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Protein

Periaxin

Gene

Prx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells (PubMed:11430802, PubMed:21745462, PubMed:22764250). Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli (PubMed:10839370). Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions (PubMed:15356632). Required for normal remyelination after nerve injury (PubMed:10839370). Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses (PubMed:15356632, PubMed:23022068). Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions (PubMed:15356632, PubMed:23022068). Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves (PubMed:23022068, PubMed:22764250). Recruits DRP2 to the Schwann cell plasma membrane (PubMed:11430802, PubMed:23022068, PubMed:22764250). Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology (PubMed:21745462).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • peripheral nervous system myelin formation Source: UniProtKB
  • peripheral nervous system myelin maintenance Source: UniProtKB
  • regulation of RNA splicing Source: UniProtKB
  • sensory perception of pain Source: UniProtKB
  • transmission of nerve impulse Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periaxin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prx
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108176 Prx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are born at the expected Mendelian rate and appear grossly normal during the first six weeks of life. After six to nine months, they display pronounced unsteadiness of gait and difficulty in supporting themselves on their hindlimbs, weight loss due to an inability to feed and labored respiration (PubMed:10839370). Their sensory, motor and vagus nerves show extensive demyelination with demyelinated segments surrounded by focal thickenings (PubMed:10839370, PubMed:18205176). In contrast, the predominantly sensory saphenous nerves are extensively hypermyelinated, resulting in myelin sheath infolding and axon compression (PubMed:10839370). At eight months, naked or thinly myelinated axons are common in sciatic nerve fibers (PubMed:10839370). Already at six weeks, mutant mice display markedly increased sensitivity to noxious mechanical and thermal stimuli (PubMed:10839370). Besides, four month old mutant mice display impaired remyelination after crush injury (PubMed:10839370). Schwann cells from mutant mice display a reduced rate of elongation, leading to decreased distances between nodes of Ranvier and reduced velocity of the transmission of nerve impulses; this results in impaired motor skills on the RotaRod in three week old mice (PubMed:15356632). Peripheral nerves show decreased conduction velocity, due to defects in the myelin sheath (PubMed:10839370). Motor axons from five month old mice show an increased number of preterminal branches that arise from demyelinated regions close to the neuromuscular junction (PubMed:18205176). In contrast, axon branching close to the neuromuscular junction appears normal in three week old mice (PubMed:18205176). At the molecular level, gene disruption impairs formation of Cajal bands and location of Drp2 in patches that colocalize with appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane (PubMed:15356632). Cytoplasm from mutant Schwann cells forms a concentric ring under the cell membrane, instead of being strictly compartmentalized at Cajal bands (PubMed:15356632). The transport of the mRNA coding for Mbp is impaired; the mRNA level is highest in the perinuclear region and does not accumulate in the paranodal region (PubMed:15356632). Eye lenses from 90 day old mutant mice appear grossly normal at the macroscopic level, but display altered shape and organization of inner lens fiber cells, together with alteration in the membrane localization of Mip, Ezr and Ahnak (PubMed:21745462).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000585641 – 1391PeriaxinAdd BLAST1391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei848PhosphoserineBy similarity1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1028PhosphoserineBy similarity1
Modified residuei1279PhosphoserineCombined sources1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1285PhosphoserineCombined sources1
Modified residuei1293PhosphoserineCombined sources1
Modified residuei1331PhosphoserineBy similarity1
Modified residuei1337PhosphoserineCombined sources1
Modified residuei1369PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O55103

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O55103

PeptideAtlas

More...
PeptideAtlasi
O55103

PRoteomics IDEntifications database

More...
PRIDEi
O55103

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O55103

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O55103

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in myelinating Schwann cells in intramuscular nerves in triangularis sterni (PubMed:18205176). Detected in sciatic nerve (PubMed:11430802). Detected in eye lens fiber cells (PubMed:21745462). Isoform 1 is detected in myelinating Schwann cells in sciatic nerve (PubMed:9488714, PubMed:10671475, PubMed:10839370). Isoform 2 is detected in myelinating Schwann cells in sciatic nerve (at protein level) (PubMed:9488714, PubMed:10839370). Detected in sciatic nerve (PubMed:9488714, PubMed:10839370).6 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryonic eye lens; levels increase steadily from 10.5 dpc onto birth and continue to increase during the first three weeks after birth.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000053198 Expressed in 199 organ(s), highest expression level in sciatic nerve

CleanEx database of gene expression profiles

More...
CleanExi
MM_PRX

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O55103 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O55103 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (via PDZ domain) (By similarity). Interacts with SCN10A. Found in a complex with SCN10A (By similarity). Interacts with DRP2 (PubMed:22764250). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (PubMed:11430802). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX (By similarity). Identified in a complex with EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, VIM and spectrin (PubMed:21745462).By similarity3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
202408, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O55103

