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Entry version 130 (25 May 2022)
Sequence version 3 (18 Sep 2019)
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Protein

Otogelin

Gene

Otog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Otogelin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Otog
Synonyms:Otgn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1202064, Otog

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000009487

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impaired vestibular and auditory functions.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031214926 – 2911OtogelinSequence analysisAdd BLAST2886

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi93 ↔ 107PROSITE-ProRule annotation
Disulfide bondi101 ↔ 113PROSITE-ProRule annotation
Disulfide bondi115 ↔ 125PROSITE-ProRule annotation
Disulfide bondi139 ↔ 272PROSITE-ProRule annotation
Disulfide bondi186 ↔ 193PROSITE-ProRule annotation
Disulfide bondi501 ↔ 639PROSITE-ProRule annotation
Disulfide bondi523 ↔ 674PROSITE-ProRule annotation
Disulfide bondi545 ↔ 553PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi800N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi973 ↔ 1102PROSITE-ProRule annotation
Disulfide bondi1017 ↔ 1024PROSITE-ProRule annotation
Glycosylationi1465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2060N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2098 ↔ 2235PROSITE-ProRule annotation
Disulfide bondi2826 ↔ 2875PROSITE-ProRule annotation
Disulfide bondi2840 ↔ 2889PROSITE-ProRule annotation
Disulfide bondi2851 ↔ 2906PROSITE-ProRule annotation
Disulfide bondi2855 ↔ 2908PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. Not O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O55225

PRoteomics IDEntifications database

More...
PRIDEi
O55225

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O55225, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O55225

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O55225

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in neuroepithelial supporting cells of the inner ear. Expressed in the cochlea between postnatal day P0 and P6 in pseudostratified cells of the greater epithelial ridge, in supporting cells of the neuroepithelium comprising Deiter's, Hensen's, pillar and Claudius cells, in epithelial cells of the Reissner's membrane, in a small set of cells comprising the spiral prominence. Expressed in the cochlea at P15 in interdental cells located underneath the limbal part of the tectorial membrane. Expressed in the vestibular apparatus at P0 in supporting cells of the saccular, utricular maculae and cristae ampullares, in the epithelial cells of the roof of the saccule but not in the roof of the utricle and cristae ampullares (at protein level). Expressed in the cochlea and vestibular organ of the inner ear.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the epithelial cells of the otic vesicle at 10 dpc. Expressed in non-sensory cells of the developing vestibule, in the transitory epithelium of the saccule, utricle and cristae ampullares, in epithelial cells of the roof of the saccule, but not the roof of the utricle nor the cristae ampullares at 13 dpc. Expressed in supporting cells of the vestibular maculae at 13 dpc onward birth. Expressed in non-sensory cells of the emerging cochlear duct at 12 dpc. Expressed in the pluristratified sensory epithelium as well as in the epithelium of the roof at 14 dpc. Expressed in the developing sensory epithelium (the spiral limbus, the greater epithelial ridge and the lesser epithelial ridge) of the cochlear duct, the interdental cells of the spiral limbus and in the columnar cells that form the greater epithelial ridge at 16 and 17 dpc. Expressed in the non-sensory pillar, Deiter's and Hensen's cells of the organ of Corti and Claudius cells at 19 dpc onward birth (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000009487, Expressed in saccule of membranous labyrinth and 38 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130949

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O55225, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O55225

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 126EGF-likePROSITE-ProRule annotationAdd BLAST38
Domaini137 – 309VWFD 1PROSITE-ProRule annotationAdd BLAST173
Domaini499 – 675VWFD 2PROSITE-ProRule annotationAdd BLAST177
Domaini767 – 831TILSequence analysisAdd BLAST65
Domaini971 – 1140VWFD 3PROSITE-ProRule annotationAdd BLAST170
Domaini2096 – 2276VWFD 4PROSITE-ProRule annotationAdd BLAST181
Domaini2826 – 2911CTCKPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1456 – 1541DisorderedSequence analysisAdd BLAST86
Regioni1683 – 1702DisorderedSequence analysisAdd BLAST20
Regioni1719 – 1785DisorderedSequence analysisAdd BLAST67
Regioni1859 – 1880DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1465 – 1488Polar residuesSequence analysisAdd BLAST24
Compositional biasi1495 – 1509Pro residuesSequence analysisAdd BLAST15
Compositional biasi1517 – 1541Polar residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the otogelin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157490

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000076_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O55225

