Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuromedin-U receptor 1

Gene

Nmur1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

GO - Molecular functioni

  • neuromedin U binding Source: MGI
  • neuromedin U receptor activity Source: MGI
  • neuropeptide receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 1
Short name:
NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene namesi
Name:Nmur1
Synonyms:Gpr66
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1341898 Nmur1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59ExtracellularSequence analysisAdd BLAST59
Transmembranei60 – 80Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 137ExtracellularSequence analysisAdd BLAST20
Transmembranei138 – 158Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini159 – 181CytoplasmicSequence analysisAdd BLAST23
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 235ExtracellularSequence analysisAdd BLAST33
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 294CytoplasmicSequence analysisAdd BLAST38
Transmembranei295 – 315Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini316 – 339ExtracellularSequence analysisAdd BLAST24
Transmembranei340 – 360Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini361 – 428CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3351216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699071 – 428Neuromedin-U receptor 1Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55040
PRIDEiO55040

PTM databases

iPTMnetiO55040
PhosphoSitePlusiO55040

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000026237
CleanExiMM_NMUR1
ExpressionAtlasiO55040 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027440

Chemistry databases

BindingDBiO55040

Structurei

3D structure databases

ProteinModelPortaliO55040
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiO55040
KOiK05052
OMAiHKAMRTP
OrthoDBiEOG091G0ZDG
TreeFamiTF318522

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005391 NeuromedU_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01566 NEUROMEDNU1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O55040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPCLNCSI FPGALSPNAS RSPLVCNISE FKWPYQPEDL NLTDEALRLK
60 70 80 90 100
YLGPQQMKQF VPICVTYLLI FVVGTLGNGL TCTVILRNKT MRTPTNFYLF
110 120 130 140 150
SLAVSDMLVL LVGLPLELYE MQQNYPFQLG ASACYFRILL LETVCLASVL
160 170 180 190 200
NVTALSVERY VAVVRPLQAK SVMTRAHVRR MVGAIWVLAT LFSLPNTSLH
210 220 230 240 250
GLSQLTVPCR GPVPDSAICS LVGPMDFYKL VVLTTALLFF CLPMVTISVL
260 270 280 290 300
YLLIGLRLRR ERMLLQVEVK GRKTAATQET SHRRIQLQDR GRRQVTKMLF
310 320 330 340 350
ALVVVFGICW APFHADRIMW SLVYGHSTEG LHLAYQCVHI ASGIFFYLGS
360 370 380 390 400
AANPVLYSLM STRFRETFLQ ALGLGTQCCH RRQPYHGSHN HIRLTTGSTL
410 420
CDVGHRNSRD EPLAVNEDPG CQQETDPS
Length:428
Mass (Da):47,934
Last modified:March 16, 2016 - v2
Checksum:iBB5BD67BCAA1E264
GO

Sequence cautioni

The sequence AAI20823 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI37776 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EDL40217 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102609 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL40217.1 Sequence problems.
BC120822 mRNA Translation: AAI20823.1 Different initiation.
BC137775 mRNA Translation: AAI37776.1 Different initiation.
AF044602 mRNA Translation: AAC02681.1
CCDSiCCDS15119.2
RefSeqiNP_001306156.1, NM_001319227.1
NP_034471.1, NM_010341.1
UniGeneiMm.389159

Genome annotation databases

EnsembliENSMUST00000212058; ENSMUSP00000148767; ENSMUSG00000026237
GeneIDi14767
KEGGimmu:14767
UCSCiuc007bvn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNMUR1_MOUSE
AccessioniPrimary (citable) accession number: O55040
Secondary accession number(s): G5E871, Q0VB23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 16, 2016
Last modified: June 20, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health