Protein interaction database and analysis system

More...
IntActi
O55103, 2 interactors

Molecular INTeraction database

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MINTi
O55103

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000096241

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O55103

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O55103

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 99PDZPROSITE-ProRule annotationAdd BLAST84
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati432 – 43615
Repeati440 – 44425
Repeati448 – 45235
Repeati456 – 46045
Repeati464 – 46855
Repeati469 – 47365
Repeati474 – 47875
Repeati482 – 48685
Repeati487 – 49195
Repeati495 – 499105
Repeati500 – 504115
Repeati508 – 512125
Repeati513 – 51713; approximate5
Repeati521 – 525145
Repeati526 – 530155
Repeati534 – 538165
Repeati539 – 543175
Repeati547 – 551185
Repeati552 – 556195
Repeati560 – 564205
Repeati565 – 569215
Repeati573 – 577225
Repeati578 – 582235
Repeati583 – 587245
Repeati591 – 595255
Repeati596 – 600265
Repeati601 – 605275
Repeati609 – 613285
Repeati614 – 618295
Repeati619 – 623305
Repeati627 – 631315
Repeati632 – 636325
Repeati637 – 641335
Repeati645 – 649345
Repeati650 – 654355
Repeati655 – 659365
Repeati663 – 667375
Repeati671 – 675385
Repeati676 – 680395
Repeati684 – 688405
Repeati689 – 693415
Repeati697 – 701425
Repeati702 – 706435
Repeati707 – 711445
Repeati715 – 719455

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni432 – 71945 X 5 AA approximate tandem repeats of [LVMGIED]-[PQSKHARMI]-[EDKLVTR]-[LIVMAP]-[AQKHRPEVSD]; that may have a tripeptide spacer of [LVIDEA]-[PMSVI]-[KEATDQ]Add BLAST288

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi70 – 84Nuclear export signalBy similarityAdd BLAST15
Motifi118 – 196Nuclear localization signalAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 196Arg/Lys-rich (basic)Add BLAST79
Compositional biasi1044 – 1171Glu-rich (acidic)Add BLAST128
Compositional biasi1287 – 1291Poly-Glu5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains.Curated
The PDZ domain contains the signal for export from the nucleus (By similarity). The N-terminal region including the PDZ domain is required for the formation of Cajal bands on myelinated nerves.By similarity1 Publication
The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the periaxin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410II3A Eukaryota
ENOG410ZMDY LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160366

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168246

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG031836

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O55103

Database of Orthologous Groups

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OrthoDBi
71329at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O55103

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O55103-1) [UniParc]FASTAAdd to basket
Also known as: L-periaxin

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEARSRSAEE LRRAELVEII VETEAQTGVS GFNVAGGGKE GIFVRELRED
60 70 80 90 100
SPAAKSLSLQ EGDQLLSARV FFENFKYEDA LRLLQCAEPY KVSFCLKRTV
110 120 130 140 150
PTGDLALRPG TVSGYEMKGP RAKVAKLNIQ SLAPVKKKKM VTGALGTPAD
160 170 180 190 200
LAPVDVEFSF PKFSRLRRGL KAEAVKGPVP AAPARRRLQL PRLRVREVAE
210 220 230 240 250
EAQVARMAAA APPPRKAKAE AEAATGAGFT APQIELVGPR LPSAEVGVPQ
260 270 280 290 300
VSVPKGTPST EAASGFALHL PTLGLGAPAA PAVEPPATGI QVPQVELPTL
310 320 330 340 350
PSLPTLPTLP CLDTQEGAAV VKVPTLDVAA PSMGVDLALP GAEVEAQGEV
360 370 380 390 400
PEVALKMPRL SFPRFGIRGK EATEAKVVKG SPEAKAKGPR LRMPTFGLSL
410 420 430 440 450
LEPRPSGPEA VAESKLKLPT LKMPSFGIGV AGPEVKAPTG PEVKLPKVPE
460 470 480 490 500
VKLPKVPEAA IPDVQLPEVQ LPKMSDMKLP KIPEMVVPDV RLPEVQLPKV
510 520 530 540 550
PEMKVPEMKL PKWPEMAVPD VHLPDVQLPK VPEMKLPKVP EMAVPDVHLP
560 570 580 590 600
DVQLPKVPEM KLPEMKLPKV PEMAVPDVRL PEVQLPKVSE VKLPKMPEMA
610 620 630 640 650
VPDVHLPELQ LPKMSEVKLP KMPEMAVPDV RLPEVQLPKV SEMKLPKMPE
660 670 680 690 700
MTMPDIRLPE VQLPKVPDIK LPEMKLPEIK LPKVPDMAVP DVPLPELQLP
710 720 730 740 750
KVSDIRLPEM QVSQVPEVQL PKMPEMKLSK VPEVQRKSAG AEQAKGTEFS
760 770 780 790 800
FKLPKMTMPK LGKVGKPGEA SIEVPDKLMT LPCLQPEVGT EASHVGVPSL
810 820 830 840 850
SLPSVELDLP GALGLEGQVQ EAVPGKVEKP EGPRVAVGVG EVGFRVPSVE
860 870 880 890 900
IVTPQLPTVE VEKEQLEMVE MKVKPSSKFS LPKFGLSGPK AVKGEVEGPG
910 920 930 940 950
RATKLKVSKF TISLPKARAG TEAEAKGAGE AGLLPALDLS IPQLSLDAQL
960 970 980 990 1000
PSGKVEVADS KPKSSRFALP KFGVKGRDSE ADVLVAGEAE LEGKGWGWDG
1010 1020 1030 1040 1050
KVKMPKLKMP SFGLSRGKEA ETQDGRVSPG EKLEAIAGQL KIPAVELVTP
1060 1070 1080 1090 1100
GAQETEKVTS GVKPSGLQVS TTGQVVAEGQ ESVQRVSTLG ISLPQVELAS
1110 1120 1130 1140 1150
FGEAGPEIVA PSAEGTAGSR VQVPQVMLEL PGTQVAGGDL LVGEGIFKMP
1160 1170 1180 1190 1200
TVTVPQLELD VGLGHEAQAG EAAKSEGGIK LKLPTLGTGS RGEGVEPQGP
1210 1220 1230 1240 1250
EAQRTFHLSL PDVELTSPVS SHAEYQVVEG DGDGGHKLKV RLPLFGLAKA
1260 1270 1280 1290 1300
KEGIEVGEKV KSPKLRLPRV GFSQSESVSG EGSPSPEEEE EGSGEGASSR
1310 1320 1330 1340 1350
RGRVRVRLPR VGLASPSKVS KGQEGDATSK SPVGEKSPKF RFPRVSLSPK
1360 1370 1380 1390
ARSGSRDREE GGFRVRLPSV GFSETAVPGS TRIEGTQAAA I
Length:1,391
Mass (Da):147,688
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB16DF4E5C33D376C
GO
Isoform 2 (identifier: O55103-2) [UniParc]FASTAAdd to basket
Also known as: S-periaxin

