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Protein

Orexin

Gene

Hcrt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin
Alternative name(s):
Hypocretin
Short name:
Hcrt
Cleaved into the following 2 chains:
Alternative name(s):
Hypocretin-1
Short name:
Hcrt1
Alternative name(s):
Hypocretin-2
Short name:
Hcrt2
Gene namesi
Name:Hcrt
Synonyms:Ox, Ppox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1202306 Hcrt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
PeptideiPRO_000002026433 – 65Orexin-AAdd BLAST33
PeptideiPRO_000002026569 – 96Orexin-BAdd BLAST28
PropeptideiPRO_000002026697 – 130Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi38 ↔ 44By similarity
Disulfide bondi39 ↔ 46By similarity
Modified residuei65Leucine amideBy similarity1
Modified residuei96Methionine amideBy similarity1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiO55241
PRIDEiO55241

Expressioni

Tissue specificityi

Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus.

Gene expression databases

BgeeiENSMUSG00000045471
CleanExiMM_HCRT
MM_PPOX
ExpressionAtlasiO55241 baseline and differential
GenevisibleiO55241 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057578

Structurei

3D structure databases

ProteinModelPortaliO55241
SMRiO55241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4FI Eukaryota
ENOG410Y5WS LUCA
GeneTreeiENSGT00390000014272
HOGENOMiHOG000230990
HOVERGENiHBG000256
InParanoidiO55241
KOiK05246
OMAiSECCRQP
OrthoDBiEOG091G0K5S
PhylomeDBiO55241
TreeFamiTF330756

Family and domain databases

InterProiView protein in InterPro
IPR001704 Orexin
PANTHERiPTHR15173 PTHR15173, 1 hit
PfamiView protein in Pfam
PF02072 Orexin, 1 hit
PIRSFiPIRSF037824 Orexin, 1 hit
PRINTSiPR01091 OREXINPP

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFPSTKVPW AAVTLLLLLL LPPALLSLGV DAQPLPDCCR QKTCSCRLYE
60 70 80 90 100
LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQANGNHA AGILTMGRRA
110 120 130
GAELEPHPCS GRGCPTVTTT ALAPRGGSGV
Length:130
Mass (Da):13,503
Last modified:June 1, 1998 - v1
Checksum:iD3C223F9EE835F1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041242 mRNA Translation: AAC40040.1
AF019566 mRNA Translation: AAC02934.1
CCDSiCCDS25436.1
RefSeqiNP_034540.1, NM_010410.2
UniGeneiMm.10096

Genome annotation databases

EnsembliENSMUST00000055083; ENSMUSP00000057578; ENSMUSG00000045471
GeneIDi15171
KEGGimmu:15171
UCSCiuc007lmg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiOREX_MOUSE
AccessioniPrimary (citable) accession number: O55241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

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