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Protein
Submitted name:

M-protein

Gene

Myom2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • kinase binding Source: MGI
  • muscle alpha-actinin binding Source: GO_Central
  • structural constituent of cytoskeleton Source: MGI
  • structural constituent of muscle Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
M-proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myom2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1328358 Myom2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
O55124

PRoteomics IDEntifications database

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PRIDEi
O55124

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O55124 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O55124, 3 interactors

Molecular INTeraction database

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MINTi
O55124

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O55124

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 245Ig-likeInterPro annotationAdd BLAST92
Domaini266 – 354Ig-likeInterPro annotationAdd BLAST89
Domaini385 – 480Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini513 – 608Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini614 – 707Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini710 – 812Fibronectin type-IIIInterPro annotationAdd BLAST103
Domaini815 – 912Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini904 – 1002Ig-likeInterPro annotationAdd BLAST99
Domaini1130 – 1211Ig-likeInterPro annotationAdd BLAST82
Domaini1358 – 1434Ig-likeInterPro annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili101 – 128Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293283

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004977

Database of Orthologous Groups

More...
OrthoDBi
57219at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O55124-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVAVPFYQ KRHKHFDQSY RNIQTRYLLD QYALKKQATT QSSSQRSLTE
60 70 80 90 100
RSSSKRASSQ SSAGAMTCRL CAKRVSASEE EEVENENRYR SQAASYGEAK
110 120 130 140 150
RQRFLSELAQ LEENVHLARS QARDKLDKYF LEQTVEDNLA WERHSFEDRM
160 170 180 190 200
SRAPEILVRL RSHTIWERMS VRLCFTVQGF PTPVVQWYKD GSLICQAGEP
210 220 230 240 250
GKYRIKSRYG VHTLEINRAN FEDTATYSAV ATNSHEQVST NAAVVVRRYR
260 270 280 290 300
GEEEPFHSVG LPIGLPLSSV IPYTHFDVQI FGVFGVTFGG EGETVTLKCT
310 320 330 340 350
LLVTPDLRRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLNKDDE
360 370 380 390 400
GLYTLRIVSR GGVSDHSAFM FVRDADPLVT GAPGAPMDLQ CHDANRDYVI
410 420 430 440 450
VTWKPPNTTT ESPVIGYFID KCEVGTNNWV QCNDAPVKIC KYPVTGLFEG
460 470 480 490 500
RSYVFRVRAV NNAGISRPSR ISDAVAALDP VDLRRLQAIH LEGEKEIVIY
510 520 530 540 550
QDDLEGDVQI PGPPTNVQAS EVSRNYVVLS WDPPSPRGKD PLMYFIEKSA
560 570 580 590 600
VGSGSWQRVN AQTAVRSPRY AVFDLAEGKS YVFRVLSANK HGLSDPSEIT
610 620 630 640 650
PPIQAQDMIV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV
660 670 680 690 700
AGTNMWEPCN HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GTSENSQESE
710 720 730 740 750
VIKVQAALTV PSHPYGITLL NCDGHSMTLG WKVPKFSGGS AIIGYYLDKR
760 770 780 790 800
EVHHKNWHEV NSSPVKERIL TVEGLTEGSL YEFKIAATNL AGIGQPSDPS
810 820 830 840 850
EHFKCEAWTD PEPGPAYDLT FCEVRDTSLV ILWKAPVYSG SSPVSGYFVD
860 870 880 890 900
FKEEDSGEWK TTSEAATPNR YLKVCDLQQG KTYVFRIRAV NASGPGKPSD
910 920 930 940 950
TSEPVLVEAR PGTKEISAGV DEEGNIYLGF DCQEMTDASQ FTWCKAYEEI
960 970 980 990 1000
ADEERFEVHT EGDHSKLYFK NPDKEDIGTY SVSVSDTDGV SSSFVLDEEE
1010 1020 1030 1040 1050
LERLMALSNE IKNPTIPLKS ELAYEIFDKG QVRFWLQAEH LSPDASFRFI
1060 1070 1080 1090 1100
INDREVSDSD THRIKCDRST GMIEMVMDRF TIENEGTYTV QIQDGKAKNQ
1110 1120 1130 1140 1150
SSLVLIGDAF KAVLEEAEFQ RKEFLRKQGP HFAEYLHWDV TEECEVRLVC
1160 1170 1180 1190 1200
KVANTKRETV FKWLKDDVLY ETETPPDLEK GVCELLIPKL SKKDHGEYKA
1210 1220 1230 1240 1250
TLKDDRGQDV SVLEVGGKVY EDMILAMSRV CGASASPLKV LCTPEGIRLQ
1260 1270 1280 1290 1300
CFMKYFTEEM KVSWYHKEAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK
1310 1320 1330 1340 1350
YTFEIFDGKD SHQRSLDLSG QAFDEAYAEF QQLKAAAFAE KNRGKVIGGL
1360 1370 1380 1390 1400
PDVVTIMEGK TLNLTCTVFG NPDPEVVWFK NDKDIELSEH FLVKMEQSKY
1410 1420 1430 1440 1450
VSLTIQGVTA EDSGKYSINV KNKYGGEKID VTVSVYKHGE KIPDISPPQQ
1460
AKPKLIPAST SSD
Length:1,463
Mass (Da):164,519
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C6551ED90F0B288
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ001038 mRNA Translation: CAA04492.1

NCBI Reference Sequences

More...
RefSeqi
NP_032690.2, NM_008664.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.272115

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17930

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17930

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001038 mRNA Translation: CAA04492.1
RefSeqiNP_032690.2, NM_008664.2
UniGeneiMm.272115

3D structure databases

ProteinModelPortaliO55124
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO55124, 3 interactors
MINTiO55124

Proteomic databases

PeptideAtlasiO55124
PRIDEiO55124

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17930
KEGGimmu:17930

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9172
MGIiMGI:1328358 Myom2

Phylogenomic databases

eggNOGiENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA
HOGENOMiHOG000293283
HOVERGENiHBG004977
OrthoDBi57219at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiO55124 MM

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO55124_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O55124
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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