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Protein

C-X-C motif chemokine 13

Gene

Cxcl13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:Cxcl13
Synonyms:Blc, Scyb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1888499 Cxcl13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000511422 – 109C-X-C motif chemokine 13Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 59By similarity
Disulfide bondi34 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO55038
PRIDEiO55038

PTM databases

iPTMnetiO55038
PhosphoSitePlusiO55038

Expressioni

Tissue specificityi

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Gene expression databases

BgeeiENSMUSG00000023078 Expressed in 153 organ(s), highest expression level in spleen
CleanExiMM_CXCL13
ExpressionAtlasiO55038 baseline and differential
GenevisibleiO55038 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-57395N
IntActiO55038, 4 interactors
MINTiO55038
STRINGi10090.ENSMUSP00000023840

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO55038
SMRiO55038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEN1 Eukaryota
ENOG4111E5H LUCA
GeneTreeiENSGT00530000064292
HOGENOMiHOG000220915
HOVERGENiHBG098474
InParanoidiO55038
KOiK10032
OMAiGCPNTEI
OrthoDBiEOG091G0XS0
PhylomeDBiO55038
TreeFamiTF335204

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI
60 70 80 90 100
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ

APVSKRRAA
Length:109
Mass (Da):11,927
Last modified:June 1, 1998 - v1
Checksum:iF5F8AF4411C56BD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044196 mRNA Translation: AAC14401.1
BC012965 mRNA Translation: AAH12965.1
CCDSiCCDS19447.1
RefSeqiNP_061354.1, NM_018866.2
UniGeneiMm.10116

Genome annotation databases

EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078
GeneIDi55985
KEGGimmu:55985
UCSCiuc008yfb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044196 mRNA Translation: AAC14401.1
BC012965 mRNA Translation: AAH12965.1
CCDSiCCDS19447.1
RefSeqiNP_061354.1, NM_018866.2
UniGeneiMm.10116

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IZBNMR-A22-109[»]
5L7MNMR-A22-109[»]
ProteinModelPortaliO55038
SMRiO55038
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-57395N
IntActiO55038, 4 interactors
MINTiO55038
STRINGi10090.ENSMUSP00000023840

PTM databases

iPTMnetiO55038
PhosphoSitePlusiO55038

Proteomic databases

PaxDbiO55038
PRIDEiO55038

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078
GeneIDi55985
KEGGimmu:55985
UCSCiuc008yfb.1 mouse

Organism-specific databases

CTDi10563
MGIiMGI:1888499 Cxcl13

Phylogenomic databases

eggNOGiENOG410JEN1 Eukaryota
ENOG4111E5H LUCA
GeneTreeiENSGT00530000064292
HOGENOMiHOG000220915
HOVERGENiHBG098474
InParanoidiO55038
KOiK10032
OMAiGCPNTEI
OrthoDBiEOG091G0XS0
PhylomeDBiO55038
TreeFamiTF335204

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:O55038
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023078 Expressed in 153 organ(s), highest expression level in spleen
CleanExiMM_CXCL13
ExpressionAtlasiO55038 baseline and differential
GenevisibleiO55038 MM

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXL13_MOUSE
AccessioniPrimary (citable) accession number: O55038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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