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Entry version 152 (02 Jun 2021)
Sequence version 1 (01 Jun 1998)
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Protein

Multiple PDZ domain protein

Gene

Mpdz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:15312654).

Promotes clustering of HT2RC at the cell surface (PubMed:11150294).

2 Publications

Miscellaneous

Sequestered into cytoplasmic, detergent-resistant bodies upon Ad9 E4-ORF1 oncoprotein expression. Targeted to degradation upon HPV-18 E6 oncoprotein expression.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • intracellular signal transduction Source: RGD
  • myelination Source: RGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple PDZ domain protein
Alternative name(s):
Multi-PDZ domain protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mpdz
Synonyms:Mupp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
3105, Mpdz

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945961 – 2054Multiple PDZ domain proteinAdd BLAST2054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphoserineBy similarity1
Modified residuei782PhosphoserineBy similarity1
Modified residuei1065PhosphoserineBy similarity1
Modified residuei1157Omega-N-methylarginineBy similarity1
Modified residuei1802PhosphoserineBy similarity1
Modified residuei1808PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O55164

PRoteomics IDEntifications database

More...
PRIDEi
O55164

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O55164

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O55164

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in all cerebral cortical layers, especially the piriform cortex, the pyramidal cells of the CA1-CA3 subfields of the hippocampus, as well as the granular layer of the dentate gyrus. Detected in the internal granular layer and the mitral cell layer of the olfactory bulb; in the medial habenular nucleus; and in amygdaloid, thalamic, hypothalamic, and pontine nuclei. In the cerebellum, found at high levels in the granular layer. Detected in the lateral ventricle. Expression overlaps with 5-HT2C receptor expression in all regions of the brain including the choroid plexus, where 5-HT2C receptors are highly enriched.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007894, Expressed in quadriceps femoris and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O55164, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O55164, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and PALS1, HTR2A, HTR2B, PLEKHA1/TAPP1 and PLEKHA2/TAPP2.

Interacts with CXADR (By similarity).

Interacts with HTR2C, CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B.

Interacts with FAT4 (via cytoplasmic domain) (By similarity).

Interacts with DLL1 (By similarity).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
248019, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O55164

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
O55164

Protein interaction database and analysis system

More...
IntActi
O55164, 1 interactor

Molecular INTeraction database

More...
MINTi
O55164

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000051321

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12054
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O55164

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O55164

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 63L27PROSITE-ProRule annotationAdd BLAST61
Domaini138 – 225PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini258 – 338PDZ 2PROSITE-ProRule annotationAdd BLAST81
Domaini377 – 463PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini545 – 626PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini692 – 778PDZ 5PROSITE-ProRule annotationAdd BLAST87
Domaini995 – 1076PDZ 6PROSITE-ProRule annotationAdd BLAST82
Domaini1138 – 1230PDZ 7PROSITE-ProRule annotationAdd BLAST93
Domaini1337 – 1420PDZ 8PROSITE-ProRule annotationAdd BLAST84
Domaini1470 – 1551PDZ 9PROSITE-ProRule annotationAdd BLAST82
Domaini1613 – 1696PDZ 10PROSITE-ProRule annotationAdd BLAST84
Domaini1709 – 1791PDZ 11PROSITE-ProRule annotationAdd BLAST83
Domaini1846 – 1932PDZ 12PROSITE-ProRule annotationAdd BLAST87
Domaini1971 – 2054PDZ 13PROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1110 – 1129DisorderedSequence analysisAdd BLAST20
Regioni1261 – 1312DisorderedSequence analysisAdd BLAST52
Regioni1433 – 1454DisorderedSequence analysisAdd BLAST22
Regioni1560 – 1594DisorderedSequence analysisAdd BLAST35
Regioni1795 – 1834DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1261 – 1304Polar residuesSequence analysisAdd BLAST44
Compositional biasi1436 – 1454Polar residuesSequence analysisAdd BLAST19
Compositional biasi1798 – 1834Polar residuesSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain 1 binds NG2. The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds CXADR and SYNGAP1 (By similarity). The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C.By similarity2 Publications

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3528, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002378_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O55164

