Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L35a

Gene

Rpl35a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.By similarity

GO - Molecular functioni

  • ribonucleoprotein complex binding Source: MGI
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L35a
Gene namesi
Name:Rpl35a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1928894 Rpl35a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001927981 – 11060S ribosomal protein L35aAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei63N6-acetyllysine; alternateCombined sources1
Modified residuei63N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO55142
PaxDbiO55142
PeptideAtlasiO55142
PRIDEiO55142
TopDownProteomicsiO55142

PTM databases

iPTMnetiO55142
PhosphoSitePlusiO55142
SwissPalmiO55142

Expressioni

Gene expression databases

BgeeiENSMUSG00000060636 Expressed in 33 organ(s), highest expression level in thymus
CleanExiMM_RPL35A
ExpressionAtlasiO55142 baseline and differential
GenevisibleiO55142 MM

Interactioni

Protein-protein interaction databases

BioGridi208332, 3 interactors
IntActiO55142, 2 interactors
MINTiO55142
STRINGi10090.ENSMUSP00000077857

Structurei

3D structure databases

ProteinModelPortaliO55142
SMRiO55142
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0887 Eukaryota
COG2451 LUCA
GeneTreeiENSGT00390000016972
HOGENOMiHOG000195636
HOVERGENiHBG054581
InParanoidiO55142
KOiK02917
OMAiSTRLYSK
OrthoDBiEOG091G112U
PhylomeDBiO55142
TreeFamiTF300104

Family and domain databases

Gene3Di2.40.10.190, 1 hit
HAMAPiMF_00573 Ribosomal_L35Ae, 1 hit
InterProiView protein in InterPro
IPR038661 L35A_sf
IPR001780 Ribosomal_L35A
IPR018266 Ribosomal_L35Ae_CS
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR10902 PTHR10902, 1 hit
PfamiView protein in Pfam
PF01247 Ribosomal_L35Ae, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012670 Ribosomal_L35Ae, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
PROSITEiView protein in PROSITE
PS01105 RIBOSOMAL_L35AE, 1 hit

Sequencei

Sequence statusi: Complete.

O55142-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRLWCKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV
60 70 80 90 100
YKAKNNTVTP GGKPNKTRVI WGKVTRAHGN SGMVRAKFRS NLPAKAIGHR
110
IRVMLYPSRI
Length:110
Mass (Da):12,554
Last modified:March 29, 2004 - v2
Checksum:i126B5E77E75F29F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16430 mRNA Translation: CAA76215.2
AK028214 mRNA Translation: BAC25818.1
CCDSiCCDS28126.1
RefSeqiNP_001123956.1, NM_001130484.1
NP_001123957.1, NM_001130485.1
NP_067313.2, NM_021338.3
UniGeneiMm.19355

Genome annotation databases

EnsembliENSMUST00000078804; ENSMUSP00000077857; ENSMUSG00000060636
ENSMUST00000115075; ENSMUSP00000110727; ENSMUSG00000060636
ENSMUST00000115076; ENSMUSP00000110728; ENSMUSG00000060636
ENSMUST00000115078; ENSMUSP00000110730; ENSMUSG00000060636
ENSMUST00000115079; ENSMUSP00000110731; ENSMUSG00000060636
GeneIDi57808
KEGGimmu:57808
UCSCiuc007yzu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16430 mRNA Translation: CAA76215.2
AK028214 mRNA Translation: BAC25818.1
CCDSiCCDS28126.1
RefSeqiNP_001123956.1, NM_001130484.1
NP_001123957.1, NM_001130485.1
NP_067313.2, NM_021338.3
UniGeneiMm.19355

3D structure databases

ProteinModelPortaliO55142
SMRiO55142
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208332, 3 interactors
IntActiO55142, 2 interactors
MINTiO55142
STRINGi10090.ENSMUSP00000077857

PTM databases

iPTMnetiO55142
PhosphoSitePlusiO55142
SwissPalmiO55142

Proteomic databases

EPDiO55142
PaxDbiO55142
PeptideAtlasiO55142
PRIDEiO55142
TopDownProteomicsiO55142

Protocols and materials databases

DNASUi100505110
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078804; ENSMUSP00000077857; ENSMUSG00000060636
ENSMUST00000115075; ENSMUSP00000110727; ENSMUSG00000060636
ENSMUST00000115076; ENSMUSP00000110728; ENSMUSG00000060636
ENSMUST00000115078; ENSMUSP00000110730; ENSMUSG00000060636
ENSMUST00000115079; ENSMUSP00000110731; ENSMUSG00000060636
GeneIDi57808
KEGGimmu:57808
UCSCiuc007yzu.2 mouse

Organism-specific databases

CTDi6165
MGIiMGI:1928894 Rpl35a

Phylogenomic databases

eggNOGiKOG0887 Eukaryota
COG2451 LUCA
GeneTreeiENSGT00390000016972
HOGENOMiHOG000195636
HOVERGENiHBG054581
InParanoidiO55142
KOiK02917
OMAiSTRLYSK
OrthoDBiEOG091G112U
PhylomeDBiO55142
TreeFamiTF300104

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

PROiPR:O55142
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060636 Expressed in 33 organ(s), highest expression level in thymus
CleanExiMM_RPL35A
ExpressionAtlasiO55142 baseline and differential
GenevisibleiO55142 MM

Family and domain databases

Gene3Di2.40.10.190, 1 hit
HAMAPiMF_00573 Ribosomal_L35Ae, 1 hit
InterProiView protein in InterPro
IPR038661 L35A_sf
IPR001780 Ribosomal_L35A
IPR018266 Ribosomal_L35Ae_CS
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR10902 PTHR10902, 1 hit
PfamiView protein in Pfam
PF01247 Ribosomal_L35Ae, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012670 Ribosomal_L35Ae, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
PROSITEiView protein in PROSITE
PS01105 RIBOSOMAL_L35AE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL35A_MOUSE
AccessioniPrimary (citable) accession number: O55142
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 29, 2004
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again