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Protein

T-cell leukemia homeobox protein 3

Gene

Tlx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi166 – 225HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 3
Alternative name(s):
Homeobox TLX-3
Homeobox protein Hox-11L2
Respiratory neuron homeobox protein
Gene namesi
Name:Tlx3
Synonyms:Hox11l2, Rnx, Tlx1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1351209 Tlx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493391 – 291T-cell leukemia homeobox protein 3Add BLAST291

Proteomic databases

PaxDbiO55144
PRIDEiO55144

PTM databases

iPTMnetiO55144
PhosphoSitePlusiO55144

Expressioni

Gene expression databases

BgeeiENSMUSG00000040610 Expressed in 54 organ(s), highest expression level in head
CleanExiMM_TLX3
GenevisibleiO55144 MM

Interactioni

Protein-protein interaction databases

BioGridi205124, 34 interactors
STRINGi10090.ENSMUSP00000047457

Structurei

3D structure databases

ProteinModelPortaliO55144
SMRiO55144
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000116280
HOVERGENiHBG036206
InParanoidiO55144
KOiK15607
OMAiYNPACSM
OrthoDBiEOG091G0RNV
TreeFamiTF325347

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O55144-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG
60 70 80 90 100
RPGAAYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV
110 120 130 140 150
PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV
160 170 180 190 200
TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA
210 220 230 240 250
KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK
260 270 280 290
SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
Length:291
Mass (Da):31,837
Last modified:October 16, 2013 - v2
Checksum:iA0E3B9103D2FA5E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232 – 233ER → DG in CAA11551 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223801 mRNA Translation: CAA11551.1
AK141870 mRNA Translation: BAE24864.1
AL772409 Genomic DNA No translation available.
CH466604 Genomic DNA Translation: EDL23743.1
BC141308 mRNA Translation: AAI41309.1
BC145631 mRNA Translation: AAI45632.1
CCDSiCCDS24533.1
RefSeqiNP_064300.2, NM_019916.2
UniGeneiMm.25362

Genome annotation databases

EnsembliENSMUST00000037746; ENSMUSP00000047457; ENSMUSG00000040610
GeneIDi27140
KEGGimmu:27140
UCSCiuc007ikg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223801 mRNA Translation: CAA11551.1
AK141870 mRNA Translation: BAE24864.1
AL772409 Genomic DNA No translation available.
CH466604 Genomic DNA Translation: EDL23743.1
BC141308 mRNA Translation: AAI41309.1
BC145631 mRNA Translation: AAI45632.1
CCDSiCCDS24533.1
RefSeqiNP_064300.2, NM_019916.2
UniGeneiMm.25362

3D structure databases

ProteinModelPortaliO55144
SMRiO55144
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205124, 34 interactors
STRINGi10090.ENSMUSP00000047457

PTM databases

iPTMnetiO55144
PhosphoSitePlusiO55144

Proteomic databases

PaxDbiO55144
PRIDEiO55144

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037746; ENSMUSP00000047457; ENSMUSG00000040610
GeneIDi27140
KEGGimmu:27140
UCSCiuc007ikg.2 mouse

Organism-specific databases

CTDi30012
MGIiMGI:1351209 Tlx3

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000116280
HOVERGENiHBG036206
InParanoidiO55144
KOiK15607
OMAiYNPACSM
OrthoDBiEOG091G0RNV
TreeFamiTF325347

Miscellaneous databases

PROiPR:O55144
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040610 Expressed in 54 organ(s), highest expression level in head
CleanExiMM_TLX3
GenevisibleiO55144 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLX3_MOUSE
AccessioniPrimary (citable) accession number: O55144
Secondary accession number(s): Q5SQB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 16, 2013
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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