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Protein

Striatin

Gene

Strn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin
Gene namesi
Name:Strn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1333757 Strn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512331 – 780StriatinAdd BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphoserineCombined sources1
Modified residuei225PhosphothreonineCombined sources1
Modified residuei227PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei245PhosphoserineCombined sources1
Modified residuei259PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO55106
MaxQBiO55106
PaxDbiO55106
PeptideAtlasiO55106
PRIDEiO55106

PTM databases

iPTMnetiO55106
PhosphoSitePlusiO55106

Miscellaneous databases

PMAP-CutDBiO55106

Expressioni

Tissue specificityi

Mainly expressed in brain but is also expressed at low levels in various tissues such as kidney, spleen, skeletal muscle and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000024077 Expressed in 277 organ(s), highest expression level in secondary oocyte
CleanExiMM_STRN
ExpressionAtlasiO55106 baseline and differential
GenevisibleiO55106 MM

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234590, 8 interactors
IntActiO55106, 33 interactors
MINTiO55106
STRINGi10090.ENSMUSP00000120830

Structurei

3D structure databases

ProteinModelPortaliO55106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati461 – 500WD 1Add BLAST40
Repeati514 – 553WD 2Add BLAST40
Repeati567 – 606WD 3Add BLAST40
Repeati662 – 701WD 4Add BLAST40
Repeati704 – 743WD 5Add BLAST40
Repeati750 – 779WD 6Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 63Caveolin-bindingSequence analysis9
Regioni149 – 166Calmodulin-bindingSequence analysisAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 120Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 45Poly-Ala9

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642 Eukaryota
ENOG410XR31 LUCA
GeneTreeiENSGT00520000055597
HOGENOMiHOG000236343
HOVERGENiHBG007117
InParanoidiO55106
KOiK17608
OMAiFNMETRQ
OrthoDBiEOG091G0509
PhylomeDBiO55106
TreeFamiTF313387

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013258 Striatin_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08232 Striatin, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O55106-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP
60 70 80 90 100
GILHFLQHEW ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR
110 120 130 140 150
RIKMLEYALK QERAKYHKLK YGTELNQGDM KPPSYDSDEG NETEVQPQQN
160 170 180 190 200
SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS KRVRALLGFS SDVTDREDDK
210 220 230 240 250
NQDSVINGTE AEVKETAMIG KSELTDSASV LDNFKFLESA AADVSDEDED
260 270 280 290 300
EDTDGRAKSV IDTSTIVRKK ALPDTSEDRD TKEALKEFDF LVTSEEGDNE
310 320 330 340 350
SRSAGDGTDW EKEDQCLTPE AWNVDQGVIS KLKEQYKKER KGKKGVKRPN
360 370 380 390 400
RSKLQDMLAN LRDVDELPSL QPSVGSPSRP SSSRLPEQEL SRADEVEALT
410 420 430 440 450
FPPSSGKSFI MGADEALESE LGLGELAGLT VANEADSLAY DIANNKDALR
460 470 480 490 500
KTWNPKFTLR SHFDGIRALA FHPIEPVLIT ASEDHTLKMW NLQKTAPAKK
510 520 530 540 550
STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGRI QSWSTTNPNV
560 570 580 590 600
DPYDAYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE
610 620 630 640 650
VAPALSVFND NQELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRV
660 670 680 690 700
LTLESNVDST SSSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH
710 720 730 740 750
SMVAHLEAVT SLAVDPNGLY LMSGSHDCSI RLWNLESKTC IQEFTAHRKK
760 770 780
FEESIHDVAF HPSKCYIASA GADALAKVFV
Length:780
Mass (Da):85,966
Last modified:July 27, 2011 - v2
Checksum:iDC1C1D98E9E5BC08
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WH41F8WH41_MOUSE
Striatin
Strn
627Annotation score:
F6Z700F6Z700_MOUSE
Striatin
Strn
267Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244V → F in CAA11545 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223777 mRNA Translation: CAA11545.1
BC090968 mRNA Translation: AAH90968.1
BC150727 mRNA Translation: AAI50728.1
CCDSiCCDS28978.1
RefSeqiNP_035630.2, NM_011500.2
UniGeneiMm.311915
Mm.391038
Mm.486430

Genome annotation databases

EnsembliENSMUST00000145910; ENSMUSP00000120830; ENSMUSG00000024077
GeneIDi268980
KEGGimmu:268980
UCSCiuc008doz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223777 mRNA Translation: CAA11545.1
BC090968 mRNA Translation: AAH90968.1
BC150727 mRNA Translation: AAI50728.1
CCDSiCCDS28978.1
RefSeqiNP_035630.2, NM_011500.2
UniGeneiMm.311915
Mm.391038
Mm.486430

3D structure databases

ProteinModelPortaliO55106
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234590, 8 interactors
IntActiO55106, 33 interactors
MINTiO55106
STRINGi10090.ENSMUSP00000120830

PTM databases

iPTMnetiO55106
PhosphoSitePlusiO55106

Proteomic databases

EPDiO55106
MaxQBiO55106
PaxDbiO55106
PeptideAtlasiO55106
PRIDEiO55106

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000145910; ENSMUSP00000120830; ENSMUSG00000024077
GeneIDi268980
KEGGimmu:268980
UCSCiuc008doz.1 mouse

Organism-specific databases

CTDi6801
MGIiMGI:1333757 Strn

Phylogenomic databases

eggNOGiKOG0642 Eukaryota
ENOG410XR31 LUCA
GeneTreeiENSGT00520000055597
HOGENOMiHOG000236343
HOVERGENiHBG007117
InParanoidiO55106
KOiK17608
OMAiFNMETRQ
OrthoDBiEOG091G0509
PhylomeDBiO55106
TreeFamiTF313387

Miscellaneous databases

PMAP-CutDBiO55106
PROiPR:O55106
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024077 Expressed in 277 organ(s), highest expression level in secondary oocyte
CleanExiMM_STRN
ExpressionAtlasiO55106 baseline and differential
GenevisibleiO55106 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013258 Striatin_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08232 Striatin, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTRN_MOUSE
AccessioniPrimary (citable) accession number: O55106
Secondary accession number(s): B2RWV9, Q5BKR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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