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMFGNSW

Database of Orthologous Groups

More...
OrthoDBi
12226at2759

TreeFam database of animal gene trees

More...
TreeFami
TF330609

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007934, AbfB_ABD
IPR036195, AbfB_ABD_sf
IPR006207, Cys_knot_C
IPR000742, EGF-like_dom
IPR030105, Otogelin
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF228, PTHR11339:SF228, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05270, AbfB, 1 hit
PF08742, C8, 4 hits
PF01826, TIL, 1 hit
PF00094, VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110221, SSF110221, 1 hit
SSF57567, SSF57567, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01225, CTCK_2, 1 hit
PS50026, EGF_3, 1 hit
PS51233, VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O55225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGARMPRRCL LLLSCFCLLR VESTAEVQHQ ASALTWKISA ELQQEPAPEP
60 70 80 90 100
SHTYQEMSLA VEDVTTVMEG QEAEALAASA MSSWERRLHR AKCAPSYLFS
110 120 130 140 150
CFNGGECVHP ALCDCRRFNA TGPRCQLVYN VGPERDSICR TWGQHHVETF
160 170 180 190 200
DGLYYYFSGK GSYTLVGHHE PEGQSFSIQV HNDPQCGSAH YTCPRSVSLF
210 220 230 240 250
LSGEREICLA KEVTHGGVRV QLPQVVGGVQ LQQLAGYVIA RHPSAFTLAW
260 270 280 290 300
DGISAIYIKM SPEFLGWTHG LCGNNNADPQ DDLVTSYGKV TDDVGEFVHS
310 320 330 340 350
WQEQVPNSPP GPVTTSLPRP PCLQQSPASM QGVYERCEVL LRPPFDTCHA
360 370 380 390 400
YVSPLPFAAS CTSDLCQSGG DEATWCRALM EYARACAQAG RPLQGWRTQL
410 420 430 440 450
SQCTVHCKEK AFIYNECIAC CPASCQSRAS CVDSEITCVD GCYCPNGLIF
460 470 480 490 500
EDGGCMSPAE CPCEFHGTLH PPGSVVTEDC NACTCTAGKW VCSSSVCPAE
510 520 530 540 550
CSVTGDIHFT TFDGRRYTFP ATCQYILAKS RSSGTFTVTL QNAPCGLNQD
560 570 580 590 600
GACVQSVSVI LHQDPRRQVT LTQAGDVLLF DQYKITPPYS DDAFEIRRLS
610 620 630 640 650
SVFLRVRTNV GVRILYDREG LRLYLQVDQR WVEDTVGLCG TFNGNTQDDF
660 670 680 690 700
LSPVGVPEST PQLFGNSWKT LSACVPLVPG SLLDPCDVHL QAASYALQSC
710 720 730 740 750
SVLTGELFAP CSAYLSPIPY FEQCRRDACR CGQPCLCATL AHYARLCRRH
760 770 780 790 800
GLPVDFRAHL PACALSCEAT KEYSPCVTLC APTCQDLASP DVCGANGGGN
810 820 830 840 850
FSREECVEGC TCPPDTFLDT QADLCVPRNQ CSCHFQGVDY PPGDSDIPSL
860 870 880 890 900
GHCHCKDGVM SCDSRAPAAA CPAGQVFVNC SELHPDPELS RERTCEQQLL
910 920 930 940 950
NLSVPARGPC LSGCACPQGL LRHGDACFPP EECPCTWKGK EYFPGDQVVS
960 970 980 990 1000
SCHTCVCQRG SFQCTLHPCA STCTAYGDRH YRTFDGLPYD FVGACKVHLV
1010 1020 1030 1040 1050
KSTSELSFSV MVEDVNCYGS GVICRKSISI NVGSSLIIFD DDSGDPSPES
1060 1070 1080 1090 1100
FLDEKQAVHI WRAGFFTLVH FPREHITLLW DQRTTVHVQA GPQWQGQLVG
1110 1120 1130 1140 1150
LCGNFDLKTI NEMRTPENLE LTNPQEFGSS WAAVECPDTP DPRDTCVLNP
1160 1170 1180 1190 1200
LREPFARKEC GILLSEVFET CHPVVDVTWF YSNCLTDTCG CSRGGDCECF
1210 1220 1230 1240 1250
CASVAAYAHQ CCQHGVVIDW RTPRICPYDC DFFNKALGKG PYQLSSVAAG
1260 1270 1280 1290 1300
GTLVATKAVD SDIALVRAED LAPGDISSFL LTAALYKAKA HDPDVVSLEA
1310 1320 1330 1340 1350
