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Protein

Dentin matrix acidic phosphoprotein 1

Gene

Dmp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).By similarity

GO - Molecular functioni

  • extracellular matrix binding Source: MGI
  • Hsp70 protein binding Source: MGI

GO - Biological processi

Keywordsi

Biological processBiomineralization

Enzyme and pathway databases

ReactomeiR-MMU-3000178 ECM proteoglycans
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Dentin matrix acidic phosphoprotein 1
Short name:
DMP-1
Short name:
Dentin matrix protein 1
Alternative name(s):
AG1
Gene namesi
Name:Dmp1
Synonyms:Dmp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:94910 Dmp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Nucleus, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display rickets and osteomalacia with isolated renal phosphate wasting associated with elevated FGF23 levels and normocalciuria.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002111117 – 503Dentin matrix acidic phosphoprotein 1Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO55188
PeptideAtlasiO55188
PRIDEiO55188

PTM databases

iPTMnetiO55188
PhosphoSitePlusiO55188

Expressioni

Tissue specificityi

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast. Also expressed in bone particularly in osteoblast.

Gene expression databases

BgeeiENSMUSG00000029307 Expressed in 118 organ(s), highest expression level in cochlea
CleanExiMM_DMP1
GenevisibleiO55188 MM

Interactioni

Subunit structurei

Interacts with importin alpha.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068053

Structurei

3D structure databases

ProteinModelPortaliO55188
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi350 – 352Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 44Poly-Pro4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1181 Eukaryota
ENOG4111M3T LUCA
GeneTreeiENSGT00730000111375
HOGENOMiHOG000220909
HOVERGENiHBG073257
InParanoidiO55188
OMAiHGDGSEF
OrthoDBiEOG091G0U5E
TreeFamiTF337029

Family and domain databases

InterProiView protein in InterPro
IPR009889 DMP1
PANTHERiPTHR23400 PTHR23400, 1 hit
PfamiView protein in Pfam
PF07263 DMP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55188-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTVILLVFL WGLSCALPVA RYHNTESESS EERTGDLAGS PPPPTNSESS
60 70 80 90 100
EESQASPEGQ ANSDHTDSSE SGEELGYDRG QYRPAGGLSK STGTGADKED
110 120 130 140 150
DEDDSGDDTF GDEDNDLGPE EGQWGGPSKL DSDEDSTDTT QSSEDSTSQE
160 170 180 190 200
NSAQDTPSDS KDHDSEDEAD SRPEAGDSTQ DSESEEQRVG GGSEGESSHG
210 220 230 240 250
DGSEFDDEGM QSDDPESTRS DRGHARMSSA GIRSEESKGD HEPTSTQDSD
260 270 280 290 300
DSQSVEFSSR KSFRRSHVSE EDYRGELTDS NSRETQSDST EDTASKEESR
310 320 330 340 350
SESQEDTAES QSQEDSPEGQ DPSSESSEEA GEPSQESSSE SQEGVTSESR
360 370 380 390 400
GDNPDNTSQA GDQEDSESSE EDSLNTFSSS ESQSTEEQAD SESNESLSLS
410 420 430 440 450
EESQESAQDG DSSSQEGLQS QSASTESRSQ ESQSEQDSRS EEDSDSQDSS
460 470 480 490 500
RSKEESNSTG SASSSEEDIR PKNMEADSRK LIVDAYHNKP IGDQDDNDCQ

DGY
Length:503
Mass (Da):53,965
Last modified:July 27, 2011 - v2
Checksum:iA8FA932A126F8541
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35G → D in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti59G → A in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti59G → A in CAB59629 (Ref. 2) Curated1
Sequence conflicti67D → H in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti67D → H in CAB59629 (Ref. 2) Curated1
Sequence conflicti99E → D in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti99E → D in CAB59629 (Ref. 2) Curated1
Sequence conflicti116D → G in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti116D → Y in CAB59629 (Ref. 2) Curated1
Sequence conflicti137T → A in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti137T → A in CAB59629 (Ref. 2) Curated1
Sequence conflicti163H → Q in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti163H → Q in CAB59629 (Ref. 2) Curated1
Sequence conflicti168 – 170EAD → DAH in AAB93764 (PubMed:9525343).Curated3
Sequence conflicti168 – 170EAD → DAH in CAB59629 (Ref. 2) Curated3
Sequence conflicti174E → D in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti174E → D in CAB59629 (Ref. 2) Curated1
Sequence conflicti179 – 181TQD → AQH in AAB93764 (PubMed:9525343).Curated3
Sequence conflicti179 – 181TQD → AQH in CAB59629 (Ref. 2) Curated3
Sequence conflicti196E → Q in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti196E → Q in CAB59629 (Ref. 2) Curated1
Sequence conflicti241H → R in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti241H → R in CAB59629 (Ref. 2) Curated1
Sequence conflicti267H → R in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti267H → R in CAB59629 (Ref. 2) Curated1
Sequence conflicti360A → T in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti360A → T in CAB59629 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65020 mRNA Translation: AAB93764.1
AJ242625 Genomic DNA Translation: CAB59629.1
AK132177 mRNA Translation: BAE21014.1
AK157973 mRNA Translation: BAE34293.1
CH466529 Genomic DNA Translation: EDL20228.1
CCDSiCCDS19484.1
RefSeqiNP_058059.2, NM_016779.2
XP_006534829.1, XM_006534766.2
UniGeneiMm.199008

Genome annotation databases

EnsembliENSMUST00000066708; ENSMUSP00000068053; ENSMUSG00000029307
GeneIDi13406
KEGGimmu:13406
UCSCiuc008yke.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65020 mRNA Translation: AAB93764.1
AJ242625 Genomic DNA Translation: CAB59629.1
AK132177 mRNA Translation: BAE21014.1
AK157973 mRNA Translation: BAE34293.1
CH466529 Genomic DNA Translation: EDL20228.1
CCDSiCCDS19484.1
RefSeqiNP_058059.2, NM_016779.2
XP_006534829.1, XM_006534766.2
UniGeneiMm.199008

3D structure databases

ProteinModelPortaliO55188
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068053

PTM databases

iPTMnetiO55188
PhosphoSitePlusiO55188

Proteomic databases

PaxDbiO55188
PeptideAtlasiO55188
PRIDEiO55188

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066708; ENSMUSP00000068053; ENSMUSG00000029307
GeneIDi13406
KEGGimmu:13406
UCSCiuc008yke.1 mouse

Organism-specific databases

CTDi1758
MGIiMGI:94910 Dmp1

Phylogenomic databases

eggNOGiKOG1181 Eukaryota
ENOG4111M3T LUCA
GeneTreeiENSGT00730000111375
HOGENOMiHOG000220909
HOVERGENiHBG073257
InParanoidiO55188
OMAiHGDGSEF
OrthoDBiEOG091G0U5E
TreeFamiTF337029

Enzyme and pathway databases

ReactomeiR-MMU-3000178 ECM proteoglycans
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:O55188
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029307 Expressed in 118 organ(s), highest expression level in cochlea
CleanExiMM_DMP1
GenevisibleiO55188 MM

Family and domain databases

InterProiView protein in InterPro
IPR009889 DMP1
PANTHERiPTHR23400 PTHR23400, 1 hit
PfamiView protein in Pfam
PF07263 DMP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDMP1_MOUSE
AccessioniPrimary (citable) accession number: O55188
Secondary accession number(s): Q3TZB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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