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Protein

Desmoglein-2

Gene

Dsg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-351906 Apoptotic cleavage of cell adhesion proteins
R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-2
Gene namesi
Name:Dsg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1196466 Dsg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini55 – 618ExtracellularSequence analysisAdd BLAST564
Transmembranei619 – 639HelicalSequence analysisAdd BLAST21
Topological domaini640 – 1122CytoplasmicSequence analysisAdd BLAST483

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000000384729 – 54Sequence analysisAdd BLAST26
ChainiPRO_000000384855 – 1122Desmoglein-2Add BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei685PhosphoserineBy similarity1
Modified residuei706PhosphoserineBy similarity1
Modified residuei709PhosphoserineBy similarity1
Modified residuei729PhosphoserineCombined sources1
Modified residuei808PhosphothreonineBy similarity1
Modified residuei810PhosphoserineBy similarity1
Modified residuei814PhosphoserineBy similarity1
Modified residuei819PhosphoserineBy similarity1
Modified residuei1122PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO55111
PaxDbiO55111
PeptideAtlasiO55111
PRIDEiO55111

PTM databases

iPTMnetiO55111
PhosphoSitePlusiO55111
SwissPalmiO55111

Expressioni

Tissue specificityi

Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during.2 Publications

Gene expression databases

BgeeiENSMUSG00000044393 Expressed in 264 organ(s), highest expression level in left colon
CleanExiMM_DSG2
ExpressionAtlasiO55111 baseline and differential
GenevisibleiO55111 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057096

Structurei

3D structure databases

ProteinModelPortaliO55111
SMRiO55111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 164Cadherin 1PROSITE-ProRule annotationAdd BLAST110
Domaini165 – 277Cadherin 2PROSITE-ProRule annotationAdd BLAST113
Domaini278 – 398Cadherin 3PROSITE-ProRule annotationAdd BLAST121
Domaini397 – 504Cadherin 4PROSITE-ProRule annotationAdd BLAST108
Repeati885 – 916Desmoglein repeat 1Add BLAST32
Repeati917 – 945Desmoglein repeat 2Add BLAST29
Repeati946 – 971Desmoglein repeat 3Add BLAST26
Repeati972 – 995Desmoglein repeat 4Add BLAST24
Repeati996 – 1024Desmoglein repeat 5Add BLAST29
Repeati1025 – 1055Desmoglein repeat 6Add BLAST31

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiO55111
KOiK07597
OMAiLLLMCHC
OrthoDBiEOG091G01F3
TreeFamiTF331809

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O55111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV
60 70 80 90 100
RQKRAWITAP VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT
110 120 130 140 150
EPPFGIFVFD RNTGELNITS ILDREETPYF LLTGYALDSR GNNLEKPLEL
160 170 180 190 200
RIKVLDINDN EPVFTQEVFV GSIEELSAAH TLVMKITATD ADDPETLNAK
210 220 230 240 250
VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY SLTVEARDGN
260 270 280 290 300
GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV
310 320 330 340 350
TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM
360 370 380 390 400
KKLDLSIIVT NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF
410 420 430 440 450
RASEAMDRSS LSRSIGNFQV FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS
460 470 480 490 500
EIKLVKIPDF ESRYVQNGTY TAKVVAISKE HPQKTITGTI VITVEDVNDN
510 520 530 540 550
CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID QPPGTAQKWK
560 570 580 590 600
ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK
610 620 630 640 650
GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT
660 670 680 690 700
PIPGTIEMLH PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG
710 720 730 740 750
MMKGSSSASV TKGQHELSEV DGRWEEHRSL LTAGATHHVR TAGTIAANEA
760 770 780 790 800
VRTRATGSSR DMSGARGAVA VNEEFLRSYF TEKAASYNGE DDLHMAKDCL
810 820 830 840 850
LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL AEVCLGRKID
860 870 880 890 900
LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE
910 920 930 940 950
VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP
960 970 980 990 1000
PSTVLLAPRQ PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG
1010 1020 1030 1040 1050
IPKPLEVTQH LKDAQYVMVR ERESILAPSS GVQPTLAMPS VAAGGQNVTV
1060 1070 1080 1090 1100
TERILTPAST LQSSYQIPSE TSITARNTVL SSVGSIGPLP NLDLEESDRP
1110 1120
NSTITTSSTR VTKHSTMQHS YS
Length:1,122
Mass (Da):122,385
Last modified:July 27, 2011 - v3
Checksum:i9EB9CD402632437A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q811I1Q811I1_MOUSE
Desmoglein-2
Dsg2
360Annotation score:
Q8VCE3Q8VCE3_MOUSE
Desmoglein-2
Dsg2
292Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti304D → Y in BAB86843 (Ref. 1) Curated1
Sequence conflicti358I → L in AAH34056 (PubMed:15489334).Curated1
Sequence conflicti480E → D in AAH34056 (PubMed:15489334).Curated1
Sequence conflicti491V → I in AAH34056 (PubMed:15489334).Curated1
Sequence conflicti863R → T in BAB86843 (Ref. 1) Curated1
Sequence conflicti899H → R in BAB86843 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072269 mRNA Translation: BAB86843.1
BC034056 mRNA Translation: AAH34056.1
BC131653 mRNA Translation: AAI31654.1
BC131654 mRNA Translation: AAI31655.1
AJ000328 mRNA Translation: CAA03995.1
CCDSiCCDS29084.1
RefSeqiNP_031909.2, NM_007883.3
UniGeneiMm.345891

Genome annotation databases

EnsembliENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393
GeneIDi13511
KEGGimmu:13511
UCSCiuc008ees.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072269 mRNA Translation: BAB86843.1
BC034056 mRNA Translation: AAH34056.1
BC131653 mRNA Translation: AAI31654.1
BC131654 mRNA Translation: AAI31655.1
AJ000328 mRNA Translation: CAA03995.1
CCDSiCCDS29084.1
RefSeqiNP_031909.2, NM_007883.3
UniGeneiMm.345891

3D structure databases

ProteinModelPortaliO55111
SMRiO55111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057096

PTM databases

iPTMnetiO55111
PhosphoSitePlusiO55111
SwissPalmiO55111

Proteomic databases

MaxQBiO55111
PaxDbiO55111
PeptideAtlasiO55111
PRIDEiO55111

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393
GeneIDi13511
KEGGimmu:13511
UCSCiuc008ees.2 mouse

Organism-specific databases

CTDi1829
MGIiMGI:1196466 Dsg2

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiO55111
KOiK07597
OMAiLLLMCHC
OrthoDBiEOG091G01F3
TreeFamiTF331809

Enzyme and pathway databases

ReactomeiR-MMU-351906 Apoptotic cleavage of cell adhesion proteins
R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiDsg2 mouse
PROiPR:O55111
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044393 Expressed in 264 organ(s), highest expression level in left colon
CleanExiMM_DSG2
ExpressionAtlasiO55111 baseline and differential
GenevisibleiO55111 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDSG2_MOUSE
AccessioniPrimary (citable) accession number: O55111
Secondary accession number(s): A2RRJ0, Q8K069, Q8R517
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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