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O55164

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 13 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015132, L27_2
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR032078, MPDZ
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09045, L27_2, 1 hit
PF16667, MPDZ_u10, 1 hit
PF00595, PDZ, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00569, L27, 1 hit
SM00228, PDZ, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101288, SSF101288, 1 hit
SSF50156, SSF50156, 13 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51022, L27, 1 hit
PS50106, PDZ, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O55164-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLETIDKNRA LQAAERLQSK LKERGDVANE DKLSLLKSVL QSPLFSQILS
60 70 80 90 100
LQTSLQQLKD QVNVATLATA NADHAHTPQF SSAIISNLQS ESLLLSPSNG
110 120 130 140 150
NLEAISGPGA PPAMDGKPAC EELDQLIKSM AQGRHVEIFE LLKPPCGGLG
160 170 180 190 200
FSVVGLRSEN RGELGIFVQE IQEGSVAHRD GRLKETDQIL AINGQVLDQT
210 220 230 240 250
ITHQQAISIL QKAKDTIQLV IARGSLPHIS SPRISRSPSA ASTVSAHSNP
260 270 280 290 300
THWQHVETIE LVNDGSGLGF GIIGGKATGV IVKTILPGGV ADQHGRLCSG
310 320 330 340 350
DHILKIGDTD LAGMSSEQVA QVLRQCGNRV KLMIARGAVE ETPAPSSLGI
360 370 380 390 400
TLSSSTSTSE MRVDASTQKN EESETFDVEL TKNVQGLGIT IAGYIGDKKL
410 420 430 440 450
EPSGIFVKSI TKSSAVELDG RIQIGDQIVA VDGTNLQGFT NQQAVEVLRH
460 470 480 490 500
TGQTVRLTLM RKGASQEAEI TSREDTAKDV DLPAENYEKD EESLSLKRST
510 520 530 540 550
SILPIEEEGY PLLSTELEET EDVQQEAALL TKWQRIMGIN YEIVVAHVSK
560 570 580 590 600
FSENSGLGIS LEATVGHHFI RSVLPEGPVG HSGKLFSGDE LLEVNGINLL
610 620 630 640 650
GENHQDVVNI LKELPIDVTM VCCRRTVPPT ALSEVDSLDI HDLELTEKPH
660 670 680 690 700
IDLGEFIGSS ETEDPMLAMS DVDQNAEEIQ TPLAMWEAGI QAIELEKGSR
710 720 730 740 750
GLGFSILDYQ DPIDPANTVI VIRSLVPGGI AEKDGRLFPG DRLMFVNDIN
760 770 780 790 800
LENSTLEEAV EALKGAPSGM VRIGVAKPLP LSPEEGYVSA KEDTFLCSPH
810 820 830 840 850
TCKEMGLSDK ALFRADLALI DTPDAESVAE SRFESQFSPD NDSVYSTQAS
860 870 880 890 900
VLSLHDGACS DGMNYGPSLP SSPPKDVTNS SDLVLGLHLS LEELYTQNLL
910 920 930 940 950
QRQHAGSPPT DMSPAATSGF TVSDYTPANA VEQKYECANT VAWTPSQLPS
960 970 980 990 1000
GLSTTELAPA LPAVAPKYLT EQSSLVSDAE SVTLQSMSQE AFERTVTIAK
1010 1020 1030 1040 1050
GSSSLGMTVS ANKDGLGVIV RSIIHGGAIS RDGRIAVGDC ILSINEESTI
1060 1070 1080 1090 1100
SLTNAQARAM LRRHSLIGPD IKITYVPAEH LEEFRVSFGQ QAGGIMALDI
1110 1120 1130 1140 1150
FSSYTGRDIP ELPEREEGEG EESELQNAAY SSWSQPRRVE LWREPSKSLG
1160 1170 1180 1190 1200
ISIVGGRGMG SRLSNGEVMR GIFIKHVLED SPAGKNGTLK PGDRIVEVDG
1210 1220 1230 1240 1250
MDLRDASHEQ AVEAIRKAGS PVVFMVQSIV NRPRKSPLPS LPHSLYPKCS
1260 1270 1280 1290 1300
FSSTNPFAES LQLTSDKAPS QSESESEKAT LCSVPSSSPS VFSEMSSDYA
1310 1320 1330 1340 1350
QPSATTVAED EDKEDEFGYS WKNIQERYGT LTGQLHMIEL EKGHSGLGLS
1360 1370 1380 1390 1400
LAGNKDRTRM SVFIVGIDPT GAAGRDGRLQ IADELLEING QILYGRSHQN
1410 1420 1430 1440 1450
ASSIIKCAPS KVKIIFIRNA DAVNQMAVCP GSAADPLPST SESPQNKEVE
1460 1470 1480 1490 1500
PSITTSASAV DLSSLTNVYH LELPKDQGGL GIAICEEDTL NGVTIKSLTE
1510 1520 1530 1540 1550
RGGAAKDGRL KPGDRILAVD DELVAGCPIE KFISLLKTAK TTVKLTVGAE
1560 1570 1580 1590 1600
NPGCQAVPSA AVTASGERKD SSQTPAVPAP DLEPIPSTSR SSTPAIFASD
1610 1620 1630 1640 1650
PATCPIIPGC ETTIEISKGQ TGLGLSIVGG SDTLLGAIII HEVYEEGAAC
1660 1670 1680 1690 1700
KDGRLWAGDQ ILEVNGIDLR KATHDEAINV LRQTPQRVRL TLYRDEAPYK
1710 1720 1730 1740 1750
EEDVCDTFTV ELQKRPGKGL GLSIVGKRND TGVFVSDIVK GGIADADGRL
1760 1770 1780 1790 1800
MQGDQILMVN GEDVRNATQE AVAALLKCSL GTVTLEVGRI KAAPFHSERR
1810 1820 1830 1840 1850
PSQSSQVSES SLSSFSLPRS GIHTSESSES SAKKNALASE IQGLRTVEIK
1860 1870 1880 1890 1900
KGPADALGLS IAGGVGSPLG DVPIFIAMMH PNGVAAQTQK LRVGDRIVTI
1910 1920 1930 1940 1950
CGTSTDGMTH TQAVNLMKNA SGSIEVQVVA GGDVSVVTGH QQELANPCLA
1960 1970 1980 1990 2000
FTGLTSSTIF PDDLGPPQSK TITLDRGPDG LGFSIVGGYG SPHGDLPIYV
2010 2020 2030 2040 2050
KTVFAKGAAA EDGRLKRGDQ IIAVNGQSLE GVTHEEAVAI LKRTKGTVTL

