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Protein

Cerberus

Gene

Cer1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part, through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.4 Publications

GO - Molecular functioni

  • BMP binding Source: MGI
  • cytokine activity Source: UniProtKB-KW
  • morphogen activity Source: MGI
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Cerberus
Alternative name(s):
Cerberus-like protein
Short name:
Cer-l
Cerberus-related protein
Gene namesi
Name:Cer1
Synonyms:Cerl, Cerr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1201414 Cer1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000000671218 – 272CerberusAdd BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi162 ↔ 209PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi176 ↔ 223PROSITE-ProRule annotation
Disulfide bondi186 ↔ 239PROSITE-ProRule annotation
Disulfide bondi190 ↔ 241PROSITE-ProRule annotation
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55233
PRIDEiO55233

PTM databases

iPTMnetiO55233
PhosphoSitePlusiO55233

Expressioni

Developmental stagei

At E6.5., early and mid-streak stage embryos, was expressed in the anterior visceral endoderm. The expression domain extended from the extraembryonic-embryonic junction to approximately two thirds of the way down the epiblast. By the mid-streak to late streak stage, expressed in the anterior visceral endoderm but was also expressed in the definitive endoderm emanating from the anterior portion of the primitive streak. By the neural plate stage at E7.5 expression was present throughout the anterior definitive endoderm layer including both the midline and anterior lateral endoderm. At the early headfold stage expression was reduced in the anterior lateral region and expression was seen primarily in the foregut endoderm. In early E8.5 embryos expression was restricted to the two most recently formed somites. In E9 and E9.5 embryos expression continued in the two newest formed somites and also in the anterior presomitic mesoderm.3 Publications

Gene expression databases

BgeeiENSMUSG00000038192 Expressed in 55 organ(s), highest expression level in retina
CleanExiMM_CER1
ExpressionAtlasiO55233 baseline and differential
GenevisibleiO55233 MM

Interactioni

Subunit structurei

Forms monomers and predominantly dimers.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198677, 1 interactor
STRINGi10090.ENSMUSP00000048607

Structurei

3D structure databases

ProteinModelPortaliO55233
SMRiO55233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 246CTCKPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGR5 Eukaryota
ENOG410YX4Y LUCA
GeneTreeiENSGT00530000063926
HOGENOMiHOG000231309
HOVERGENiHBG050902
InParanoidiO55233
KOiK01645
OMAiCFGKCGS
OrthoDBiEOG091G0IOA
PhylomeDBiO55233
TreeFamiTF106445

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR016860 Cerberus
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
PANTHERiPTHR15273 PTHR15273, 1 hit
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF027807 Cerberus, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55233-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLLVQLLV LLPLGKADLC VDGCQSQGSL SFPLLERGRR DLHVANHEEA
60 70 80 90 100
EDKPDLFVAV PHLMGTSLAG EGQRQRGKML SRLGRFWKKP ETEFYPPRDV
110 120 130 140 150
ESDHVSSGMQ AVTQPADGRK VERSPLQEEA KRFWHRFMFR KGPAFQGVIL
160 170 180 190 200
PIKSHEVHWE TCRTVPFNQT IAHEDCQKVV VQNNLCFGKC SSIRFPGEGA
210 220 230 240 250
DAHSFCSHCS PTKFTTVHLM LNCTSPTPVV KMVMQVEECQ CMVKTERGEE
260 270
RLLLAGSQGS FIPGLPASKT NP
Length:272
Mass (Da):30,431
Last modified:June 1, 1998 - v1
Checksum:iDD0842A2619AF057
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220M → R in AAB71838 (PubMed:9431803).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012244 Genomic DNA Translation: AAB71838.1
AF035579 mRNA Translation: AAC02430.1
AF031896 mRNA Translation: AAC24461.1
CCDSiCCDS18295.1
RefSeqiNP_034017.1, NM_009887.2
UniGeneiMm.6780

Genome annotation databases

EnsembliENSMUST00000048430; ENSMUSP00000048607; ENSMUSG00000038192
GeneIDi12622
KEGGimmu:12622
UCSCiuc008tkl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012244 Genomic DNA Translation: AAB71838.1
AF035579 mRNA Translation: AAC02430.1
AF031896 mRNA Translation: AAC24461.1
CCDSiCCDS18295.1
RefSeqiNP_034017.1, NM_009887.2
UniGeneiMm.6780

3D structure databases

ProteinModelPortaliO55233
SMRiO55233
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198677, 1 interactor
STRINGi10090.ENSMUSP00000048607

PTM databases

iPTMnetiO55233
PhosphoSitePlusiO55233

Proteomic databases

PaxDbiO55233
PRIDEiO55233

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048430; ENSMUSP00000048607; ENSMUSG00000038192
GeneIDi12622
KEGGimmu:12622
UCSCiuc008tkl.2 mouse

Organism-specific databases

CTDi9350
MGIiMGI:1201414 Cer1

Phylogenomic databases

eggNOGiENOG410IGR5 Eukaryota
ENOG410YX4Y LUCA
GeneTreeiENSGT00530000063926
HOGENOMiHOG000231309
HOVERGENiHBG050902
InParanoidiO55233
KOiK01645
OMAiCFGKCGS
OrthoDBiEOG091G0IOA
PhylomeDBiO55233
TreeFamiTF106445

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP

Miscellaneous databases

PROiPR:O55233
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038192 Expressed in 55 organ(s), highest expression level in retina
CleanExiMM_CER1
ExpressionAtlasiO55233 baseline and differential
GenevisibleiO55233 MM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR016860 Cerberus
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
PANTHERiPTHR15273 PTHR15273, 1 hit
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF027807 Cerberus, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCER1_MOUSE
AccessioniPrimary (citable) accession number: O55233
Secondary accession number(s): O35213
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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