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Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Gene

Pde6d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.By similarity3 Publications

GO - Molecular functioni

  • 3',5'-cyclic-GMP phosphodiesterase activity Source: MGI
  • GTPase inhibitor activity Source: UniProtKB
  • Rab GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision
LigandcGMP

Enzyme and pathway databases

ReactomeiR-MMU-5624958 ARL13B-mediated ciliary trafficking of INPP5E

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Short name:
GMP-PDE delta
Gene namesi
Name:Pde6d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1270843 Pde6d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002212091 – 150Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaAdd BLAST150

Proteomic databases

PaxDbiO55057
PeptideAtlasiO55057
PRIDEiO55057

PTM databases

PhosphoSitePlusiO55057

Expressioni

Gene expression databases

BgeeiENSMUSG00000026239 Expressed in 300 organ(s), highest expression level in olfactory epithelium
CleanExiMM_PDE6D
ExpressionAtlasiO55057 baseline and differential
GenevisibleiO55057 MM

Interactioni

Subunit structurei

Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains (PDE6A and PDE6B) and two inhibitory chains (gamma); has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane (By similarity). Interacts with prenylated GRK1 and GRK7 (By similarity). Interacts with prenylated INPP5E (By similarity). Interacts with prenylated Ras family members, including HRAS, KRAS, NRAS, RAP2A, RAP2C and RHEB (PubMed:22179043). Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes (By similarity). Interacts with RPGR (PubMed:9990021). Interacts with ARL2 (PubMed:15979089). Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (PubMed:15979089). Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins (By similarity).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202080, 1 interactor
CORUMiO55057
IntActiO55057, 1 interactor
STRINGi10090.ENSMUSP00000027444

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO55057
SMRiO55057
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 150Required for association with membranesBy similarity7

Sequence similaritiesi

Belongs to the PDE6D/unc-119 family.Curated

Phylogenomic databases

eggNOGiKOG4038 Eukaryota
ENOG4110ZMQ LUCA
GeneTreeiENSGT00390000000263
HOGENOMiHOG000007689
HOVERGENiHBG053542
InParanoidiO55057
KOiK13758
OMAiSTNTWQN
OrthoDBiEOG091G0SV1
PhylomeDBiO55057
TreeFamiTF314474

Family and domain databases

Gene3Di2.70.50.40, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR008015 PDED_dom
IPR037036 PDED_dom_sf
IPR017287 Rhodop-sen_GMP-Pdiesterase_dsu
PANTHERiPTHR12976 PTHR12976, 1 hit
PfamiView protein in Pfam
PF05351 GMP_PDE_delta, 1 hit
PIRSFiPIRSF037825 GMP-Pdiesterase_delta, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O55057-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKDERARD ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP
60 70 80 90 100
KKILKCKAVS RELNFSSAEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN
110 120 130 140 150
STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSKVRLFYV
Length:150
Mass (Da):17,348
Last modified:June 1, 1998 - v1
Checksum:i5E8D89C8020E38D5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QWG6M0QWG6_MOUSE
Retinal rod rhodopsin-sensitive cGM...
Pde6d
124Annotation score:
M0QWR1M0QWR1_MOUSE
Retinal rod rhodopsin-sensitive cGM...
Pde6d
70Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046000 Genomic DNA Translation: AAC40094.1
AF039216 mRNA Translation: AAC25686.1
BC005636 mRNA Translation: AAH05636.1
CCDSiCCDS15121.1
RefSeqiNP_032827.1, NM_008801.2
UniGeneiMm.12925

Genome annotation databases

EnsembliENSMUST00000027444; ENSMUSP00000027444; ENSMUSG00000026239
GeneIDi18582
KEGGimmu:18582
UCSCiuc007bvq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046000 Genomic DNA Translation: AAC40094.1
AF039216 mRNA Translation: AAC25686.1
BC005636 mRNA Translation: AAH05636.1
CCDSiCCDS15121.1
RefSeqiNP_032827.1, NM_008801.2
UniGeneiMm.12925

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T4XX-ray1.81A1-150[»]
ProteinModelPortaliO55057
SMRiO55057
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202080, 1 interactor
CORUMiO55057
IntActiO55057, 1 interactor
STRINGi10090.ENSMUSP00000027444

PTM databases

PhosphoSitePlusiO55057

Proteomic databases

PaxDbiO55057
PeptideAtlasiO55057
PRIDEiO55057

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027444; ENSMUSP00000027444; ENSMUSG00000026239
GeneIDi18582
KEGGimmu:18582
UCSCiuc007bvq.1 mouse

Organism-specific databases

CTDi5147
MGIiMGI:1270843 Pde6d

Phylogenomic databases

eggNOGiKOG4038 Eukaryota
ENOG4110ZMQ LUCA
GeneTreeiENSGT00390000000263
HOGENOMiHOG000007689
HOVERGENiHBG053542
InParanoidiO55057
KOiK13758
OMAiSTNTWQN
OrthoDBiEOG091G0SV1
PhylomeDBiO55057
TreeFamiTF314474

Enzyme and pathway databases

ReactomeiR-MMU-5624958 ARL13B-mediated ciliary trafficking of INPP5E

Miscellaneous databases

PROiPR:O55057
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026239 Expressed in 300 organ(s), highest expression level in olfactory epithelium
CleanExiMM_PDE6D
ExpressionAtlasiO55057 baseline and differential
GenevisibleiO55057 MM

Family and domain databases

Gene3Di2.70.50.40, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR008015 PDED_dom
IPR037036 PDED_dom_sf
IPR017287 Rhodop-sen_GMP-Pdiesterase_dsu
PANTHERiPTHR12976 PTHR12976, 1 hit
PfamiView protein in Pfam
PF05351 GMP_PDE_delta, 1 hit
PIRSFiPIRSF037825 GMP-Pdiesterase_delta, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDE6D_MOUSE
AccessioniPrimary (citable) accession number: O55057
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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