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Protein

Cytochrome P450 26A1

Gene

Cyp26a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.2 Publications
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • cellular response to retinoic acid Source: UniProtKB
  • central nervous system development Source: MGI
  • neural crest cell development Source: MGI
  • oxidation-reduction process Source: GO_Central
  • retinoic acid catabolic process Source: MGI
  • retinoic acid metabolic process Source: UniProtKB
  • retinoic acid receptor signaling pathway Source: MGI
  • sterol metabolic process Source: GO_Central
  • xenobiotic metabolic process Source: UniProtKB

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26A1 (EC:1.14.13.-2 Publications)
Alternative name(s):
Cytochrome P450RAI
Retinoic acid 4-hydroxylase
Retinoic acid-metabolizing cytochrome
Gene namesi
Name:Cyp26a1
Synonyms:Cyp26, P450ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1096359 Cyp26a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519811 – 497Cytochrome P450 26A1Add BLAST497

Proteomic databases

MaxQBiO55127
PaxDbiO55127
PRIDEiO55127

PTM databases

iPTMnetiO55127
PhosphoSitePlusiO55127

Expressioni

Inductioni

By retinoic acid.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025946

Structurei

3D structure databases

ProteinModelPortaliO55127
SMRiO55127
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
HOGENOMiHOG000220829
HOVERGENiHBG051099
InParanoidiO55127
KOiK07437
PhylomeDBiO55127
TreeFamiTF105093

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002403 Cyt_P450_E_grp-IV
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00465 EP450IV
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O55127-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG
60 70 80 90 100
FPFFGETLQM VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI
110 120 130 140 150
LLGEHRLVSV HWPASVRTIL GAGCLSNLHD SSHKQRKKVI MQAFSREALQ
160 170 180 190 200
CYVLVIAEEV SSCLEQWLSC GERGLLVYPE VKRLMFRIAM RILLGCEPGP
210 220 230 240 250
AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR NLIHARIEEN
260 270 280 290 300
IRAKIRRLQA TEPDGGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG
310 320 330 340 350
GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSN QDNKLDMETL
360 370 380 390 400
EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD
410 420 430 440 450
THDVADIFTN KEEFNPDRFI VPHPEDASRF SFIPFGGGLR SCVGKEFAKI
460 470 480 490
LLKIFTVELA RHCDWQLLNG PPTMKTSPTV YPVDNLPARF TYFQGDI
Length:497
Mass (Da):56,178
Last modified:June 1, 1998 - v1
Checksum:i33B07D7C29134471
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J061A0A0R4J061_MOUSE
Cytochrome P450 26A1
Cyp26a1 mCG_13915
497Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → T in AAD17217 (PubMed:11063033).Curated1
Sequence conflicti154L → P in AAH12673 (PubMed:15489334).Curated1
Sequence conflicti356I → T in AAH12673 (PubMed:15489334).Curated1
Sequence conflicti492Y → H in AAH12673 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12657 mRNA Translation: CAA73206.1
AF115769 mRNA Translation: AAD17217.1
BC012673 mRNA Translation: AAH12673.1
CCDSiCCDS29780.1
RefSeqiNP_031837.2, NM_007811.2
UniGeneiMm.42230

Genome annotation databases

GeneIDi13082
KEGGimmu:13082
UCSCiuc008his.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12657 mRNA Translation: CAA73206.1
AF115769 mRNA Translation: AAD17217.1
BC012673 mRNA Translation: AAH12673.1
CCDSiCCDS29780.1
RefSeqiNP_031837.2, NM_007811.2
UniGeneiMm.42230

3D structure databases

ProteinModelPortaliO55127
SMRiO55127
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025946

PTM databases

iPTMnetiO55127
PhosphoSitePlusiO55127

Proteomic databases

MaxQBiO55127
PaxDbiO55127
PRIDEiO55127

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13082
KEGGimmu:13082
UCSCiuc008his.2 mouse

Organism-specific databases

CTDi1592
MGIiMGI:1096359 Cyp26a1

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
HOGENOMiHOG000220829
HOVERGENiHBG051099
InParanoidiO55127
KOiK07437
PhylomeDBiO55127
TreeFamiTF105093

Miscellaneous databases

PROiPR:O55127
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002403 Cyt_P450_E_grp-IV
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00465 EP450IV
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP26A_MOUSE
AccessioniPrimary (citable) accession number: O55127
Secondary accession number(s): Q9R1F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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