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Protein

Alpha-synuclein

Gene

Snca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of dopamine release and transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2CopperBy similarity1
Metal bindingi50CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synuclein
Alternative name(s):
Non-A beta component of AD amyloid
Non-A4 component of amyloid precursor
Short name:
NACP
Gene namesi
Name:Snca
Synonyms:Syn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1277151 Snca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840261 – 140Alpha-synucleinAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei125Phosphotyrosine; by FYNBy similarity1
Modified residuei129Phosphoserine; by PLK21 Publication1

Post-translational modificationi

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress (By similarity).By similarity
Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).By similarity
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO55042
PaxDbiO55042
PeptideAtlasiO55042
PRIDEiO55042

PTM databases

iPTMnetiO55042
PhosphoSitePlusiO55042

Miscellaneous databases

PMAP-CutDBiO55042

Expressioni

Gene expression databases

BgeeiENSMUSG00000025889 Expressed in 260 organ(s), highest expression level in blood
CleanExiMM_SNCA
GenevisibleiO55042 MM

Interactioni

Subunit structurei

Interacts with UCHL1.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203365, 16 interactors
IntActiO55042, 8 interactors
MINTiO55042
STRINGi10090.ENSMUSP00000109907

Structurei

3D structure databases

ProteinModelPortaliO55042
SMRiO55042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWI2 Eukaryota
ENOG4111TDZ LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiO55042
KOiK04528
OMAiSEAYEMP
OrthoDBiEOG091G11PA
PhylomeDBiO55042
TreeFamiTF332776

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002460 Synuclein_alpha
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF5 PTHR13820:SF5, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01212 ASYNUCLEIN
PR01211 SYNUCLEIN

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O55042-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM
110 120 130 140
GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
Length:140
Mass (Da):14,485
Last modified:April 27, 2001 - v2
Checksum:i1FFD19D7E15E636C
GO
Isoform 2 (identifier: O55042-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-121: GEEGYPQEGILEDMPVDPG → VWLPVLCSVITLDTMSLHA
     122-140: Missing.

Note: No experimental confirmation available.
Show »
Length:121
Mass (Da):12,345
Checksum:i03CAFC4944C78D63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58K → T in AAC00521 (PubMed:9648883).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025018103 – 121GEEGY…PVDPG → VWLPVLCSVITLDTMSLHA in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_025019122 – 140Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044672 mRNA Translation: AAC00521.1
AF033261 mRNA Translation: AAD11254.1
AF179273 mRNA Translation: AAD56908.1
AF179272
, AF179268, AF179269, AF179270, AF179271 Genomic DNA Translation: AAD56907.1
AF163865 Genomic DNA Translation: AAG30304.1
AK014472 mRNA Translation: BAB29375.1
AK156316 mRNA Translation: BAE33670.1
BC046764 mRNA Translation: AAH46764.1
AF277451 Genomic DNA Translation: AAG44833.1
CCDSiCCDS20201.1 [O55042-1]
RefSeqiNP_001035916.1, NM_001042451.2 [O55042-1]
NP_033247.1, NM_009221.2 [O55042-1]
UniGeneiMm.17484

Genome annotation databases

EnsembliENSMUST00000114268; ENSMUSP00000109907; ENSMUSG00000025889 [O55042-1]
ENSMUST00000163779; ENSMUSP00000126067; ENSMUSG00000025889 [O55042-1]
GeneIDi20617
KEGGimmu:20617
UCSCiuc009cdn.2 mouse [O55042-1]
uc009cdp.2 mouse [O55042-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044672 mRNA Translation: AAC00521.1
AF033261 mRNA Translation: AAD11254.1
AF179273 mRNA Translation: AAD56908.1
AF179272
, AF179268, AF179269, AF179270, AF179271 Genomic DNA Translation: AAD56907.1
AF163865 Genomic DNA Translation: AAG30304.1
AK014472 mRNA Translation: BAB29375.1
AK156316 mRNA Translation: BAE33670.1
BC046764 mRNA Translation: AAH46764.1
AF277451 Genomic DNA Translation: AAG44833.1
CCDSiCCDS20201.1 [O55042-1]
RefSeqiNP_001035916.1, NM_001042451.2 [O55042-1]
NP_033247.1, NM_009221.2 [O55042-1]
UniGeneiMm.17484

3D structure databases

ProteinModelPortaliO55042
SMRiO55042
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203365, 16 interactors
IntActiO55042, 8 interactors
MINTiO55042
STRINGi10090.ENSMUSP00000109907

PTM databases

iPTMnetiO55042
PhosphoSitePlusiO55042

Proteomic databases

MaxQBiO55042
PaxDbiO55042
PeptideAtlasiO55042
PRIDEiO55042

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114268; ENSMUSP00000109907; ENSMUSG00000025889 [O55042-1]
ENSMUST00000163779; ENSMUSP00000126067; ENSMUSG00000025889 [O55042-1]
GeneIDi20617
KEGGimmu:20617
UCSCiuc009cdn.2 mouse [O55042-1]
uc009cdp.2 mouse [O55042-2]

Organism-specific databases

CTDi6622
MGIiMGI:1277151 Snca

Phylogenomic databases

eggNOGiENOG410IWI2 Eukaryota
ENOG4111TDZ LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiO55042
KOiK04528
OMAiSEAYEMP
OrthoDBiEOG091G11PA
PhylomeDBiO55042
TreeFamiTF332776

Miscellaneous databases

ChiTaRSiSyp mouse
PMAP-CutDBiO55042
PROiPR:O55042
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025889 Expressed in 260 organ(s), highest expression level in blood
CleanExiMM_SNCA
GenevisibleiO55042 MM

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002460 Synuclein_alpha
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF5 PTHR13820:SF5, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01212 ASYNUCLEIN
PR01211 SYNUCLEIN
ProtoNetiSearch...

Entry informationi

Entry nameiSYUA_MOUSE
AccessioniPrimary (citable) accession number: O55042
Secondary accession number(s): Q3U130
, Q9CXF8, Q9EQC3, Q9QUR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: September 12, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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