UniProtKB - O55208 (FIGLA_MOUSE)
Factor in the germline alpha
Figla
Functioni
Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
1 PublicationGO - Molecular functioni
- bHLH transcription factor binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- E-box binding Source: Ensembl
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- developmental process Source: GO_Central
- oogenesis Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Oogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Factor in the germline alphaShort name: FIGalpha Alternative name(s): Transcription factor FIGa |
Gene namesi | Name:Figla |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1349421, Figla |
VEuPathDBi | HostDB:ENSMUSG00000030001 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127180 | 1 – 194 | Factor in the germline alphaAdd BLAST | 194 |
Proteomic databases
PaxDbi | O55208 |
PRIDEi | O55208 |
PTM databases
PhosphoSitePlusi | O55208 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000030001, Expressed in primary oocyte and 46 other tissues |
ExpressionAtlasi | O55208, baseline and differential |
Genevisiblei | O55208, MM |
Interactioni
Subunit structurei
Heterodimer with TCF3/isoform E12.
GO - Molecular functioni
- bHLH transcription factor binding Source: UniProtKB
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000032070 |
Miscellaneous databases
RNActi | O55208, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 111 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 163 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 135 – 158 | Polar residuesSequence analysisAdd BLAST | 24 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00440000033552 |
HOGENOMi | CLU_1380972_0_0_1 |
InParanoidi | O55208 |
OMAi | ELAHTCR |
OrthoDBi | 1245774at2759 |
PhylomeDBi | O55208 |
TreeFami | TF351992 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDTAPASPEP FLVTPQAEVL EELIQAQMGP LPRLAAICRL KRLPSGGYST
60 70 80 90 100
TDDLHLVLER RRVANAKERE RIKNLNRGFA KLKALVPFLP QSRKPSKVDI
110 120 130 140 150
LKGATEYIQI LGCVLEEAKV SEKQSPEEQT HSGRPSDPHV SSTRELLGNA
160 170 180 190
TQPTSCASGL KKEEEGPWAY AGHSEPLYSY HQSTVPETRS YFTH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91840 mRNA Translation: AAB97139.1 |
CCDSi | CCDS20307.1 |
RefSeqi | NP_036143.1, NM_012013.2 |
Genome annotation databases
Ensembli | ENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001 |
GeneIDi | 26910 |
KEGGi | mmu:26910 |
UCSCi | uc009crb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91840 mRNA Translation: AAB97139.1 |
CCDSi | CCDS20307.1 |
RefSeqi | NP_036143.1, NM_012013.2 |
3D structure databases
AlphaFoldDBi | O55208 |
SMRi | O55208 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000032070 |
PTM databases
PhosphoSitePlusi | O55208 |
Proteomic databases
PaxDbi | O55208 |
PRIDEi | O55208 |
Protocols and materials databases
Antibodypediai | 31154, 81 antibodies from 18 providers |
DNASUi | 26910 |
Genome annotation databases
Ensembli | ENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001 |
GeneIDi | 26910 |
KEGGi | mmu:26910 |
UCSCi | uc009crb.1, mouse |
Organism-specific databases
CTDi | 344018 |
MGIi | MGI:1349421, Figla |
VEuPathDBi | HostDB:ENSMUSG00000030001 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00440000033552 |
HOGENOMi | CLU_1380972_0_0_1 |
InParanoidi | O55208 |
OMAi | ELAHTCR |
OrthoDBi | 1245774at2759 |
PhylomeDBi | O55208 |
TreeFami | TF351992 |
Miscellaneous databases
BioGRID-ORCSi | 26910, 2 hits in 70 CRISPR screens |
PROi | PR:O55208 |
RNActi | O55208, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030001, Expressed in primary oocyte and 46 other tissues |
ExpressionAtlasi | O55208, baseline and differential |
Genevisiblei | O55208, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FIGLA_MOUSE | |
Accessioni | O55208Primary (citable) accession number: O55208 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot