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Protein

A-kinase anchor protein 7 isoform alpha

Gene

Akap7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 7 isoform alpha
Short name:
AKAP-7 isoform alpha
Alternative name(s):
A-kinase anchor protein 18
Short name:
AKAP-18
A-kinase anchor protein 9 kDa
Short name:
AKAP 9
Protein kinase A-anchoring protein 7 isoform alpha
Short name:
PRKA7 isoform alpha
Gene namesi
Name:Akap7
Synonyms:Akap18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1859150 Akap7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000645322 – 81A-kinase anchor protein 7 isoform alphaAdd BLAST80

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi5S-palmitoyl cysteine1 Publication1
Lipidationi6S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PeptideAtlasiO55074
PRIDEiO55074

PTM databases

iPTMnetiO55074
PhosphoSitePlusiO55074
SwissPalmiO55074

Expressioni

Gene expression databases

BgeeiENSMUSG00000039166 Expressed in 234 organ(s), highest expression level in cerebral cortex
CleanExiMM_AKAP7
ExpressionAtlasiO55074 baseline and differential
GenevisibleiO55074 MM

Interactioni

Subunit structurei

Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi240608, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO55074
SMRiO55074
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 11Required for membrane localizationBy similarity10
Regioni29 – 42RII-bindingBy similarityAdd BLAST14

Phylogenomic databases

eggNOGiKOG2814 Eukaryota
ENOG4111FMP LUCA
GeneTreeiENSGT00390000012756
HOGENOMiHOG000013043
HOVERGENiHBG050474
KOiK16524

Family and domain databases

InterProiView protein in InterPro
IPR019511 AKAP7_RI-RII-bd_dom
PfamiView protein in Pfam
PF10470 AKAP7_RIRII_bdg, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Alpha (identifier: O55074-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQLCCFPFA RDEGKICEKD RREPEDAELV RLSKRLVENA VLKAVQQYLE
60 70 80
ETQNKKQPGE GNSTKAEEGD RNGDGSDNNR K
Length:81
Mass (Da):9,169
Last modified:October 3, 2012 - v4
Checksum:i2297FA55FE35AC9E
GO
Isoform Gamma (identifier: Q7TN79-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q7TN79.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:314
Mass (Da):35,482
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12D → E in AAC40085 (PubMed:9545239).Curated1
Sequence conflicti22R → K in AAC40085 (PubMed:9545239).Curated1
Sequence conflicti64T → V in AAC40085 (PubMed:9545239).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047716 mRNA Translation: AAC40085.1
AC153549 Genomic DNA No translation available.
AC153550 Genomic DNA No translation available.
CH466540 Genomic DNA Translation: EDL04795.1
CCDSiCCDS83688.1 [O55074-1]
RefSeqiNP_001334389.1, NM_001347460.1 [O55074-1]
UniGeneiMm.485937
Mm.487103

Genome annotation databases

EnsembliENSMUST00000100012; ENSMUSP00000097590; ENSMUSG00000039166 [O55074-1]
GeneIDi432442
KEGGimmu:432442
UCSCiuc007erh.1 mouse [O55074-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047716 mRNA Translation: AAC40085.1
AC153549 Genomic DNA No translation available.
AC153550 Genomic DNA No translation available.
CH466540 Genomic DNA Translation: EDL04795.1
CCDSiCCDS83688.1 [O55074-1]
RefSeqiNP_001334389.1, NM_001347460.1 [O55074-1]
UniGeneiMm.485937
Mm.487103

3D structure databases

ProteinModelPortaliO55074
SMRiO55074
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi240608, 1 interactor

PTM databases

iPTMnetiO55074
PhosphoSitePlusiO55074
SwissPalmiO55074

Proteomic databases

PeptideAtlasiO55074
PRIDEiO55074

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100012; ENSMUSP00000097590; ENSMUSG00000039166 [O55074-1]
GeneIDi432442
KEGGimmu:432442
UCSCiuc007erh.1 mouse [O55074-1]

Organism-specific databases

CTDi9465
MGIiMGI:1859150 Akap7

Phylogenomic databases

eggNOGiKOG2814 Eukaryota
ENOG4111FMP LUCA
GeneTreeiENSGT00390000012756
HOGENOMiHOG000013043
HOVERGENiHBG050474
KOiK16524

Miscellaneous databases

ChiTaRSiAkap7 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039166 Expressed in 234 organ(s), highest expression level in cerebral cortex
CleanExiMM_AKAP7
ExpressionAtlasiO55074 baseline and differential
GenevisibleiO55074 MM

Family and domain databases

InterProiView protein in InterPro
IPR019511 AKAP7_RI-RII-bd_dom
PfamiView protein in Pfam
PF10470 AKAP7_RIRII_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKA7A_MOUSE
AccessioniPrimary (citable) accession number: O55074
Secondary accession number(s): G3X9Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 127 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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