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Protein

Protein C'

Gene

P/V/C

Organism
Sendai virus (strain Ohita) (SeV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The different products prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. They inhibit IFN-alpha/beta induced tyrosine phosphorylation of STAT1 and STAT2. Blocking the IFN-alpha/beta pathway requires binding to STAT1 in the cytoplasm. They inhibit IFN-gamma induced serine phosphorylation of STAT1. Block the IFN-gamma pathway by binding to and stabilizing the parallel form of the STAT1 dimer, further inducing high-molecular-weight complex formation and inhibition of transcription by IFN-gamma. May also have a role in preventing the cell to enter apoptosis. Modulate regulation of viral transcription and replication. Overexpression inhibits the viral RNA polymerase. The absence of all C', C and Y1 proteins leads to viral delayed growth. Plays an important role in virion particles release. Modulates virion shape.By similarity

Miscellaneous

The C protein is found in virion at a ratio of approximately 40 molecules per virion, presumably associated with the nucleocapsid.By similarity
The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C/Y proteins.Curated

Caution

The C' protein uses an unusual ACG start codon.Curated

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C'
Gene namesi
Name:P/V/C
OrganismiSendai virus (strain Ohita) (SeV)
Taxonomic identifieri302272 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeRespirovirus
Virus hostiCavia cutleri (Guinea pig) [TaxID: 10144]
Cricetidae sp. (Hamster) [TaxID: 36483]
Mus musculus (Mouse) [TaxID: 10090]
Rattus norvegicus (Rat) [TaxID: 10116]
Proteomesi
  • UP000006563 Componenti: Genome
  • UP000007311 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by hostBy similarity
ChainiPRO_00000394082 – 215Protein C'Add BLAST214

Post-translational modificationi

Protein Y1 is produced not only by alternative initiation, but also by proteolytic cleavage of C'. Only alternative initiation is detected in vitro, whereas in vivo cleavage seems to be predominant.By similarity

Interactioni

Subunit structurei

The different isoforms interact (via C-terminus) with unphosphorylated and phosphorylated human STAT1 (via N-terminus), favoring the formation of parallel STAT1 homodimers. The different isoforms do not interact with host STAT2. C protein interacts with L protein; this interaction has an inhibitory effect on viral transcription and replication.By similarity

Structurei

3D structure databases

SMRiO55527
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 34DisorderedBy similarityAdd BLAST23
Regioni15 – 22Involved in self-degradation and in host STAT1 degradationBy similarity8

Domaini

The disordered region at the N-terminus is involved in C protein self-degradation in trans. This self-degradation of C protein may play a role in the regulation of viral RNA synthesis. The disordered region at the N-terminus is also involved in the host STAT1 degradation in order to counteract the host innate antiviral response.By similarity

Sequence similaritiesi

Belongs to the respirovirus protein C family.Curated

Phylogenomic databases

OrthoDBiVOG090000QC

Family and domain databases

InterProiView protein in InterPro
IPR002608 Paramyxo_C
PfamiView protein in Pfam
PF01692 Paramyxo_C, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative initiation. AlignAdd to basket
Isoform C' (identifier: O55527-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASATLPAWI KMPSFLKKIL KLRGRRQEDE SRSRMLSDSS TQSYQVNQLT
60 70 80 90 100
SEGTEAGSTI PSTPSKGQAL PTESKVRARE KSRHRRPKII DQVRRVESLG
110 120 130 140 150
EQASQRQKHM LETLINKIYT GPLGEELVQT LYLRIWAMEE TPESLKILQM
160 170 180 190 200
REDIRDQVLK MKTERWLRTL IRGEKTKLKD FQKRYEEVHP YLMKEKVEQI
210
IMEEAWSLAA HIVQE
Note: The initiator methionine is coded by an unusual start codon ACG.
Length:215
Mass (Da):25,162
Last modified:January 23, 2007 - v3
Checksum:iA94696F9D9875685
GO
Isoform C (identifier: O55527-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Note: Most abundant isoform in infected cells.
Show »
Length:204
Mass (Da):23,992
Checksum:i950DD3DA387229C9
GO
Isoform Y1 (identifier: O55527-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:181
Mass (Da):21,178
Checksum:iA250A361AF313179
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti181F → S in strain: Isolate MVC11; avirulent mutant. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0189431 – 34Missing in isoform Y1. CuratedAdd BLAST34
Alternative sequenceiVSP_0189421 – 11Missing in isoform C. CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005795 Genomic RNA Translation: BAA24385.1
AB005795 Genomic RNA Translation: BAA24387.1
AB005795 Genomic RNA Translation: BAA24388.1
AB005796 Genomic RNA Translation: BAA24394.1
AB005796 Genomic RNA Translation: BAA24396.1
AB005796 Genomic RNA Translation: BAA24397.1
RefSeqiNP_056872.1, NC_001552.1
NP_056874.1, NC_001552.1
NP_056875.1, NC_001552.1

Genome annotation databases

GeneIDi1489773
1489774
1489781
KEGGivg:1489773
vg:1489774
vg:1489781

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005795 Genomic RNA Translation: BAA24385.1
AB005795 Genomic RNA Translation: BAA24387.1
AB005795 Genomic RNA Translation: BAA24388.1
AB005796 Genomic RNA Translation: BAA24394.1
AB005796 Genomic RNA Translation: BAA24396.1
AB005796 Genomic RNA Translation: BAA24397.1
RefSeqiNP_056872.1, NC_001552.1
NP_056874.1, NC_001552.1
NP_056875.1, NC_001552.1

3D structure databases

SMRiO55527
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489773
1489774
1489781
KEGGivg:1489773
vg:1489774
vg:1489781

Phylogenomic databases

OrthoDBiVOG090000QC

Family and domain databases

InterProiView protein in InterPro
IPR002608 Paramyxo_C
PfamiView protein in Pfam
PF01692 Paramyxo_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC_SENDO
AccessioniPrimary (citable) accession number: O55527
Secondary accession number(s): O55529
, O92615, Q9WME0, Q9WME1, Q9WME2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 58 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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