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Protein

Phosphoprotein

Gene

P

Organism
Duvenhage virus (DUVV)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion, Viral RNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoprotein
Short name:
Protein P
Alternative name(s):
Protein M1
Gene namesi
Name:P
OrganismiDuvenhage virus (DUVV)
Taxonomic identifieri38767 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]

Subcellular locationi

Isoform P4 :

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990941 – 298PhosphoproteinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Phosphoserine; by hostBy similarity1
Modified residuei211Phosphoserine; by host PKCBy similarity1
Modified residuei272Phosphoserine; by host PKCBy similarity1

Post-translational modificationi

Phosphorylated by host PKC and by an unknown kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO56774

Interactioni

Subunit structurei

Homotrimer when phosphorylated. This trimer is stabilized by binding to the L protein. Binds soluble protein N, and ribonucleocapsid. Interacts with host STAT1, STAT2, DYNLL1, DYNLL2 and PML. Isoform P3 binds host PML (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO56774
SMRiO56774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 58Nuclear export signalBy similarity10
Motifi212 – 215Nuclear localization signalBy similarity4

Sequence similaritiesi

Belongs to the lyssavirus protein P family.Curated

Family and domain databases

Gene3Di1.20.120.820, 1 hit
InterProiView protein in InterPro
IPR004259 PP_M1
IPR037199 PP_M1_C
PfamiView protein in Pfam
PF03012 PP_M1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004155 PP_M1, 1 hit
SUPFAMiSSF118173 SSF118173, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative initiation. AlignAdd to basket
Isoform P (identifier: O56774-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKIFINPSD IRSGLADLEM AEETVELVNR NMEDSQAHLQ GVPIDVETLP
60 70 80 90 100
EDIQRLHITD PQASLRQDMV DEQKHQEDED FYLTGRENPL SPFQTHLDAI
110 120 130 140 150
GLRIVRKMKT GEGFFKIWSQ AVEDIVSYVA LNFSIPVNKL FEDKSTQTVT
160 170 180 190 200
EKSQQASASS APNRHEKSSQ NARVNSKDAS GPAALDWTAS NEADDESVEA
210 220 230 240 250
EIAHQIAESF SKKYKFPSRS SGIFLWNFEQ LKMNLDEIVR EVKEIPGVIK
260 270 280 290
MAKDGMKLPL RCMLGGVAST HSRRFQILVN PEKLGKVMQE DLDKYLTY
Length:298
Mass (Da):33,674
Last modified:June 1, 1998 - v1
Checksum:iC057726AC335803C
GO
Isoform P2 (identifier: O56774-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:279
Mass (Da):31,586
Checksum:i3A05BDEDEEC8955F
GO
Isoform P4 (identifier: O56774-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:230
Mass (Da):26,020
Checksum:i6878CDB03A50D75B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0275541 – 68Missing in isoform P4. CuratedAdd BLAST68
Alternative sequenceiVSP_0275551 – 19Missing in isoform P2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049115 mRNA Translation: AAC04585.1
RefSeqiYP_007641403.1, NC_020810.1 [O56774-1]

Genome annotation databases

GeneIDi14857938
KEGGivg:14857938

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiPHOSP_DUVV
AccessioniPrimary (citable) accession number: O56774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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