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Protein

Sodium-dependent noradrenaline transporter

Gene

Slc6a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.1 Publication

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi73Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi74Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi78Sodium 2By similarity1
Metal bindingi318Sodium 2By similarity1
Metal bindingi350Sodium 2By similarity1
Metal bindingi415Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi418Sodium 1By similarity1
Metal bindingi419Sodium 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • dopamine uptake involved in synaptic transmission Source: GO_Central
  • monoamine transport Source: MGI
  • neurotransmitter reuptake Source: SynGO
  • neurotransmitter transport Source: MGI
  • norepinephrine transport Source: MGI
  • response to pain Source: MGI

Keywordsi

Biological processNeurotransmitter transport, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name:
NET
Solute carrier family 6 member 2
Gene namesi
Name:Slc6a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1270850 Slc6a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicBy similarityAdd BLAST62
Transmembranei63 – 88Helical; Name=1By similarityAdd BLAST26
Topological domaini89 – 92ExtracellularBy similarity4
Transmembranei93 – 116Helical; Name=2By similarityAdd BLAST24
Topological domaini117 – 135CytoplasmicBy similarityAdd BLAST19
Transmembranei136 – 166Helical; Name=3By similarityAdd BLAST31
Topological domaini167 – 233ExtracellularBy similarityAdd BLAST67
Transmembranei234 – 254Helical; Name=4By similarityAdd BLAST21
Topological domaini255 – 257CytoplasmicBy similarity3
Transmembranei258 – 282Helical; Name=5By similarityAdd BLAST25
Topological domaini283 – 306ExtracellularBy similarityAdd BLAST24
Transmembranei307 – 332Helical; Name=6By similarityAdd BLAST26
Topological domaini333 – 338CytoplasmicBy similarity6
Transmembranei339 – 362Helical; Name=7By similarityAdd BLAST24
Topological domaini363 – 402ExtracellularBy similarityAdd BLAST40
Transmembranei403 – 428Helical; Name=8By similarityAdd BLAST26
Topological domaini429 – 443CytoplasmicBy similarityAdd BLAST15
Transmembranei444 – 464Helical; Name=9By similarityAdd BLAST21
Topological domaini465ExtracellularBy similarity1
Transmembranei466 – 492Helical; Name=10By similarityAdd BLAST27
Topological domaini493 – 522CytoplasmicBy similarityAdd BLAST30
Transmembranei523 – 545Helical; Name=11By similarityAdd BLAST23
Topological domaini546 – 548ExtracellularBy similarity3
Transmembranei549 – 569Helical; Name=12By similarityAdd BLAST21
Topological domaini570 – 617CytoplasmicBy similarityAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2370

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147491 – 617Sodium-dependent noradrenaline transporterAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi176 ↔ 185By similarity
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO55192
PaxDbiO55192
PeptideAtlasiO55192
PRIDEiO55192

PTM databases

iPTMnetiO55192
PhosphoSitePlusiO55192

Expressioni

Gene expression databases

BgeeiENSMUSG00000055368 Expressed in 219 organ(s), highest expression level in placenta
GenevisibleiO55192 MM

Interactioni

Subunit structurei

Interacts with PRKCABP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiO55192
STRINGi10090.ENSMUSP00000072709

Chemistry databases

BindingDBiO55192

Structurei

3D structure databases

ProteinModelPortaliO55192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiO55192
KOiK05035
OMAiAYCITPE
OrthoDBiEOG091G08PX
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002435 Na/ntran_symport_noradrenaline
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01201 NORTRANSPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

O55192-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLARMNPQV QPELGGADPL PEQPLRPCKT ADLLVVKERN GVQCLLASQD
60 70 80 90 100
SDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
110 120 130 140 150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF
160 170 180 190 200
YYNVIIAWSL YYLFASFTLN LPWTNCGHSW NSPNCTDPKL LNASVLGDHT
210 220 230 240 250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVIVVLYF
260 270 280 290 300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY
310 320 330 340 350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN
360 370 380 390 400
CVTSFISGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG
410 420 430 440 450
STFWAVLFFL MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTCVVT
460 470 480 490 500
ISTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR
510 520 530 540 550
FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYTY
560 570 580 590 600
PPWANWVGWG IALSSMILVP AYVIYKFLSI RGSLWERVAY GITPENEHHL
610
VAQRDVRQFQ LRHWLAI
Length:617
Mass (Da):69,255
Last modified:July 27, 2011 - v2
Checksum:i591641246B8DA59C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti609 – 612FQLR → LPLQ in AAB94302 (PubMed:9603188).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76306 mRNA Translation: AAB94302.1
AY525777 mRNA Translation: AAS17725.1
AY525778 mRNA Translation: AAS17726.1
CH466525 Genomic DNA Translation: EDL11093.1
CCDSiCCDS22525.1
RefSeqiNP_033235.3, NM_009209.3
UniGeneiMm.57040

Genome annotation databases

EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368
GeneIDi20538
KEGGimmu:20538
UCSCiuc009muh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76306 mRNA Translation: AAB94302.1
AY525777 mRNA Translation: AAS17725.1
AY525778 mRNA Translation: AAS17726.1
CH466525 Genomic DNA Translation: EDL11093.1
CCDSiCCDS22525.1
RefSeqiNP_033235.3, NM_009209.3
UniGeneiMm.57040

3D structure databases

ProteinModelPortaliO55192
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiO55192
STRINGi10090.ENSMUSP00000072709

Chemistry databases

BindingDBiO55192
ChEMBLiCHEMBL2370

PTM databases

iPTMnetiO55192
PhosphoSitePlusiO55192

Proteomic databases

MaxQBiO55192
PaxDbiO55192
PeptideAtlasiO55192
PRIDEiO55192

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368
GeneIDi20538
KEGGimmu:20538
UCSCiuc009muh.2 mouse

Organism-specific databases

CTDi6530
MGIiMGI:1270850 Slc6a2

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiO55192
KOiK05035
OMAiAYCITPE
OrthoDBiEOG091G08PX
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

Miscellaneous databases

ChiTaRSiSlc6a2 mouse
PROiPR:O55192
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055368 Expressed in 219 organ(s), highest expression level in placenta
GenevisibleiO55192 MM

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002435 Na/ntran_symport_noradrenaline
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01201 NORTRANSPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC6A2_MOUSE
AccessioniPrimary (citable) accession number: O55192
Secondary accession number(s): Q6QU62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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