ADRPNFFLHT TANGSIGLAK WQRDEAFHQH ASFSLHRGTW QAGLVALESL
1360 1370 1380 1390 1400
AKPGSFLHSS GLELALRAYE HTEVFRGGAL FRLLDAKPLG AAYPTCEWRY
1410 1420 1430 1440 1450
DACASPCFQT CRDPRATSCQ DVPRVEGCVP VCPTPKVLDE VTQRCVYLED
1460 1470 1480 1490 1500
CVEPAPRGPT ETLGNETLVP GQVPPTTSAE QQLPQGLPGA SAYSPAPVPV
1510 1520 1530 1540 1550
APPTSAPNPP MAATEGQAPS PGSTQPTLQT PLGLTTSNFP AGHTEATARE
1560 1570 1580 1590 1600
EGAASLLTTS HPPGFSSSLP SSLQMPTSGI VSGATETTKV TITFTGSPNT
1610 1620 1630 1640 1650
TVASRSPPIP RFPLMTKAVT VPSHDSFPVK TTPLQPSWLW SLSSRPMTSL
1660 1670 1680 1690 1700
GATSWPPTSP GSHLSTAVTK VANKTMTSLS VLAQSTSSSS QPLAAVTTAH
1710 1720 1730 1740 1750
RAPASPLVTK GLEVVSATEK GEAGHSQLTE LPVSPPPSPA PIDLPHPAQH
1760 1770 1780 1790 1800
TTTAPGPSAL SPGILAAGSP STGAHRPGAT ALASLEPTRP PHLLSGLPLD
1810 1820 1830 1840 1850
TSLPLAKVGT SAPVATPGSK GYIPTPPPQH QATTLATAMT VSPLTQSLSL
1860 1870 1880 1890 1900
TVPLMSAVEE QAHSPSPKPP QGTGMAPDQM LGATLPSFGA SSVIAGVPPT
1910 1920 1930 1940 1950
VSAAPRKSTT QRAAILSKKV SPPTLISDSV QGGFTELTPI VSHTVTPLAT
1960 1970 1980 1990 2000
EAEGPRAGTV PLVPTTYSLS RVSARTASRE GPLVLLPQLA EAYGTPAGLQ
2010 2020 2030 2040 2050
PQEDLVRQAT TEQSGRSAPA KSIAEESMEA EVNTSATCVP IAEQDCVRHI
2060 2070 2080 2090 2100
CLEGQLIRVN QTQHCPQGAV RPRCGVLGLA VRVGGDRCCP QWECACRCSI
2110 2120 2130 2140 2150
FPDLSFVTFD GSHAALFKEA IYVLSQSPDE TISVHVLDCK SANLGHLNWP
2160 2170 2180 2190 2200
PFCLVILNVT HLAHHVSIDR FNRKVTVDSQ VVWPPMSRYG FRIEDTGHMY
2210 2220 2230 2240 2250
IVRTPSHIQI QWLHSSGLMI LEASKVSKTQ GHGLCGICDG DAANDLTLKD
2260 2270 2280 2290 2300
GSVLGEAEDP APFLDSWQVP SSLTSEGQTR FRPDSCATAD CSPCLRMVSN
2310 2320 2330 2340 2350
RTFSACHSFV SPESFCELWI RDTKYVQQPC VALTVYVAMC HKFHVCIEWR
2360 2370 2380 2390 2400
GSDYCPFLCS SDSTYQACVA ACEPPDTCQD GILGPLDPEQ CQVLGEGCVC
2410 2420 2430 2440 2450
TEGTILHRRH SALCIPEDKC ACTDSTGVPR ALGETWNSSL SGCCQQQCQA
2460 2470 2480 2490 2500
PDTIIPVDLD CPGPRPESCP RFGEVILLQP TEDPCCLGSV CVCNQTLCEG
2510 2520 2530 2540 2550
LAPTCRPGHS LITHFQEDSC CPSYSCECDP GLCEAEQVPT CREDQILIEG
2560 2570 2580 2590 2600
RLGDSCCTSY FCGCGECSDP MPECQEGEAL TVHRNTTELC CPLYQCVCEN
2610 2620 2630 2640 2650
FRCPQVQCGM GTSLVEVWSP DRCCPYKSCE CDCDTIPVPR CHLWEKSQLD
2660 2670 2680 2690 2700
EEFMHSVENV CGCAKYECVK APVCLSRELG VMQPGQTVVE LSADGVCHTS
2710 2720 2730 2740 2750
RCTDVLDPLT NFYQINITSV LCDMHCEANQ EYDHPRDLAA CCGSCRNVSC
2760 2770 2780 2790 2800
LFTFPNGTTS LFLPGASWIA DCARHHCGST PLGAVLVRSP ISCPPFNETE
2810 2820 2830 2840 2850
CAKVGGSVVP SLEGCCRACK EDGRSCKKVT IRMTIRKNDC RSNTPVNLVS
2860 2870 2880 2890 2900
CDGRCPSASI YNHNINTYAR FCKCCREVGL QRRSVQLFCA TNATWVPYTV
2910
QEPTDCACQW S
Length:2,911
Mass (Da):313,620
Last modified:September 18, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59A234779D0BC296
GO
Isoform 2 (identifier: O55225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-693: SPVGVPESTP...DPCDVHLQAA → YVSLPCDRKE...THTHTHTHTT
     694-2911: Missing.

