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Protein

Stanniocalcin-1

Gene

Stc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.By similarity

GO - Molecular functioni

  • hormone activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-1
Short name:
STC-1
Gene namesi
Name:Stc1
Synonyms:Stc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109131 Stc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000003329919 – 33Sequence analysisAdd BLAST15
ChainiPRO_000003330034 – 247Stanniocalcin-1Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 59By similarity
Disulfide bondi54 ↔ 74By similarity
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi65 ↔ 114By similarity
Disulfide bondi98 ↔ 128By similarity
Disulfide bondi135 ↔ 170By similarity
Disulfide bondi202InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55183
PRIDEiO55183

PTM databases

iPTMnetiO55183
PhosphoSitePlusiO55183

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

BgeeiENSMUSG00000014813 Expressed in 198 organ(s), highest expression level in head mesenchyme
CleanExiMM_STC1
ExpressionAtlasiO55183 baseline and differential
GenevisibleiO55183 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014957

Structurei

3D structure databases

ProteinModelPortaliO55183
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH10 Eukaryota
ENOG410YPCI LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000008670
HOVERGENiHBG003575
InParanoidiO55183
OMAiCSVAKRN
OrthoDBiEOG091G0HC1
PhylomeDBiO55183
TreeFamiTF324693

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55183-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQNSAVILA LVISAAAAHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL
60 70 80 90 100
QVGCGAFACL ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA
110 120 130 140 150
NGITSKVFLA IRRCSTFQRM IAEVQEDCYS KLNVCSIAKR NPEAITEVIQ
160 170 180 190 200
LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD SLMEKIGPNM ASLFHILQTD
210 220 230 240
HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEGDSPSHIK RTSQESA
Length:247
Mass (Da):27,480
Last modified:June 1, 1998 - v1
Checksum:iDAD30D08575A513B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47815 Genomic DNA Translation: AAC00050.1
BC021425 mRNA Translation: AAH21425.1
CCDSiCCDS27236.1
RefSeqiNP_033311.3, NM_009285.3
UniGeneiMm.20911

Genome annotation databases

EnsembliENSMUST00000014957; ENSMUSP00000014957; ENSMUSG00000014813
GeneIDi20855
KEGGimmu:20855
UCSCiuc007ulz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47815 Genomic DNA Translation: AAC00050.1
BC021425 mRNA Translation: AAH21425.1
CCDSiCCDS27236.1
RefSeqiNP_033311.3, NM_009285.3
UniGeneiMm.20911

3D structure databases

ProteinModelPortaliO55183
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014957

PTM databases

iPTMnetiO55183
PhosphoSitePlusiO55183

Proteomic databases

PaxDbiO55183
PRIDEiO55183

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014957; ENSMUSP00000014957; ENSMUSG00000014813
GeneIDi20855
KEGGimmu:20855
UCSCiuc007ulz.1 mouse

Organism-specific databases

CTDi6781
MGIiMGI:109131 Stc1

Phylogenomic databases

eggNOGiENOG410IH10 Eukaryota
ENOG410YPCI LUCA
GeneTreeiENSGT00390000005989
HOGENOMiHOG000008670
HOVERGENiHBG003575
InParanoidiO55183
OMAiCSVAKRN
OrthoDBiEOG091G0HC1
PhylomeDBiO55183
TreeFamiTF324693

Miscellaneous databases

PROiPR:O55183
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014813 Expressed in 198 organ(s), highest expression level in head mesenchyme
CleanExiMM_STC1
ExpressionAtlasiO55183 baseline and differential
GenevisibleiO55183 MM

Family and domain databases

InterProiView protein in InterPro
IPR004978 Stanniocalcin
PANTHERiPTHR11245 PTHR11245, 1 hit
PfamiView protein in Pfam
PF03298 Stanniocalcin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTC1_MOUSE
AccessioniPrimary (citable) accession number: O55183
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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