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Protein

CD70 antigen

Gene

Cd70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name:
CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen: CD70
Gene namesi
Name:Cd70
Synonyms:Cd27l, Cd27lg, Tnfsf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1195273 Cd70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini45 – 195ExtracellularSequence analysisAdd BLAST151

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854981 – 195CD70 antigenAdd BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 153Sequence analysis
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55237
PRIDEiO55237

PTM databases

PhosphoSitePlusiO55237

Expressioni

Tissue specificityi

Very low level of expression. Detected in splenocytes and thymocytes.

Inductioni

By IL-2 and concanavalin A (Con A).

Gene expression databases

BgeeiENSMUSG00000019489 Expressed in 14 organ(s), highest expression level in cerebellum
CleanExiMM_CD70
ExpressionAtlasiO55237 baseline and differential
GenevisibleiO55237 MM

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019633

Structurei

3D structure databases

ProteinModelPortaliO55237
SMRiO55237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY7F Eukaryota
ENOG41119T2 LUCA
GeneTreeiENSGT00390000006744
HOGENOMiHOG000070045
HOVERGENiHBG054184
InParanoidiO55237
KOiK05470
OMAiQVTLANC
OrthoDBiEOG091G0QAO
PhylomeDBiO55237
TreeFamiTF338269

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

O55237-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEEGRPCPW VRWSGTAFQR QWPWLLLVVF ITVFCCWFHC SGLLSKQQQR
60 70 80 90 100
LLEHPEPHTA ELQLNLTVPR KDPTLRWGAG PALGRSFTHG PELEEGHLRI
110 120 130 140 150
HQDGLYRLHI QVTLANCSSP GSTLQHRATL AVGICSPAAH GISLLRGRFG
160 170 180 190
QDCTVALQRL TYLVHGDVLC TNLTLPLLPS RNADETFFGV QWICP
Length:195
Mass (Da):21,919
Last modified:June 1, 1998 - v1
Checksum:iBD14671A2C8E26C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13637, Y13638 Genomic DNA Translation: CAA73977.1
Y13636 mRNA Translation: CAA73976.1
U78091 mRNA Translation: AAD00274.1
CCDSiCCDS28927.1
RefSeqiNP_035747.1, NM_011617.2
UniGeneiMm.42228

Genome annotation databases

EnsembliENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489
GeneIDi21948
KEGGimmu:21948
UCSCiuc008dee.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13637, Y13638 Genomic DNA Translation: CAA73977.1
Y13636 mRNA Translation: CAA73976.1
U78091 mRNA Translation: AAD00274.1
CCDSiCCDS28927.1
RefSeqiNP_035747.1, NM_011617.2
UniGeneiMm.42228

3D structure databases

ProteinModelPortaliO55237
SMRiO55237
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019633

PTM databases

PhosphoSitePlusiO55237

Proteomic databases

PaxDbiO55237
PRIDEiO55237

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489
GeneIDi21948
KEGGimmu:21948
UCSCiuc008dee.1 mouse

Organism-specific databases

CTDi970
MGIiMGI:1195273 Cd70

Phylogenomic databases

eggNOGiENOG410IY7F Eukaryota
ENOG41119T2 LUCA
GeneTreeiENSGT00390000006744
HOGENOMiHOG000070045
HOVERGENiHBG054184
InParanoidiO55237
KOiK05470
OMAiQVTLANC
OrthoDBiEOG091G0QAO
PhylomeDBiO55237
TreeFamiTF338269

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Miscellaneous databases

PROiPR:O55237
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019489 Expressed in 14 organ(s), highest expression level in cerebellum
CleanExiMM_CD70
ExpressionAtlasiO55237 baseline and differential
GenevisibleiO55237 MM

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD70_MOUSE
AccessioniPrimary (citable) accession number: O55237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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