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UniProtKB - O57422 (OPN4B_XENLA)
Protein
Melanopsin-B
Gene
opn4b
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Photoreceptor implicated in non-image-forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).
By similarityGO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- photoreceptor activity Source: UniProtKB-KW
GO - Biological processi
- phototransduction Source: UniProtKB-KW
- protein-chromophore linkage Source: UniProtKB-KW
- visual perception Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer |
Biological process | |
Ligand | Chromophore |
Protein family/group databases
TCDBi | 9.A.14.1.7, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Melanopsin-BAlternative name(s): Opsin-4B Short name: xMOP |
Gene namesi | Name:opn4bBy similarity Synonyms:mopImported |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-5957217, XB5957215.L |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 53 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 54 – 64 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 65 – 85 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 102 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 103 – 123 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 146 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 147 – 167 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 168 – 198 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 199 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 250 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 251 – 271 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 272 – 286 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 287 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 534 | CytoplasmicSequence analysisAdd BLAST | 227 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271892 | 1 – 534 | Melanopsin-BAdd BLAST | 534 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 100 ↔ 178 | PROSITE-ProRule annotation | ||
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 294 | N6-(retinylidene)lysineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinExpressioni
Tissue specificityi
Highest level in the iris, high level in the inner nuclear layer, possibly in horizontal cells, and lowest level in retinal pigment epithelium. Expressed in melanophore cells of the skin.1 Publication
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 478 – 501 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 480 – 501 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OMAi | ELPIICA |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001760, Opsin IPR027430, Retinal_BS |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00238, OPSIN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS00238, OPSIN, 1 hit |
i Sequence
Sequence statusi: Complete.
O57422-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLGKTVEYG THRQDAIAQI DVPDQVLYTI GSFILIIGSV GIIGNMLVLY
60 70 80 90 100
AFYRNKKLRT APNYFIINLA ISDFLMSATQ APVCFLSSLH REWILGDIGC
110 120 130 140 150
NVYAFCGALF GITSMMTLLA ISINRYIVIT KPLQSIQWSS KKRTSQIIVL
160 170 180 190 200
VWMYSLMWSL APLLGWSSYV PEGLRISCTW DYVTSTMSNR SYTMMLCCCV
210 220 230 240 250
FFIPLIVISH CYLFMFLAIR STGRNVQKLG SYGRQSFLSQ SMKNEWKMAK
260 270 280 290 300
IAFVIIIVFV LSWSPYACVT LIAWAGHGKS LTPYSKTVPA VIAKASAIYN
310 320 330 340 350
PIIYGIIHPK YRETIHKTVP CLRFLIREPK KDIFESSVRG SIYGRQSASR
360 370 380 390 400
KKNSFISTVS TAETVSSHIW DNTPNGHWDR KSLSQTMSNL CSPLLQDPNS
410 420 430 440 450
SHTLEQTLTW PDDPSPKEIL LPSSLKSVTY PIGLESIVKD EHTNNSCVRN
460 470 480 490 500
HRVDKSGGLD WIINATLPRI VIIPTSESNI SETKEEHDNN SEEKSKRTEE
510 520 530
EEDFFNFHVD TSLLNLEGLN SSTDLYEVVE RFLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF014797 mRNA Translation: AAC41235.1 |
RefSeqi | NP_001079143.1, NM_001085674.1 XP_018110053.1, XM_018254564.1 |
Genome annotation databases
GeneIDi | 373689 |
KEGGi | xla:373689 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF014797 mRNA Translation: AAC41235.1 |
RefSeqi | NP_001079143.1, NM_001085674.1 XP_018110053.1, XM_018254564.1 |
3D structure databases
SMRi | O57422 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 9.A.14.1.7, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
Genome annotation databases
GeneIDi | 373689 |
KEGGi | xla:373689 |
Organism-specific databases
CTDi | 373689 |
Xenbasei | XB-GENE-5957217, XB5957215.L |
Phylogenomic databases
OMAi | ELPIICA |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001760, Opsin IPR027430, Retinal_BS |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00238, OPSIN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS00238, OPSIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OPN4B_XENLA | |
Accessioni | O57422Primary (citable) accession number: O57422 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | June 1, 1998 | |
Last modified: | September 29, 2021 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families