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Protein

tRNA (cytosine(38)-C(5))-methyltransferase

Gene

Trdmt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).By similarity

Catalytic activityi

S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34S-adenosyl-L-methionineBy similarity1
Binding sitei76S-adenosyl-L-methionineBy similarity1
Active sitei79PROSITE-ProRule annotation1
Binding sitei376S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

  • RNA binding Source: UniProtKB-KW
  • tRNA (cytosine-5-)-methyltransferase activity Source: MGI
  • tRNA methyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.37 3474

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (cytosine(38)-C(5))-methyltransferase (EC:2.1.1.204)
Alternative name(s):
DNA (cytosine-5)-methyltransferase-like protein 2
Short name:
Dnmt2
DNA methyltransferase homolog MmuIIP
Short name:
DNA MTase homolog MmuIIP
Short name:
M.MmuIIP
Met-2
Gene namesi
Name:Trdmt1
Synonyms:Dnmt2, Met2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1274787 Trdmt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000880411 – 415tRNA (cytosine(38)-C(5))-methyltransferaseAdd BLAST415

Proteomic databases

PaxDbiO55055
PRIDEiO55055

PTM databases

iPTMnetiO55055
PhosphoSitePlusiO55055

Expressioni

Tissue specificityi

Highly expressed in thymus, testis, and at much lower levels in spleen, lung, brain, heart, kidney, liver, skeletal muscle and embryonic stem cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000026723 Expressed in 236 organ(s), highest expression level in cochlea
CleanExiMM_TRDMT1
ExpressionAtlasiO55055 baseline and differential
GenevisibleiO55055 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114572

Structurei

3D structure databases

ProteinModelPortaliO55055
SMRiO55055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 396SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST393

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 15S-adenosyl-L-methionine bindingBy similarity3
Regioni57 – 58S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0919 Eukaryota
COG0270 LUCA
GeneTreeiENSGT00390000016416
HOGENOMiHOG000265038
HOVERGENiHBG051385
InParanoidiO55055
KOiK15336
OMAiRLMSFPE
OrthoDBiEOG091G0FXV
PhylomeDBiO55055
TreeFamiTF300024

Family and domain databases

InterProiView protein in InterPro
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O55055-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLRVLELY SGIGGMHHAL RESHIPAHVV AAIDVNTVAN EVYKHNFPHT
60 70 80 90 100
HLLSKTIEGI SLEDFDKLSF NMILMSPPCQ PFTRIGLQGD MTDPRTTSFL
110 120 130 140 150
YILDILPRLQ KLPKYILLEN VKGFEVSSTR GLLIQTIEAC GFQYQEFLLS
160 170 180 190 200
PSSLGIPNSR LRYFLIAKLQ SEPFPFQAPG QILMEFPKIV TVEPQKYAVV
210 220 230 240 250
EESQPRVQRT GPRICAESSS TQSSGKDTIL FKLETVEERD RKHQQDSDLS
260 270 280 290 300
VQMLKDFLED GDTDEYLLPP KLLLRYALLL DIVKPTSRRS MCFTKGYGSY
310 320 330 340 350
IEGTGSVLQA AEDAQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN
360 370 380 390 400
LQGFPPEFGF PEKTTVKQRY RLLGNSLNVH VVAKLLTVLC EGFGNASESC
410
HKMPLILDSN SKILS
Length:415
Mass (Da):46,794
Last modified:February 21, 2002 - v2
Checksum:i14FEF78C0D2F8BFB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWY7A0A0A6YWY7_MOUSE
tRNA (cytosine(38)-C(5))-methyltran...
Trdmt1
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164F → S in AAC40130 (PubMed:9592134).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012129 mRNA Translation: AAC53529.1
AF045889 mRNA Translation: AAC40130.1
CCDSiCCDS15695.1
RefSeqiNP_034197.3, NM_010067.4
UniGeneiMm.6979

Genome annotation databases

EnsembliENSMUST00000124488; ENSMUSP00000114572; ENSMUSG00000026723
GeneIDi13434
KEGGimmu:13434
UCSCiuc008ika.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012129 mRNA Translation: AAC53529.1
AF045889 mRNA Translation: AAC40130.1
CCDSiCCDS15695.1
RefSeqiNP_034197.3, NM_010067.4
UniGeneiMm.6979

3D structure databases

ProteinModelPortaliO55055
SMRiO55055
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114572

PTM databases

iPTMnetiO55055
PhosphoSitePlusiO55055

Proteomic databases

PaxDbiO55055
PRIDEiO55055

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124488; ENSMUSP00000114572; ENSMUSG00000026723
GeneIDi13434
KEGGimmu:13434
UCSCiuc008ika.2 mouse

Organism-specific databases

CTDi1787
MGIiMGI:1274787 Trdmt1

Phylogenomic databases

eggNOGiKOG0919 Eukaryota
COG0270 LUCA
GeneTreeiENSGT00390000016416
HOGENOMiHOG000265038
HOVERGENiHBG051385
InParanoidiO55055
KOiK15336
OMAiRLMSFPE
OrthoDBiEOG091G0FXV
PhylomeDBiO55055
TreeFamiTF300024

Enzyme and pathway databases

BRENDAi2.1.1.37 3474

Miscellaneous databases

PROiPR:O55055
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026723 Expressed in 236 organ(s), highest expression level in cochlea
CleanExiMM_TRDMT1
ExpressionAtlasiO55055 baseline and differential
GenevisibleiO55055 MM

Family and domain databases

InterProiView protein in InterPro
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRDMT_MOUSE
AccessioniPrimary (citable) accession number: O55055
Secondary accession number(s): O35212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 21, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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