Slc6a2

Functionⁱ

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.1 Publication

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	71	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	73	Sodium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	74	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	78	Sodium 2By similarity	1
Metal bindingⁱ	318	Sodium 2By similarity	1
Metal bindingⁱ	350	Sodium 2By similarity	1
Metal bindingⁱ	415	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	418	Sodium 1By similarity	1
Metal bindingⁱ	419	Sodium 1By similarity	1

GO - Molecular functionⁱ

actin binding Source: MGI
alpha-tubulin binding Source: MGI
beta-tubulin binding Source: MGI
dopamine:sodium symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
monoamine transmembrane transporter activity
Source: MGI
Inferred from sequence orthologyⁱ
- 16024787
neurotransmitter:sodium symporter activity Source: InterPro
norepinephrine:sodium symporter activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dopamine uptake involved in synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
monoamine transport
Source: MGI
Inferred from sequence orthologyⁱ
- 16024787
neurotransmitter reuptake
Source: SynGO
Inferred from mutant phenotypeⁱ
- 10769386
neurotransmitter transport
Source: MGI
Inferred from direct assayⁱ
- 11805341
norepinephrine transport Source: MGI
response to pain
Source: MGI
Inferred from mutant phenotypeⁱ
- 11805341

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurotransmitter transport, Symport, Transport
Ligand	Metal-binding, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

Reactomeⁱ

R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium-dependent noradrenaline transporter Alternative name(s): Norepinephrine transporter Short name: NET Solute carrier family 6 member 2
Gene namesⁱ	Name:Slc6a2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1270850 Slc6a2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 62	CytoplasmicBy similarityAdd BLAST	62
Transmembraneⁱ	63 – 88	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	89 – 92	ExtracellularBy similarity	4
Transmembraneⁱ	93 – 116	Helical; Name=2By similarityAdd BLAST	24
Topological domainⁱ	117 – 135	CytoplasmicBy similarityAdd BLAST	19
Transmembraneⁱ	136 – 166	Helical; Name=3By similarityAdd BLAST	31
Topological domainⁱ	167 – 233	ExtracellularBy similarityAdd BLAST	67
Transmembraneⁱ	234 – 254	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	255 – 257	CytoplasmicBy similarity	3
Transmembraneⁱ	258 – 282	Helical; Name=5By similarityAdd BLAST	25
Topological domainⁱ	283 – 306	ExtracellularBy similarityAdd BLAST	24
Transmembraneⁱ	307 – 332	Helical; Name=6By similarityAdd BLAST	26
Topological domainⁱ	333 – 338	CytoplasmicBy similarity	6
Transmembraneⁱ	339 – 362	Helical; Name=7By similarityAdd BLAST	24
Topological domainⁱ	363 – 402	ExtracellularBy similarityAdd BLAST	40
Transmembraneⁱ	403 – 428	Helical; Name=8By similarityAdd BLAST	26
Topological domainⁱ	429 – 443	CytoplasmicBy similarityAdd BLAST	15
Transmembraneⁱ	444 – 464	Helical; Name=9By similarityAdd BLAST	21
Topological domainⁱ	465	ExtracellularBy similarity	1
Transmembraneⁱ	466 – 492	Helical; Name=10By similarityAdd BLAST	27
Topological domainⁱ	493 – 522	CytoplasmicBy similarityAdd BLAST	30
Transmembraneⁱ	523 – 545	Helical; Name=11By similarityAdd BLAST	23
Topological domainⁱ	546 – 548	ExtracellularBy similarity	3
Transmembraneⁱ	549 – 569	Helical; Name=12By similarityAdd BLAST	21
Topological domainⁱ	570 – 617	CytoplasmicBy similarityAdd BLAST	48

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2370

ChEMBLⁱ

CHEMBL2370

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214749	1 – 617	Sodium-dependent noradrenaline transporterAdd BLAST		617

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	176 ↔ 185	By similarity
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	192	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O55192
PaxDbⁱ	O55192
PeptideAtlas More...PeptideAtlasⁱ	O55192
PRIDEⁱ	O55192

PTM databases

iPTMnetⁱ	O55192
PhosphoSitePlusⁱ	O55192

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000055368 Expressed in 219 organ(s), highest expression level in placenta
Genevisibleⁱ	O55192 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PRKCABP.By similarity

GO - Molecular functionⁱ

actin binding Source: MGI
alpha-tubulin binding Source: MGI
beta-tubulin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	O55192
STRINGⁱ	10090.ENSMUSP00000072709

Chemistry databases

BindingDBⁱ

O55192

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O55192
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	O55192
KEGG Orthology (KO) More...KOⁱ	K05035
OMAⁱ	AYCITPE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PX
TreeFamⁱ	TF343812

