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Protein

Septin-7

Gene

Sept7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity).By similarity

Miscellaneous

Coordinated expression with SEPT2 and SEPT6.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89GTPBy similarity1
Binding sitei115GTP; via amide nitrogenBy similarity1
Binding sitei249GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei264GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 63GTPBy similarity8
Nucleotide bindingi194 – 202GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: MGI
  • protein-containing complex scaffold activity Source: GO_Central
  • protein heterodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Differentiation, Mitosis, Spermatogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-7
Alternative name(s):
CDC10 protein homolog
Gene namesi
Name:Sept7
Synonyms:Cdc10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1335094 Sept7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001735292 – 436Septin-7Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei29PhosphotyrosineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei372N6-acetyllysineCombined sources1
Modified residuei423PhosphoserineBy similarity1
Modified residuei425PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO55131
MaxQBiO55131
PaxDbiO55131
PeptideAtlasiO55131
PRIDEiO55131

PTM databases

iPTMnetiO55131
PhosphoSitePlusiO55131
SwissPalmiO55131

Expressioni

Gene expression databases

CleanExiMM_SEPT7

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5, SEPT8, SEPT9 and SEPT11. Component of a septin core octomeric complex consisting of SEPT12, SEPT7, SEPT6 and SEPT2 or SEPT4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus; the SEPT12:SEPT7 association is mediated by the respective GTP-binding domains (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231619, 18 interactors
IntActiO55131, 12 interactors
MINTiO55131
STRINGi10090.ENSMUSP00000127641

Structurei

3D structure databases

ProteinModelPortaliO55131
SMRiO55131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 315Septin-type GPROSITE-ProRule annotationAdd BLAST270

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 316Interaction with SEPT12By similarityAdd BLAST271
Regioni56 – 63G1 motifPROSITE-ProRule annotation8
Regioni112 – 115G3 motifPROSITE-ProRule annotation4
Regioni193 – 196G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili331 – 436Sequence analysisAdd BLAST106

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiO55131
KOiK16944
PhylomeDBiO55131

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR008115 Septin7
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
PRINTSiPR01742 SEPTIN7
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O55131-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVSARSAAA EERSVNCGTM AQPKNLEGYV GFANLPNQVY RKSVKRGFEF
60 70 80 90 100
TLMVVGESGL GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK
110 120 130 140 150
EGGVQLLLTI VDTPGFGDAV DNSNCWQPVI DYIDSKFEDY LNAESRVNRR
160 170 180 190 200
QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK RLHEKVNIIP LIAKADTLTP
210 220 230 240 250
EECQQFKKQI MKEIQEHKIK IYEFPETDDE EENKLVKKIK DRLPLAVVGS
260 270 280 290 300
NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT
310 320 330 340 350
NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK
360 370 380 390 400
KMEMEMEQVF EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR
410 420 430
RQFEEEKANW EAQQRILEQQ NSSRTLEKNK KKGKIF
Length:436
Mass (Da):50,550
Last modified:June 1, 1998 - v1
Checksum:i1028CCF14023059C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1G8E9Q1G8_MOUSE
Septin-7
Sept7
437Annotation score:
E9Q9F5E9Q9F5_MOUSE
Septin-7
Sept7
437Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223782
, AJ223783, AJ223784, AJ223785, AJ223786, AJ223787, AJ223788, AJ223789, AJ223790, AJ223791, AJ223792, AJ223793, AJ223794 Genomic DNA Translation: CAA11547.1
BC058587 mRNA Translation: AAH58587.1
RefSeqiNP_001192296.1, NM_001205367.1
UniGeneiMm.270259

Genome annotation databases

GeneIDi235072
KEGGimmu:235072

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223782
, AJ223783, AJ223784, AJ223785, AJ223786, AJ223787, AJ223788, AJ223789, AJ223790, AJ223791, AJ223792, AJ223793, AJ223794 Genomic DNA Translation: CAA11547.1
BC058587 mRNA Translation: AAH58587.1
RefSeqiNP_001192296.1, NM_001205367.1
UniGeneiMm.270259

3D structure databases

ProteinModelPortaliO55131
SMRiO55131
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231619, 18 interactors
IntActiO55131, 12 interactors
MINTiO55131
STRINGi10090.ENSMUSP00000127641

PTM databases

iPTMnetiO55131
PhosphoSitePlusiO55131
SwissPalmiO55131

Proteomic databases

EPDiO55131
MaxQBiO55131
PaxDbiO55131
PeptideAtlasiO55131
PRIDEiO55131

Protocols and materials databases

DNASUi235072
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi235072
KEGGimmu:235072

Organism-specific databases

CTDi989
MGIiMGI:1335094 Sept7

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiO55131
KOiK16944
PhylomeDBiO55131

Miscellaneous databases

ChiTaRSiSept7 mouse
PROiPR:O55131
SOURCEiSearch...

Gene expression databases

CleanExiMM_SEPT7

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR008115 Septin7
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
PRINTSiPR01742 SEPTIN7
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT7_MOUSE
AccessioniPrimary (citable) accession number: O55131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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