Akap7

Functionⁱ

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

AMP binding Source: MGI
protein-containing complex scaffold activity Source: MGI
protein C-terminus binding Source: MGI
protein domain specific binding Source: MGI
protein kinase A binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 9545239
protein kinase A regulatory subunit binding Source: MGI
protein kinase binding
Source: MGI
Inferred from direct assayⁱ
- 12804576

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to cAMP Source: MGI
modulation of chemical synaptic transmission
Source: SynGO
Inferred from direct assayⁱ
- 27911261
positive regulation of delayed rectifier potassium channel activity Source: MGI
positive regulation of potassium ion transmembrane transport Source: MGI
protein localization
Source: MGI
Inferred from sequence orthologyⁱ
- 9545239
regulation of membrane repolarization Source: MGI
regulation of protein kinase A signaling Source: MGI
transmembrane receptor protein serine/threonine kinase signaling pathway
Source: MGI
Inferred from sequence orthologyⁱ
- 9545239

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: A-kinase anchor protein 7 isoform alpha Short name: AKAP-7 isoform alpha Alternative name(s): A-kinase anchor protein 18 Short name: AKAP-18 A-kinase anchor protein 9 kDa Short name: AKAP 9 Protein kinase A-anchoring protein 7 isoform alpha Short name: PRKA7 isoform alpha
Gene namesⁱ	Name:Akap7 Synonyms:Akap18
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1859150 Akap7

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000064532	2 – 81	A-kinase anchor protein 7 isoform alphaAdd BLAST		80

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication	1
Lipidationⁱ	5	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	6	S-palmitoyl cysteine1 Publication	1

Keywords - PTMⁱ

Lipoprotein, Myristate, Palmitate

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	O55074
PRIDEⁱ	O55074

PTM databases

iPTMnetⁱ	O55074
PhosphoSitePlusⁱ	O55074
SwissPalmⁱ	O55074

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000039166 Expressed in 234 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_AKAP7
ExpressionAtlasⁱ	O55074 baseline and differential
Genevisibleⁱ	O55074 MM

Interactionⁱ

Subunit structureⁱ

Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA (By similarity).By similarity

GO - Molecular functionⁱ

protein-containing complex scaffold activity Source: MGI
protein C-terminus binding Source: MGI
protein domain specific binding Source: MGI
protein kinase A binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 9545239
protein kinase A regulatory subunit binding Source: MGI
protein kinase binding
Source: MGI
Inferred from direct assayⁱ
- 12804576

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	240608, 1 interactor

BioGridⁱ

240608, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O55074
SMRⁱ	O55074
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 11	Required for membrane localizationBy similarity		10
Regionⁱ	29 – 42	RII-bindingBy similarityAdd BLAST		14

Phylogenomic databases

eggNOGⁱ	KOG2814 Eukaryota ENOG4111FMP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012756
HOGENOMⁱ	HOG000013043
HOVERGENⁱ	HBG050474
KEGG Orthology (KO) More...KOⁱ	K16524

Family and domain databases

InterProⁱ	View protein in InterPro IPR019511 AKAP7_RI-RII-bd_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10470 AKAP7_RIRII_bdg, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform Alpha (identifier: O55074-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQLCCFPFA RDEGKICEKD RREPEDAELV RLSKRLVENA VLKAVQQYLE 
        60         70         80 
ETQNKKQPGE GNSTKAEEGD RNGDGSDNNR K

Length:81

Mass (Da):9,169

Last modified:October 3, 2012 - v4

Checksum:ⁱ2297FA55FE35AC9E

GO

Isoform Gamma (identifier: Q7TN79-1) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q7TN79.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:314

Mass (Da):35,482

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12	D → E in AAC40085 (PubMed:9545239).Curated	1
Sequence conflictⁱ	22	R → K in AAC40085 (PubMed:9545239).Curated	1
Sequence conflictⁱ	64	T → V in AAC40085 (PubMed:9545239).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF047716 mRNA Translation: AAC40085.1 AC153549 Genomic DNA No translation available. AC153550 Genomic DNA No translation available. CH466540 Genomic DNA Translation: EDL04795.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS83688.1 [O55074-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001334389.1, NM_001347460.1 [O55074-1]
UniGeneⁱ	Mm.485937 Mm.487103

Genome annotation databases

Ensemblⁱ	ENSMUST00000100012; ENSMUSP00000097590; ENSMUSG00000039166 [O55074-1]
GeneIDⁱ	432442
KEGGⁱ	mmu:432442
UCSC genome browser More...UCSCⁱ	uc007erh.1 mouse [O55074-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O55074	A-kinase anchor protein 7 isoform gamma isoform X6		MESAU		81	UniRef90_O55074
Protein kinase A anchor protein, RI-RII subunit-binding domain containing protein		CRIGR		81
UPI00038C3E0D		MICOH		81
UPI00077DBB5B		PERMB		81
UPI000B4F4DF0		MERUN		81

Protein	Similar proteins		Species	Score	Length	Source
O55074	A-kinase anchor protein 7 isoform gamma isoform X6		MESAU		81	UniRef50_O55074
Protein kinase A anchor protein, RI-RII subunit-binding domain containing protein		CRIGR		81
Uncharacterized protein		MANLE		81
Uncharacterized protein		PROCO		81
A-kinase anchoring protein 7		SAIBB		81
+60

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF047716 mRNA Translation: AAC40085.1 AC153549 Genomic DNA No translation available. AC153550 Genomic DNA No translation available. CH466540 Genomic DNA Translation: EDL04795.1
CCDSⁱ	CCDS83688.1 [O55074-1]
RefSeqⁱ	NP_001334389.1, NM_001347460.1 [O55074-1]
UniGeneⁱ	Mm.485937 Mm.487103

3D structure databases

ProteinModelPortalⁱ	O55074
SMRⁱ	O55074
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	240608, 1 interactor

BioGridⁱ

240608, 1 interactor

PTM databases

iPTMnetⁱ	O55074
PhosphoSitePlusⁱ	O55074
SwissPalmⁱ	O55074

Proteomic databases

PeptideAtlasⁱ	O55074
PRIDEⁱ	O55074

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000100012; ENSMUSP00000097590; ENSMUSG00000039166 [O55074-1]
GeneIDⁱ	432442
KEGGⁱ	mmu:432442
UCSCⁱ	uc007erh.1 mouse [O55074-1]

Organism-specific databases

CTDⁱ	9465
MGIⁱ	MGI:1859150 Akap7

Phylogenomic databases

eggNOGⁱ	KOG2814 Eukaryota ENOG4111FMP LUCA
GeneTreeⁱ	ENSGT00390000012756
HOGENOMⁱ	HOG000013043
HOVERGENⁱ	HBG050474
KOⁱ	K16524

Miscellaneous databases

ChiTaRSⁱ	Akap7 mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039166 Expressed in 234 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_AKAP7
ExpressionAtlasⁱ	O55074 baseline and differential
Genevisibleⁱ	O55074 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR019511 AKAP7_RI-RII-bd_dom
Pfamⁱ	View protein in Pfam PF10470 AKAP7_RIRII_bdg, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AKA7A_MOUSE
Accessionⁱ	O55074Primary (citable) accession number: O55074 Secondary accession number(s): G3X9Q5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	October 3, 2012
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O55074 (AKA7A_MOUSE)

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A-kinase anchor protein 7 isoform alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Endoplasmic reticulum

Nucleus

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