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Entry version 114 (12 Aug 2020)
Sequence version 2 (09 Feb 2010)
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Protein

AF4/FMR2 family member 2

Gene

Aff2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF4/FMR2 family member 2
Alternative name(s):
FMR2P
Fragile X mental retardation protein 2 homolog
Short name:
Protein FMR-2
Protein Ox19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aff2
Synonyms:Fmr2, Ox19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1202294, Aff2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002159131 – 1272AF4/FMR2 family member 2Add BLAST1272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei395PhosphoserineBy similarity1
Modified residuei482PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O55112

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O55112

PRoteomics IDEntifications database

More...
PRIDEi
O55112

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O55112

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O55112

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the hippocampus, the piriform cortex, Purkinje cells and the cingulate gyrus.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed before day 7 in the embryo and reached its highest levels at 10.5-11.5 days. In the embryo at day 11, expression is more specific in the roof of the hind brain and the lateral ventricle of the brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031189, Expressed in Ammon's horn and 125 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O55112, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
199717, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033532

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O55112, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O55112

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR32, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O55112

KEGG Orthology (KO)

More...
KOi
K15194

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPEWPRD

Database of Orthologous Groups

More...
OrthoDBi
558558at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O55112

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, TF_AF4/FMR2

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05110, AF-4, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O55112-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLFDFFRDW DLEQQCHYEQ DRSALKKREW ERRNQEVQQE EDLFSSGFDL
60 70 80 90 100
FGEPYKVAEY TNKGDALANR VQNTLGSYDE MKDLLSNHSS QNHLVGIPKN
110 120 130 140 150
SAPQTPISKS EASFYPEQKN RMIPSHQETT HSSTPMPPPS VVILNSTLIH
160 170 180 190 200
SNRKSKSEWP RDSHNTSPAQ ASQTSSQPNK MQTSTQDPPQ TRLEDFFVYP
210 220 230 240 250
AEQPQIGTVE KSNPSSKEEN NPNSGGEDTF KEIFQSNSPE ESEFTVQAPG
260 270 280 290 300
SPLVASSLLA PSSGLSVPTF PPGLYCKTSM GQQKPTAYVR PMDGQDQATD
310 320 330 340 350
ISPTLKPSIE FENSFGNLSF GSLLDGKPSA VSSKTKLPKF TILQTSEVSL
360 370 380 390 400
TSDPSCVEEI LRESQHLTPG FTLQKWSDPS SRASTKMLED DLKLSSDEDD
410 420 430 440 450
LEPVKTLTTQ CTANELYQAV EKAKPKNNPV NPLLATPQST PATQTNVGSG
460 470 480 490 500
SSSESESSSE SDSDTESSTT DSESNEAPRV ATPEPEPPST NKWQLDKWLN
510 520 530 540 550
KVTSQNKSFI CGQNETPTET ISLPPPIIQP VEVQVKVKPN PSQAVAVPKE
560 570 580 590 600
RPLLSLIREK ARPRPTQKTP ETKALKHKLS TSVDTVSQRT IGKKQPKKVE
610 620 630 640 650
KNTSFEEFTW PKPNITNSTP KEKGSVELPD PPRSRNKATA HKPVPRKEPR
660 670 680 690 700
PHVPLATEKK KYRGPGKIVP KSREFIETDS STSDSNTDQE ETLQIKVLPP
710 720 730 740 750
CITSKSKETS NASLTLSTLT NGNSNNLSTS NEETAFSPPP AMQTELLSPL
760 770 780 790 800
RDHENPKNLW VKIDLDLLSR VPGQNSVPVT PAKTDYKETA SKPKRQTAAT
810 820 830 840 850
AVEKPAPKGK RKHKPAETAE KIPEKKQRLE DNTTICLLPP CISPAPPHKP
860 870 880 890 900
PSTRENSSRR ANRKKEEKLF PPALSPLAED PPRRRNVSGN NGHFGQDKNI
910 920 930 940 950
SMAGQITSSK PKRSEGKFCA TFKGISINEG DAPKKAASAT VTVANMALAT
960 970 980 990 1000
ATATATVPAI VTATVTATAT TTATATTTTT TTTISSITPT ITSGLMDSSH
1010 1020 1030 1040 1050
LEMTSWAALP LLSSSSANVR RPKLTFDDSV HNADFYMQEA KKLKHKADAL
1060 1070 1080 1090 1100
FEKFGKAVNY ADAALSFTEC GNAMERDPLE AKSPYTMYSE TVELLRYAMR
1110 1120 1130 1140 1150
LKNFASPLAS DGDKKLAVLC YRCLSLLYLR MFKLKKDHAM KYSRSLMEYF
1160 1170 1180 1190 1200
KQNASKVTQI PSPWVGNGKN TPSPVSLNNV SPINSVGNCN NGPVTIPQRI
1210 1220 1230 1240 1250
HHMAASHVNI TSNVLRGYEH WDMADKLTRD NKEFFGDLDT LMGPLTQHSS
1260 1270
MTNLVRYVRQ GLCWLRIDAH LL
Length:1,272
Mass (Da):140,181
Last modified:February 9, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CE41F1AEFE9C2B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti432P → S in CAA04821 (PubMed:9467002).Curated1
Sequence conflicti544A → S in CAA04821 (PubMed:9467002).Curated1
Sequence conflicti941V → A in CAA04821 (PubMed:9467002).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ001549 mRNA Translation: CAA04821.1
AL663113 Genomic DNA No translation available.
AL672120 Genomic DNA No translation available.
AL808131 Genomic DNA No translation available.
BX294655 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30173.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T30248

NCBI Reference Sequences

More...
RefSeqi
NP_032058.2, NM_008032.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033532; ENSMUSP00000033532; ENSMUSG00000031189

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14266

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14266

UCSC genome browser

More...
UCSCi
uc009tjb.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001549 mRNA Translation: CAA04821.1
AL663113 Genomic DNA No translation available.
AL672120 Genomic DNA No translation available.
AL808131 Genomic DNA No translation available.
BX294655 Genomic DNA No translation available.
CCDSiCCDS30173.1
PIRiT30248
RefSeqiNP_032058.2, NM_008032.3

3D structure databases

SMRiO55112
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199717, 2 interactors
STRINGi10090.ENSMUSP00000033532

PTM databases

iPTMnetiO55112
PhosphoSitePlusiO55112

Proteomic databases

EPDiO55112
PaxDbiO55112
PRIDEiO55112

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
529, 148 antibodies

The DNASU plasmid repository

More...
DNASUi
14266

Genome annotation databases

EnsembliENSMUST00000033532; ENSMUSP00000033532; ENSMUSG00000031189
GeneIDi14266
KEGGimmu:14266
UCSCiuc009tjb.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2334
MGIiMGI:1202294, Aff2

Phylogenomic databases

eggNOGiENOG502QR32, Eukaryota
GeneTreeiENSGT00950000182974
HOGENOMiCLU_006484_0_0_1
InParanoidiO55112
KOiK15194
OMAiKPEWPRD
OrthoDBi558558at2759
PhylomeDBiO55112
TreeFamiTF326216

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
14266, 2 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Aff2, mouse

Protein Ontology

More...
PROi
PR:O55112
RNActiO55112, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031189, Expressed in Ammon's horn and 125 other tissues
GenevisibleiO55112, MM

Family and domain databases

InterProiView protein in InterPro
IPR007797, TF_AF4/FMR2
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF05110, AF-4, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAFF2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O55112
Secondary accession number(s): B1ATW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 9, 2010
Last modified: August 12, 2020
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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