The sequence of this isoform differs from the canonical sequence as follows:
     128-148: NIQSLAPVKKKKMVTGALGTP → VRVLSPVPVQDSPSDRVAAAP
     149-1391: Missing.

Show »
Length:148
Mass (Da):16,124
Checksum:i426D1148993E79B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QQ57E9QQ57_MOUSE
Periaxin
Prx
1,391Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6NVF7Q6NVF7_MOUSE
Periaxin
Prx
1,391Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNK1A0A0U1RNK1_MOUSE
Periaxin
Prx
1,252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004366128 – 148NIQSL…ALGTP → VRVLSPVPVQDSPSDRVAAA P in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_004367149 – 1391Missing in isoform 2. 1 PublicationAdd BLAST1243

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ222968 mRNA Translation: CAA11022.1
AJ222969 mRNA Translation: CAA11023.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS21023.1 [O55103-1]
CCDS39849.1 [O55103-2]

NCBI Reference Sequences

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RefSeqi
NP_062285.1, NM_019412.2 [O55103-2]
NP_932165.2, NM_198048.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.10119

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000108355; ENSMUSP00000103992; ENSMUSG00000053198 [O55103-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
19153

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:19153

UCSC genome browser

More...
UCSCi
uc009fwj.2 mouse [O55103-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222968 mRNA Translation: CAA11022.1
AJ222969 mRNA Translation: CAA11023.1
CCDSiCCDS21023.1 [O55103-1]
CCDS39849.1 [O55103-2]
RefSeqiNP_062285.1, NM_019412.2 [O55103-2]
NP_932165.2, NM_198048.2
UniGeneiMm.10119

3D structure databases

ProteinModelPortaliO55103
SMRiO55103
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202408, 1 interactor
CORUMiO55103
IntActiO55103, 2 interactors
MINTiO55103
STRINGi10090.ENSMUSP00000096241

PTM databases

iPTMnetiO55103
PhosphoSitePlusiO55103

Proteomic databases

MaxQBiO55103
PaxDbiO55103
PeptideAtlasiO55103
PRIDEiO55103

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108355; ENSMUSP00000103992; ENSMUSG00000053198 [O55103-2]
GeneIDi19153
KEGGimmu:19153
UCSCiuc009fwj.2 mouse [O55103-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57716
MGIiMGI:108176 Prx

Phylogenomic databases

eggNOGiENOG410II3A Eukaryota
ENOG410ZMDY LUCA
GeneTreeiENSGT00940000160366
HOGENOMiHOG000168246
HOVERGENiHBG031836
InParanoidiO55103
OrthoDBi71329at2759
PhylomeDBiO55103

Miscellaneous databases

Protein Ontology

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PROi
PR:O55103

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000053198 Expressed in 199 organ(s), highest expression level in sciatic nerve
CleanExiMM_PRX
ExpressionAtlasiO55103 baseline and differential
GenevisibleiO55103 MM

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRAX_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O55103
Secondary accession number(s): O55104
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: January 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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