Show »
Length:693
Mass (Da):76,556
Checksum:i40A72F6D8130D2CA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSE0A0A1B0GSE0_MOUSE
Otogelin
Otog
726Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti547L → P in AAB96561 (PubMed:9405633).Curated1
Sequence conflicti904V → M in AAB96561 (PubMed:9405633).Curated1
Sequence conflicti1143R → G in AAB96561 (PubMed:9405633).Curated1
Sequence conflicti1424 – 1427RVEG → GRS in AAB96561 (PubMed:9405633).Curated4
Sequence conflicti2006V → M in AAB96561 (PubMed:9405633).Curated1
Sequence conflicti2021K → Q in AAB96561 (PubMed:9405633).Curated1
Sequence conflicti2048R → H in AAB96561 (PubMed:9405633).Curated1
Sequence conflicti2201I → M in AAB96561 (PubMed:9405633).Curated1
Sequence conflicti2382I → V in AAB96561 (PubMed:9405633).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029715652 – 693SPVGV…HLQAA → YVSLPCDRKERETHGPLRVC IQRHCLTQTQTHTHTHTHTH TT in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_029716694 – 2911Missing in isoform 2. 1 PublicationAdd BLAST2218

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U96411 mRNA Translation: AAB96561.1
AK165831 mRNA Translation: BAE38401.1
AC020786 Genomic DNA No translation available.
AC120135 Genomic DNA No translation available.
CH466603 Genomic DNA Translation: EDL22925.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52251.1 [O55225-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42214

NCBI Reference Sequences

More...
RefSeqi
NP_038652.2, NM_013624.2 [O55225-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000164538; ENSMUSP00000130949; ENSMUSG00000009487 [O55225-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18419

UCSC genome browser

More...
UCSCi
uc009gyi.1, mouse [O55225-2]
uc009gyk.2, mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96411 mRNA Translation: AAB96561.1
AK165831 mRNA Translation: BAE38401.1
AC020786 Genomic DNA No translation available.
AC120135 Genomic DNA No translation available.
CH466603 Genomic DNA Translation: EDL22925.1
CCDSiCCDS52251.1 [O55225-1]
PIRiT42214
RefSeqiNP_038652.2, NM_013624.2 [O55225-1]

3D structure databases

SMRiO55225
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130949

PTM databases

GlyGeniO55225, 3 sites
iPTMnetiO55225
PhosphoSitePlusiO55225

Proteomic databases

PaxDbiO55225
PRIDEiO55225

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
77421, 8 antibodies from 2 providers

The DNASU plasmid repository

More...
DNASUi
18419

Genome annotation databases

EnsembliENSMUST00000164538; ENSMUSP00000130949; ENSMUSG00000009487 [O55225-1]
GeneIDi18419
KEGGimmu:18419
UCSCiuc009gyi.1, mouse [O55225-2]
uc009gyk.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340990
MGIiMGI:1202064, Otog
VEuPathDBiHostDB:ENSMUSG00000009487

Phylogenomic databases

eggNOGiKOG1216, Eukaryota
GeneTreeiENSGT00940000157490
HOGENOMiCLU_000076_0_0_1
InParanoidiO55225
OMAiEMFGNSW
OrthoDBi12226at2759
TreeFamiTF330609

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18419, 0 hits in 72 CRISPR screens

Protein Ontology

More...
PROi
PR:O55225
RNActiO55225, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000009487, Expressed in saccule of membranous labyrinth and 38 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR007934, AbfB_ABD
IPR036195, AbfB_ABD_sf
IPR006207, Cys_knot_C
IPR000742, EGF-like_dom
IPR030105, Otogelin
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
PANTHERiPTHR11339:SF228, PTHR11339:SF228, 1 hit
PfamiView protein in Pfam
PF05270, AbfB, 1 hit
PF08742, C8, 4 hits
PF01826, TIL, 1 hit
PF00094, VWD, 4 hits
SMARTiView protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits
SUPFAMiSSF110221, SSF110221, 1 hit
SSF57567, SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS01225, CTCK_2, 1 hit
PS50026, EGF_3, 1 hit
PS51233, VWFD, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTOG_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O55225
Secondary accession number(s): E9QMN3, G3UWC8, Q3TMP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 18, 2019
Last modified: May 25, 2022
This is version 130 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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