UniProtKB - O55196 (ENAM_MOUSE)
Protein
Enamelin
Gene
Enam
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.By similarity
GO - Molecular functioni
- structural constituent of tooth enamel Source: MGI
GO - Biological processi
- ameloblast differentiation Source: MGI
- amelogenesis Source: MGI
- biomineral tissue development Source: UniProtKB-KW
- odontogenesis of dentin-containing tooth Source: MGI
- positive regulation of enamel mineralization Source: MGI
- regulation of cell morphogenesis Source: MGI
Keywordsi
Biological process | Biomineralization |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Enamelin |
Gene namesi | Name:Enam |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1333772, Enam |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- extracellular matrix Source: MGI
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 38 | Sequence analysisAdd BLAST | 38 | |
ChainiPRO_0000021175 | 39 – 1274 | EnamelinAdd BLAST | 1236 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 130 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 196 | PhosphoserineBy similarity | 1 | |
Modified residuei | 219 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 252 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 259 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1066 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated by FAM20C in vitro.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | O55196 |
PRIDEi | O55196 |
PTM databases
GlyGeni | O55196, 6 sites |
iPTMneti | O55196 |
PhosphoSitePlusi | O55196 |
Expressioni
Tissue specificityi
Expressed in developing teeth.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029286, Expressed in molar tooth and 24 other tissues |
Genevisiblei | O55196, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 199447, 1 interactor |
STRINGi | 10090.ENSMUSP00000031222 |
Miscellaneous databases
RNActi | O55196, protein |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502R69E, Eukaryota |
GeneTreei | ENSGT00440000037826 |
HOGENOMi | CLU_280412_0_0_1 |
InParanoidi | O55196 |
OMAi | WNSWDHR |
OrthoDBi | 201332at2759 |
PhylomeDBi | O55196 |
TreeFami | TF337278 |
Family and domain databases
InterProi | View protein in InterPro IPR015673, Enamelin |
PANTHERi | PTHR16784, PTHR16784, 2 hits |
Pfami | View protein in Pfam PF15362, Enamelin, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O55196-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLQCRNPT SPPKPCGLVP NVKMSLLVFL GLLGVSAAMP FQMPMPRMPG
60 70 80 90 100
FSSKSEEMMR YNQFNFMNAP PMMPMGPYGN GMPMPPHMPP QYPPYQMPMW
110 120 130 140 150
PPPVPNGWQQ PPMPNFPSKT DQTQETAKPN QTNPQEPQPQ KQPLKEPPNE
160 170 180 190 200
AARAKDDAQP PQPFPPFGNG LYPYPQPPWP IPQRGPPTAF GRPKFSNEEG
210 220 230 240 250
NPYYAFFGYH GFGGRPYYSE EMFEDYEKPK EKDPPKPEDP PPDDPPPEAS
260 270 280 290 300
TNSTVPDANA TQSIPEGGND TSPIGNTGPG PNAGNNPTVQ NGVFPPPKVN
310 320 330 340 350
VSGQGVPKSQ IPWRPSQPNI YENYPYPNYP SERQWQTTGT QGPRQNGPGY
360 370 380 390 400
RNPQVERGPQ WNSFAWEGKQ ATRPGNPTYG KPPSPTSGVN YAGNPVHFGR
410 420 430 440 450
NLPGPNKPFV GANPASNKPF VGANPASNKP FVGANPASNK PFVGANPASN
460 470 480 490 500
KPFVGANPAS NKPYVGANPA SNKPFIGANP AANKPSIGTN PAANKPSIGT
