UniProtKB - O55237 (CD70_MOUSE)
Protein
CD70 antigen
Gene
Cd70
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.1 Publication
GO - Molecular functioni
- cytokine activity Source: UniProtKB
- protease binding Source: MGI
- tumor necrosis factor receptor binding Source: InterPro
GO - Biological processi
- B cell mediated immunity Source: UniProtKB
- B cell proliferation Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: MGI
- T cell mediated immunity Source: UniProtKB
- tumor necrosis factor-mediated signaling pathway Source: InterPro
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
Reactomei | R-MMU-5669034, TNFs bind their physiological receptors |
Names & Taxonomyi
Protein namesi | Recommended name: CD70 antigenAlternative name(s): CD27 ligand Short name: CD27-L Tumor necrosis factor ligand superfamily member 7 CD_antigen: CD70 |
Gene namesi | Name:Cd70 Synonyms:Cd27l, Cd27lg, Tnfsf7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1195273, Cd70 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type II membrane protein Sequence analysis
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 44 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 195 | ExtracellularSequence analysisAdd BLAST | 151 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185498 | 1 – 195 | CD70 antigenAdd BLAST | 195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 135 ↔ 153 | Sequence analysis | ||
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O55237 |
PRIDEi | O55237 |
PTM databases
GlyGeni | O55237, 3 sites |
PhosphoSitePlusi | O55237 |
Expressioni
Tissue specificityi
Very low level of expression. Detected in splenocytes and thymocytes.
Inductioni
By IL-2 and concanavalin A (Con A).
Gene expression databases
Bgeei | ENSMUSG00000019489, Expressed in cerebellum and 32 other tissues |
ExpressionAtlasi | O55237, baseline and differential |
Genevisiblei | O55237, MM |
Interactioni
Subunit structurei
Homotrimer.
CuratedGO - Molecular functioni
- cytokine activity Source: UniProtKB
- protease binding Source: MGI
- tumor necrosis factor receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019633 |
Miscellaneous databases
RNActi | O55237, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tumor necrosis factor family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TEKD, Eukaryota |
GeneTreei | ENSGT00390000006744 |
HOGENOMi | CLU_114585_0_0_1 |
InParanoidi | O55237 |
OMAi | FGVQWVH |
OrthoDBi | 1236901at2759 |
PhylomeDBi | O55237 |
TreeFami | TF338269 |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR042374, CD70 IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR15152, PTHR15152, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50049, TNF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O55237-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEEGRPCPW VRWSGTAFQR QWPWLLLVVF ITVFCCWFHC SGLLSKQQQR
60 70 80 90 100
LLEHPEPHTA ELQLNLTVPR KDPTLRWGAG PALGRSFTHG PELEEGHLRI
110 120 130 140 150
HQDGLYRLHI QVTLANCSSP GSTLQHRATL AVGICSPAAH GISLLRGRFG
160 170 180 190
QDCTVALQRL TYLVHGDVLC TNLTLPLLPS RNADETFFGV QWICP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13637, Y13638 Genomic DNA Translation: CAA73977.1 Y13636 mRNA Translation: CAA73976.1 U78091 mRNA Translation: AAD00274.1 |
CCDSi | CCDS28927.1 |
RefSeqi | NP_035747.1, NM_011617.2 |
Genome annotation databases
Ensembli | ENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489 |
GeneIDi | 21948 |
KEGGi | mmu:21948 |
UCSCi | uc008dee.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13637, Y13638 Genomic DNA Translation: CAA73977.1 Y13636 mRNA Translation: CAA73976.1 U78091 mRNA Translation: AAD00274.1 |
CCDSi | CCDS28927.1 |
RefSeqi | NP_035747.1, NM_011617.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019633 |
PTM databases
GlyGeni | O55237, 3 sites |
PhosphoSitePlusi | O55237 |
Proteomic databases
PaxDbi | O55237 |
PRIDEi | O55237 |
Protocols and materials databases
Antibodypediai | 24212, 843 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489 |
GeneIDi | 21948 |
KEGGi | mmu:21948 |
UCSCi | uc008dee.1, mouse |
Organism-specific databases
CTDi | 970 |
MGIi | MGI:1195273, Cd70 |
Phylogenomic databases
eggNOGi | ENOG502TEKD, Eukaryota |
GeneTreei | ENSGT00390000006744 |
HOGENOMi | CLU_114585_0_0_1 |
InParanoidi | O55237 |
OMAi | FGVQWVH |
OrthoDBi | 1236901at2759 |
PhylomeDBi | O55237 |
TreeFami | TF338269 |
Enzyme and pathway databases
Reactomei | R-MMU-5669034, TNFs bind their physiological receptors |
Miscellaneous databases
BioGRID-ORCSi | 21948, 1 hit in 19 CRISPR screens |
PROi | PR:O55237 |
RNActi | O55237, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019489, Expressed in cerebellum and 32 other tissues |
ExpressionAtlasi | O55237, baseline and differential |
Genevisiblei | O55237, MM |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR042374, CD70 IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR15152, PTHR15152, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50049, TNF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD70_MOUSE | |
Accessioni | O55237Primary (citable) accession number: O55237 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families