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002435 Na/ntran_symport_noradrenaline IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT PR01201 NORTRANSPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O55192-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLARMNPQV QPELGGADPL PEQPLRPCKT ADLLVVKERN GVQCLLASQD 
        60         70         80         90        100
SDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL 
       110        120        130        140        150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF 
       160        170        180        190        200
YYNVIIAWSL YYLFASFTLN LPWTNCGHSW NSPNCTDPKL LNASVLGDHT 
       210        220        230        240        250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVIVVLYF 
       260        270        280        290        300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 
       310        320        330        340        350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN 
       360        370        380        390        400
CVTSFISGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG 
       410        420        430        440        450
STFWAVLFFL MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTCVVT 
       460        470        480        490        500
ISTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR 
       510        520        530        540        550
FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYTY 
       560        570        580        590        600
PPWANWVGWG IALSSMILVP AYVIYKFLSI RGSLWERVAY GITPENEHHL 
       610 
VAQRDVRQFQ LRHWLAI

Length:617

Mass (Da):69,255

Last modified:July 27, 2011 - v2

Checksum:ⁱ591641246B8DA59C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	609 – 612	FQLR → LPLQ in AAB94302 (PubMed:9603188).Curated		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76306 mRNA Translation: AAB94302.1 AY525777 mRNA Translation: AAS17725.1 AY525778 mRNA Translation: AAS17726.1 CH466525 Genomic DNA Translation: EDL11093.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22525.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033235.3, NM_009209.3
UniGeneⁱ	Mm.57040

Genome annotation databases

Ensemblⁱ	ENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368 ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368
GeneIDⁱ	20538
KEGGⁱ	mmu:20538
UCSC genome browser More...UCSCⁱ	uc009muh.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O55192	Solute carrier family 6 member 2 (Fragment)		MOUSE		33	UniRef100_O55192
Norepinephrine transporter (Fragment)		MOUSE		18
UPI0003D73255		MOUSE		739

Protein	Similar proteins		Species	Score	Length	Source
O55192	Sodium-dependent noradrenaline transporter		HUMAN		617	UniRef90_P23975
Transporter		CRIGR		625
Transporter		HETGA		623
Solute carrier family 6 member 2 (Fragment)		MOUSE		33
Transporter		PONAB		617
+62

Protein	Similar proteins		Species	Score	Length	Source
O55192	Sodium-dependent dopamine transporter		HUMAN		620	UniRef50_Q01959
Sodium-dependent dopamine transporter		MACFA		620
Sodium-dependent dopamine transporter		RAT		619
Sodium-dependent dopamine transporter		MOUSE		619
Sodium-dependent noradrenaline transporter		BOVIN		615
+241

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76306 mRNA Translation: AAB94302.1 AY525777 mRNA Translation: AAS17725.1 AY525778 mRNA Translation: AAS17726.1 CH466525 Genomic DNA Translation: EDL11093.1
CCDSⁱ	CCDS22525.1
RefSeqⁱ	NP_033235.3, NM_009209.3
UniGeneⁱ	Mm.57040

3D structure databases

ProteinModelPortalⁱ	O55192
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

MINTⁱ	O55192
STRINGⁱ	10090.ENSMUSP00000072709

Chemistry databases

BindingDBⁱ	O55192
ChEMBLⁱ	CHEMBL2370

PTM databases

iPTMnetⁱ	O55192
PhosphoSitePlusⁱ	O55192

Proteomic databases

MaxQBⁱ	O55192
PaxDbⁱ	O55192
PeptideAtlasⁱ	O55192
PRIDEⁱ	O55192

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368 ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368
GeneIDⁱ	20538
KEGGⁱ	mmu:20538
UCSCⁱ	uc009muh.2 mouse

Organism-specific databases

CTDⁱ	6530
MGIⁱ	MGI:1270850 Slc6a2

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	O55192
KOⁱ	K05035
OMAⁱ	AYCITPE
OrthoDBⁱ	EOG091G08PX
TreeFamⁱ	TF343812

Enzyme and pathway databases

Reactomeⁱ	R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

Reactomeⁱ

R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

Miscellaneous databases

ChiTaRSⁱ	Slc6a2 mouse
Protein Ontology More...PROⁱ	PR:O55192
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000055368 Expressed in 219 organ(s), highest expression level in placenta
Genevisibleⁱ	O55192 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002435 Na/ntran_symport_noradrenaline IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT PR01201 NORTRANSPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SC6A2_MOUSE
Accessionⁱ	O55192Primary (citable) accession number: O55192 Secondary accession number(s): Q6QU62
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O55192 (SC6A2_MOUSE)

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Sodium-dependent noradrenaline transporter

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