510 520 530 540 550
NPAANKPFVR NNVGANKPFV GTNPSSNQPF LRSNQASNKP FMRSNQASNK
560 570 580 590 600
PFVGTNVASV GPKQVTVSHN MKTQNPKEKS LGQKERTVTP TKDASNPWRS
610 620 630 640 650
AKQYGINNPN YNLPRSEGSM VGPNFNSFDQ QENSYFSKGA SKRVPSPNIQ
660 670 680 690 700
IQSQNLPKGI ALEPRRTPFQ SETKKPELKH GTHQPAYPKK IPSPTRKHFP
710 720 730 740 750
AERNTWNRQK ILPPLKEDYG RQDENLRHPS YGSRGNIFYH EYTNPYHNEK
760 770 780 790 800
SQYIKSNPWD KSSPSTMMRP ENPQYTMTSL DQKETEQYNE EDPIDPNEDE
810 820 830 840 850
SFPGQSRWGD EEMNFKGNPT VRQYEGEHYA STLAKEYLPY SLSNPPKPSE
860 870 880 890 900
DFPYSEFYPW NPQETFPIYN PGPTIAPPVD PRSYYVNNAI GQEESTLFPS
910 920 930 940 950
WTSWDHRNQA ERQKESEPYF NRNVWDQSIN LHKSNIPNHP YSTTSPARFP
960 970 980 990 1000
KDPTWFEGEN LNYDLQITSL SPPEREQLAF PDFLPQSYPT GQNEAHLFHQ
1010 1020 1030 1040 1050
SQRGSCCIGG STGHKDNVLA LQDYTSSYGL PPRKNQETSP VHTESSYIKY
1060 1070 1080 1090 1100
ARPNVSPASI LPSQRNISEN KLTAESPNPS PFGDGVPTVR KNTPYSGKNQ
1110 1120 1130 1140 1150
LETGIVAFSE ASSSQPKNTP CLKSDLGGDR RDVLKQFFEG SQLSERTAGL
1160 1170 1180 1190 1200
TPEQLVIGIP DKGSGPDSIQ SEVQGKEGEM QQQRPPTIMK LPCFGSNSKF
1210 1220 1230 1240 1250
HSSTTGPPIN NRRPTLLNGA LSTPTESPNT LVGLATREQL KSINVDKLNA
1260 1270
DEHTTLESFQ GTSPQDQGCL LLQA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JEP7 | A0A0G2JEP7_MOUSE | Enamelin | Enam | 1,349 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82698 mRNA Translation: AAB94312.1 |
CCDSi | CCDS19400.1 |
PIRi | T37193 |
RefSeqi | NP_059496.1, NM_017468.3 |
Genome annotation databases
Ensembli | ENSMUST00000031222; ENSMUSP00000031222; ENSMUSG00000029286 |
GeneIDi | 13801 |
KEGGi | mmu:13801 |
UCSCi | uc008xzt.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82698 mRNA Translation: AAB94312.1 |
CCDSi | CCDS19400.1 |
PIRi | T37193 |
RefSeqi | NP_059496.1, NM_017468.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 199447, 1 interactor |
STRINGi | 10090.ENSMUSP00000031222 |
PTM databases
GlyGeni | O55196, 6 sites |
iPTMneti | O55196 |
PhosphoSitePlusi | O55196 |
Proteomic databases
PaxDbi | O55196 |
PRIDEi | O55196 |
Protocols and materials databases
Antibodypediai | 24350, 79 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031222; ENSMUSP00000031222; ENSMUSG00000029286 |
GeneIDi | 13801 |
KEGGi | mmu:13801 |
UCSCi | uc008xzt.2, mouse |
Organism-specific databases
CTDi | 10117 |
MGIi | MGI:1333772, Enam |
Phylogenomic databases
eggNOGi | ENOG502R69E, Eukaryota |
GeneTreei | ENSGT00440000037826 |
HOGENOMi | CLU_280412_0_0_1 |
InParanoidi | O55196 |
OMAi | WNSWDHR |
OrthoDBi | 201332at2759 |
PhylomeDBi | O55196 |
TreeFami | TF337278 |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 13801, 0 hits in 17 CRISPR screens |
PROi | PR:O55196 |
RNActi | O55196, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029286, Expressed in molar tooth and 24 other tissues |
Genevisiblei | O55196, MM |
Family and domain databases
InterProi | View protein in InterPro IPR015673, Enamelin |
PANTHERi | PTHR16784, PTHR16784, 2 hits |
Pfami | View protein in Pfam PF15362, Enamelin, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENAM_MOUSE | |
Accessioni | O55196Primary (citable) accession number: O55196 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot