGASVLRML SDFLTEDVFK
    510 520 530 540 550
    EGLQSYLHDF SYNNTVYTDL WDHLQEAVNK NSVPLPDSIG AIMDRWTLQM
    560 570 580 590 600
    GFPVVTVNTL TGSVQQSHFL LDSNSTVERP SVFNYTWIVP ITWMTPSRTG
    610 620 630 640 650
    DRYWLVDVSA TNSDFSVGSS TWLLLNLNVS GYFRVNYNQE NWDQLLQQLS
    660 670 680 690 700
    NNHQAIPVIN RAQIIDDAFN LARAQQVSVT LALNTTRFLS GETAYMPWQA
    710 720 730 740 750
    ALNNLQYFQL MFDRSEVFGA MTKYIQKQVT PLFEYYRTAT NNWTAIPSAL
    760 770 780 790 800
    MDQYNEINAI STACSYGIAE CQQLATALYQ QWRQNVSNNP IAPNLRSAIY
    810 820 830 840 850
    CSAVATGGEE VWDFIWERFL EAPVVSEADK LRTALTCSTE TWILQRYLQY
    860 870 880 890 900
    TIDPTKIRKQ DATSTINSIA SNVVGQPLAW DFIRSNWRTL FGQYGGGSFS
    910 920 930 940 950
    FSRLISAVTQ RFNTEFELKQ LEQFKADNQD IGFGSGTRAL EQALERTRTN
    960 970
    INWVKENKEV VHAWFRAETA SS
    Length:972
    Mass (Da):109,132
    Last modified:March 15, 2017 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i701F1BC0BCE1F852
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti56 – 60Missing in BAA24263 (PubMed:9734335).Curated5
    Sequence conflicti56 – 60Missing in ACZ95799 (Ref. 2) Curated5
    Sequence conflicti248T → K in ACZ95799 (Ref. 2) Curated1
    Sequence conflicti255V → A in ACZ95799 (Ref. 2) Curated1
    Sequence conflicti538S → T in ACZ95799 (Ref. 2) Curated1
    Sequence conflicti614D → N in BAA24263 (PubMed:9734335).Curated1
    Sequence conflicti614D → N in ACZ95799 (Ref. 2) Curated1
    Sequence conflicti675 – 678QQVS → HNVN in BAA24263 (PubMed:9734335).Curated4
    Sequence conflicti923Q → H in BAA24263 (PubMed:9734335).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D87992 mRNA Translation: BAA24263.1
    GU223212 mRNA Translation: ACZ95799.1
    AADN04000131 Genomic DNA No translation available.

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_990192.1, NM_204861.1
    XP_015147557.1, XM_015292071.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSGALT00000064511; ENSGALP00000044885; ENSGALG00000027501

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    395667

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    gga:395667

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D87992 mRNA Translation: BAA24263.1
    GU223212 mRNA Translation: ACZ95799.1
    AADN04000131 Genomic DNA No translation available.
    RefSeqiNP_990192.1, NM_204861.1
    XP_015147557.1, XM_015292071.1

    3D structure databases

    SMRiO57579
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000040682

    Protein family/group databases

    MEROPSiM01.016

    Proteomic databases

    PaxDbiO57579
    PRIDEiO57579

    Genome annotation databases

    EnsembliENSGALT00000064511; ENSGALP00000044885; ENSGALG00000027501
    GeneIDi395667
    KEGGigga:395667

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    290

    Phylogenomic databases

    GeneTreeiENSGT00940000154876
    InParanoidiO57579
    KOiK11140
    OMAiTAKWFIF
    OrthoDBi110058at2759
    PhylomeDBiO57579

    Enzyme and pathway databases

    SABIO-RKiO57579

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:O57579

    Family and domain databases

    CDDicd09601 M1_APN-Q_like, 1 hit
    Gene3Di2.60.40.1730, 1 hit
    InterProiView protein in InterPro
    IPR042097 Aminopeptidase_N-like_N
    IPR024571 ERAP1-like_C_dom
    IPR034016 M1_APN-typ
    IPR001930 Peptidase_M1
    IPR014782 Peptidase_M1_dom
    PfamiView protein in Pfam
    PF11838 ERAP1_C, 1 hit
    PF01433 Peptidase_M1, 1 hit
    PRINTSiPR00756 ALADIPTASE
    SUPFAMiSSF63737 SSF63737, 1 hit
    PROSITEiView protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPN_CHICK
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O57579
    Secondary accession number(s): A0A1D5NWZ2, D2KKL5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: March 15, 2017
    Last modified: June 17, 2020
    This is version 110 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Peptidase families
      Classification of peptidase families and list of entries
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