Cd70

Functionⁱ

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.1 Publication

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
protease binding Source: MGI
tumor necrosis factor receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

extrinsic apoptotic signaling pathway Source: MGI
immune response Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5669034 TNFs bind their physiological receptors

Reactomeⁱ

R-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CD70 antigen Alternative name(s): CD27 ligand Short name: CD27-L Tumor necrosis factor ligand superfamily member 7 CD_antigen: CD70
Gene namesⁱ	Name:Cd70 Synonyms:Cd27l, Cd27lg, Tnfsf7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1195273 Cd70

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 23	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	24 – 44	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	45 – 195	ExtracellularSequence analysisAdd BLAST	151

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185498	1 – 195	CD70 antigenAdd BLAST		195

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	65	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	116	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	135 ↔ 153	Sequence analysis
Glycosylationⁱ	172	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O55237
PRIDEⁱ	O55237

PTM databases

PhosphoSitePlusⁱ	O55237

PhosphoSitePlusⁱ

O55237

Expressionⁱ

Tissue specificityⁱ

Very low level of expression. Detected in splenocytes and thymocytes.

Inductionⁱ

By IL-2 and concanavalin A (Con A).

Gene expression databases

Bgeeⁱ	ENSMUSG00000019489 Expressed in 14 organ(s), highest expression level in cerebellum
CleanExⁱ	MM_CD70
ExpressionAtlasⁱ	O55237 baseline and differential
Genevisibleⁱ	O55237 MM

Interactionⁱ

Subunit structureⁱ

Homotrimer.Curated

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
protease binding Source: MGI
tumor necrosis factor receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000019633

STRINGⁱ

10090.ENSMUSP00000019633

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O55237
SMRⁱ	O55237
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tumor necrosis factor family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IY7F Eukaryota ENOG41119T2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006744
HOGENOMⁱ	HOG000070045
HOVERGENⁱ	HBG054184
InParanoidⁱ	O55237
KEGG Orthology (KO) More...KOⁱ	K05470
OMAⁱ	QVTLANC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QAO
PhylomeDBⁱ	O55237
TreeFamⁱ	TF338269

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00184 TNF, 1 hit
Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50049 TNF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O55237-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPEEGRPCPW VRWSGTAFQR QWPWLLLVVF ITVFCCWFHC SGLLSKQQQR 
        60         70         80         90        100
LLEHPEPHTA ELQLNLTVPR KDPTLRWGAG PALGRSFTHG PELEEGHLRI 
       110        120        130        140        150
HQDGLYRLHI QVTLANCSSP GSTLQHRATL AVGICSPAAH GISLLRGRFG 
       160        170        180        190 
QDCTVALQRL TYLVHGDVLC TNLTLPLLPS RNADETFFGV QWICP

Length:195

Mass (Da):21,919

Last modified:June 1, 1998 - v1

Checksum:ⁱBD14671A2C8E26C7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y13637, Y13638 Genomic DNA Translation: CAA73977.1 Y13636 mRNA Translation: CAA73976.1 U78091 mRNA Translation: AAD00274.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28927.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035747.1, NM_011617.2
UniGeneⁱ	Mm.42228

Genome annotation databases

Ensemblⁱ	ENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489
GeneIDⁱ	21948
KEGGⁱ	mmu:21948
UCSC genome browser More...UCSCⁱ	uc008dee.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O55237	CD70 antigen		MOUSE		195	UniRef100_O55237

Protein	Similar proteins		Species	Score	Length	Source
O55237	CD70 antigen		MOUSE		195	UniRef90_O55237
UPI000A318A50		MUSCR		196

Protein	Similar proteins		Species	Score	Length	Source
O55237	CD70 antigen		MOUSE		195	UniRef50_O55237
UPI000A318A50		MUSCR		196
UPI000767248D		MYODS		154
UPI0007045814		MYOBR		165
UPI00062AC95D		OCTDE		175
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y13637, Y13638 Genomic DNA Translation: CAA73977.1 Y13636 mRNA Translation: CAA73976.1 U78091 mRNA Translation: AAD00274.1
CCDSⁱ	CCDS28927.1
RefSeqⁱ	NP_035747.1, NM_011617.2
UniGeneⁱ	Mm.42228

3D structure databases

ProteinModelPortalⁱ	O55237
SMRⁱ	O55237
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000019633

STRINGⁱ

10090.ENSMUSP00000019633

PTM databases

PhosphoSitePlusⁱ	O55237

PhosphoSitePlusⁱ

O55237

Proteomic databases

PaxDbⁱ	O55237
PRIDEⁱ	O55237

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489
GeneIDⁱ	21948
KEGGⁱ	mmu:21948
UCSCⁱ	uc008dee.1 mouse

Organism-specific databases

CTDⁱ	970
MGIⁱ	MGI:1195273 Cd70

Phylogenomic databases

eggNOGⁱ	ENOG410IY7F Eukaryota ENOG41119T2 LUCA
GeneTreeⁱ	ENSGT00390000006744
HOGENOMⁱ	HOG000070045
HOVERGENⁱ	HBG054184
InParanoidⁱ	O55237
KOⁱ	K05470
OMAⁱ	QVTLANC
OrthoDBⁱ	EOG091G0QAO
PhylomeDBⁱ	O55237
TreeFamⁱ	TF338269

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5669034 TNFs bind their physiological receptors

Reactomeⁱ

R-MMU-5669034 TNFs bind their physiological receptors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O55237
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019489 Expressed in 14 organ(s), highest expression level in cerebellum
CleanExⁱ	MM_CD70
ExpressionAtlasⁱ	O55237 baseline and differential
Genevisibleⁱ	O55237 MM

Family and domain databases

CDDⁱ	cd00184 TNF, 1 hit
Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50049 TNF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD70_MOUSE
Accessionⁱ	O55237Primary (citable) accession number: O55237
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O55237 (CD70_MOUSE)

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CD70 antigen

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