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Protein

Biogenesis of lysosome-related organelles complex 1 subunit 1

Gene

Bloc1s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:16760431, PubMed:19546860, PubMed:21998198). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).By similarity3 Publications
May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.By similarity

GO - Biological processi

  • aerobic respiration Source: UniProtKB
  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • endosomal transport Source: GO_Central
  • lysosome localization Source: UniProtKB
  • neuron projection development Source: UniProtKB
  • peptidyl-lysine acetylation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Biogenesis of lysosome-related organelles complex 1 subunit 1
Short name:
BLOC-1 subunit 1
Alternative name(s):
GCN5-like protein 1
Gene namesi
Name:Bloc1s1
Synonyms:Gcn5l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1195276 Bloc1s1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001563321 – 125Biogenesis of lysosome-related organelles complex 1 subunit 1Add BLAST125

Proteomic databases

EPDiO55102
MaxQBiO55102
PaxDbiO55102
PRIDEiO55102

PTM databases

iPTMnetiO55102
PhosphoSitePlusiO55102

Expressioni

Gene expression databases

BgeeiENSMUSG00000090247 Expressed in 19 organ(s), highest expression level in heart
ExpressionAtlasiO55102 baseline and differential
GenevisibleiO55102 MM

Interactioni

Subunit structurei

Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8 (PubMed:15102850). The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (PubMed:21998198). Interacts with ATP5F1A and NDUFA9; involved in their acetylation on lysine residues (By similarity). Interacts with KXD1 (PubMed:22554196).By similarity3 Publications

Protein-protein interaction databases

ComplexPortaliCPX-1913 BLOC-1 complex
CORUMiO55102
STRINGi10090.ENSMUSP00000026405

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 31Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the BLOC1S1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3390 Eukaryota
ENOG4111NES LUCA
GeneTreeiENSGT00390000002689
HOGENOMiHOG000005725
HOVERGENiHBG050694
InParanoidiO55102
KOiK20185
OMAiQWISMVE
OrthoDBiEOG091G0V8A
PhylomeDBiO55102
TreeFamiTF314443

Family and domain databases

InterProiView protein in InterPro
IPR009395 BLOC1S1
PANTHERiPTHR13073 PTHR13073, 1 hit
PfamiView protein in Pfam
PF06320 GCN5L1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O55102-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSRLLKEHQ AKQNERKELQ EKRRREAIAA ATCLTEALVD HLNVGVAQAY
60 70 80 90 100
MNQRKLDHEV KTLQVQAAQF AKQTGQWIGM VENFNQALKE IGDVENWARS
110 120
IELDMRTIAT ALEYVYKGQL QSAPS
Length:125
Mass (Da):14,281
Last modified:January 4, 2005 - v2
Checksum:i754897B17BC9479D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4L7D3Z4L7_MOUSE
Biogenesis of lysosome-related orga...
Bloc1s1
94Annotation score:
D3YVM8D3YVM8_MOUSE
Biogenesis of lysosome-related orga...
Bloc1s1
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → Y in CAA74108 (PubMed:9426003).Curated1
Sequence conflicti35T → I in CAA74108 (PubMed:9426003).Curated1
Sequence conflicti40D → V in CAA74108 (PubMed:9426003).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13778
, Y13779, Y13780, Y13781 Genomic DNA Translation: CAA74108.1
AK003035 mRNA Translation: BAB22523.1
BC034662 mRNA Translation: AAH34662.1
CCDSiCCDS24299.1
PIRiJC6514
RefSeqiNP_056555.2, NM_015740.3
XP_006513292.1, XM_006513229.3
UniGeneiMm.30118

Genome annotation databases

EnsembliENSMUST00000026405; ENSMUSP00000026405; ENSMUSG00000090247
GeneIDi14533
KEGGimmu:14533
UCSCiuc007hoz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13778
, Y13779, Y13780, Y13781 Genomic DNA Translation: CAA74108.1
AK003035 mRNA Translation: BAB22523.1
BC034662 mRNA Translation: AAH34662.1
CCDSiCCDS24299.1
PIRiJC6514
RefSeqiNP_056555.2, NM_015740.3
XP_006513292.1, XM_006513229.3
UniGeneiMm.30118

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1913 BLOC-1 complex
CORUMiO55102
STRINGi10090.ENSMUSP00000026405

PTM databases

iPTMnetiO55102
PhosphoSitePlusiO55102

Proteomic databases

EPDiO55102
MaxQBiO55102
PaxDbiO55102
PRIDEiO55102

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026405; ENSMUSP00000026405; ENSMUSG00000090247
GeneIDi14533
KEGGimmu:14533
UCSCiuc007hoz.1 mouse

Organism-specific databases

CTDi2647
MGIiMGI:1195276 Bloc1s1

Phylogenomic databases

eggNOGiKOG3390 Eukaryota
ENOG4111NES LUCA
GeneTreeiENSGT00390000002689
HOGENOMiHOG000005725
HOVERGENiHBG050694
InParanoidiO55102
KOiK20185
OMAiQWISMVE
OrthoDBiEOG091G0V8A
PhylomeDBiO55102
TreeFamiTF314443

Enzyme and pathway databases

ReactomeiR-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

PROiPR:O55102
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090247 Expressed in 19 organ(s), highest expression level in heart
ExpressionAtlasiO55102 baseline and differential
GenevisibleiO55102 MM

Family and domain databases

InterProiView protein in InterPro
IPR009395 BLOC1S1
PANTHERiPTHR13073 PTHR13073, 1 hit
PfamiView protein in Pfam
PF06320 GCN5L1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBL1S1_MOUSE
AccessioniPrimary (citable) accession number: O55102
Secondary accession number(s): Q9DC96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 4, 2005
Last modified: September 12, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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