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Protein

Factor in the germline alpha

Gene

Figla

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Oogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Factor in the germline alpha
Short name:
FIGalpha
Alternative name(s):
Transcription factor FIGa
Gene namesi
Name:Figla
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1349421 Figla

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Females display a defect in the formation of primordial follicles leading to infertility. Although embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massive depletion of oocytes resulted in shrunken ovaries and female sterility. Null females do not express ZP1, ZP2 or ZP3. Since its expression is oocyte-specific in females, Figla is a plausible candidate gene for primary ovarian failure in otherwise phenotypically normal women. The gene for Figla null males have normal fertility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271801 – 194Factor in the germline alphaAdd BLAST194

Proteomic databases

PaxDbiO55208
PRIDEiO55208

PTM databases

PhosphoSitePlusiO55208

Expressioni

Tissue specificityi

Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels.

Developmental stagei

Detected as early as embryonic day 13, shortly after the onset of sexual dimorphism of the gonads. Dramatically increases at the end of the embryonic development and peaks at 2 dpp, a time in ovarian development at which oocytes have become enclosed in primordial follicles. Decreases markedly by 7 and 14 days after birth. Persists, but at low level, in adult females. Not detected in male embryos, but detected in adult testes.1 Publication

Gene expression databases

BgeeiENSMUSG00000030001 Expressed in 21 organ(s), highest expression level in primary oocyte
CleanExiMM_FIGLA
ExpressionAtlasiO55208 baseline and differential
GenevisibleiO55208 MM

Interactioni

Subunit structurei

Heterodimer with TCF3/isoform E12.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032070

Structurei

3D structure databases

ProteinModelPortaliO55208
SMRiO55208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 111bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00440000033552
HOGENOMiHOG000112589
HOVERGENiHBG051616
InParanoidiO55208
KOiK09066
OMAiITQHASC
OrthoDBiEOG091G0WBZ
PhylomeDBiO55208
TreeFamiTF351992

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

O55208-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTAPASPEP FLVTPQAEVL EELIQAQMGP LPRLAAICRL KRLPSGGYST
60 70 80 90 100
TDDLHLVLER RRVANAKERE RIKNLNRGFA KLKALVPFLP QSRKPSKVDI
110 120 130 140 150
LKGATEYIQI LGCVLEEAKV SEKQSPEEQT HSGRPSDPHV SSTRELLGNA
160 170 180 190
TQPTSCASGL KKEEEGPWAY AGHSEPLYSY HQSTVPETRS YFTH
Length:194
Mass (Da):21,529
Last modified:June 1, 1998 - v1
Checksum:iB12137E37AF22723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91840 mRNA Translation: AAB97139.1
CCDSiCCDS20307.1
RefSeqiNP_036143.1, NM_012013.2
UniGeneiMm.8024

Genome annotation databases

EnsembliENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001
GeneIDi26910
KEGGimmu:26910
UCSCiuc009crb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91840 mRNA Translation: AAB97139.1
CCDSiCCDS20307.1
RefSeqiNP_036143.1, NM_012013.2
UniGeneiMm.8024

3D structure databases

ProteinModelPortaliO55208
SMRiO55208
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032070

PTM databases

PhosphoSitePlusiO55208

Proteomic databases

PaxDbiO55208
PRIDEiO55208

Protocols and materials databases

DNASUi26910
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032070; ENSMUSP00000032070; ENSMUSG00000030001
GeneIDi26910
KEGGimmu:26910
UCSCiuc009crb.1 mouse

Organism-specific databases

CTDi344018
MGIiMGI:1349421 Figla

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00440000033552
HOGENOMiHOG000112589
HOVERGENiHBG051616
InParanoidiO55208
KOiK09066
OMAiITQHASC
OrthoDBiEOG091G0WBZ
PhylomeDBiO55208
TreeFamiTF351992

Miscellaneous databases

PROiPR:O55208
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030001 Expressed in 21 organ(s), highest expression level in primary oocyte
CleanExiMM_FIGLA
ExpressionAtlasiO55208 baseline and differential
GenevisibleiO55208 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFIGLA_MOUSE
AccessioniPrimary (citable) accession number: O55208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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