MVLS
Length:2,054
Mass (Da):218,592
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44BD3F42B801F78F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K2Y8A0A0G2K2Y8_RAT
Multiple PDZ domain protein
Mpdz
2,068Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ001320 mRNA Translation: CAA04681.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46612

NCBI Reference Sequences

More...
RefSeqi
NP_062069.1, NM_019196.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000051028; ENSRNOP00000051321; ENSRNOG00000007894

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29365

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:29365

UCSC genome browser

More...
UCSCi
RGD:3105, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001320 mRNA Translation: CAA04681.1
PIRiT46612
RefSeqiNP_062069.1, NM_019196.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y76NMR-A/C4-65[»]
5DTHX-ray1.95A/B/C/D1312-1422[»]
SMRiO55164
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi248019, 6 interactors
CORUMiO55164
ELMiO55164
IntActiO55164, 1 interactor
MINTiO55164
STRINGi10116.ENSRNOP00000051321

PTM databases

iPTMnetiO55164
PhosphoSitePlusiO55164

Proteomic databases

PaxDbiO55164
PRIDEiO55164

Genome annotation databases

EnsembliENSRNOT00000051028; ENSRNOP00000051321; ENSRNOG00000007894
GeneIDi29365
KEGGirno:29365
UCSCiRGD:3105, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8777
RGDi3105, Mpdz

Phylogenomic databases

eggNOGiKOG3528, Eukaryota
GeneTreeiENSGT00940000155586
HOGENOMiCLU_002378_0_0_1
InParanoidiO55164
PhylomeDBiO55164

Miscellaneous databases

EvolutionaryTraceiO55164

Protein Ontology

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PROi
PR:O55164

Gene expression databases

BgeeiENSRNOG00000007894, Expressed in quadriceps femoris and 20 other tissues
ExpressionAtlasiO55164, baseline and differential
GenevisibleiO55164, RN

Family and domain databases

Gene3Di2.30.42.10, 13 hits
InterProiView protein in InterPro
IPR015132, L27_2
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR032078, MPDZ
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF09045, L27_2, 1 hit
PF16667, MPDZ_u10, 1 hit
PF00595, PDZ, 13 hits
SMARTiView protein in SMART
SM00569, L27, 1 hit
SM00228, PDZ, 13 hits
SUPFAMiSSF101288, SSF101288, 1 hit
SSF50156, SSF50156, 13 hits
PROSITEiView protein in PROSITE
PS51022, L27, 1 hit
PS50106, PDZ, 13 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPDZ_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O55164
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 1998
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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