Cxcl13

Functionⁱ

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

GO - Molecular functionⁱ

CCR10 chemokine receptor binding Source: BHF-UCL
chemokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15972452
CXCR3 chemokine receptor binding Source: BHF-UCL
CXCR5 chemokine receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 9463416
fibroblast growth factor binding Source: BHF-UCL
heparin binding Source: BHF-UCL
protein heterodimerization activity Source: BHF-UCL
receptor ligand activity Source: BHF-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of GTPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15972452
antimicrobial humoral immune response mediated by antimicrobial peptide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
B cell chemotaxis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15972452
B cell chemotaxis across high endothelial venule
Source: BHF-UCL
Inferred from direct assayⁱ
- 15972452
cell-cell signaling Source: BHF-UCL
cell surface receptor signaling pathway Source: MGI
cellular response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to bacterium Source: BHF-UCL
endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
leukocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lymph node development
Source: BHF-UCL
Inferred from direct assayⁱ
- 19783990
lymphocyte chemotaxis across high endothelial venule
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15972452
negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: MGI
neutrophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell-cell adhesion mediated by integrin
Source: BHF-UCL
Inferred from direct assayⁱ
- 15972452
positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
positive regulation of integrin activation
Source: BHF-UCL
Inferred from direct assayⁱ
- 15972452
positive regulation of T cell chemotaxis Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis, Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C motif chemokine 13 Alternative name(s): B lymphocyte chemoattractant CXC chemokine BLC Small-inducible cytokine B13
Gene namesⁱ	Name:Cxcl13 Synonyms:Blc, Scyb13
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1888499 Cxcl13

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000005114	22 – 109	C-X-C motif chemokine 13Add BLAST		88

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	32 ↔ 59	By similarity
Disulfide bondⁱ	34 ↔ 75	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	O55038
PRIDEⁱ	O55038

PTM databases

iPTMnetⁱ	O55038
PhosphoSitePlusⁱ	O55038

Expressionⁱ

Tissue specificityⁱ

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Gene expression databases

Bgeeⁱ	ENSMUSG00000023078 Expressed in 153 organ(s), highest expression level in spleen
CleanExⁱ	MM_CXCL13
ExpressionAtlasⁱ	O55038 baseline and differential
Genevisibleⁱ	O55038 MM

Interactionⁱ

GO - Molecular functionⁱ

CCR10 chemokine receptor binding Source: BHF-UCL
chemokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15972452
CXCR3 chemokine receptor binding Source: BHF-UCL
CXCR5 chemokine receptor binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 9463416
fibroblast growth factor binding Source: BHF-UCL
protein heterodimerization activity Source: BHF-UCL
receptor ligand activity Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-57395N
IntActⁱ	O55038, 4 interactors
Molecular INTeraction database More...MINTⁱ	O55038
STRINGⁱ	10090.ENSMUSP00000023840

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 25	Combined sources	4
Turnⁱ	44 – 46	Combined sources	3
Beta strandⁱ	47 – 53	Combined sources	7
Beta strandⁱ	57 – 61	Combined sources	5
Beta strandⁱ	63 – 68	Combined sources	6
Beta strandⁱ	73 – 76	Combined sources	4
Helixⁱ	81 – 89	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	O55038
SMRⁱ	O55038
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410JEN1 Eukaryota ENOG4111E5H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064292
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG098474
InParanoidⁱ	O55038
KEGG Orthology (KO) More...KOⁱ	K10032
OMAⁱ	GCPNTEI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XS0
PhylomeDBⁱ	O55038
TreeFamⁱ	TF335204

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O55038-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI 
        60         70         80         90        100
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ 

APVSKRRAA

Length:109

Mass (Da):11,927

Last modified:June 1, 1998 - v1

Checksum:ⁱF5F8AF4411C56BD3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044196 mRNA Translation: AAC14401.1 BC012965 mRNA Translation: AAH12965.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19447.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061354.1, NM_018866.2
UniGeneⁱ	Mm.10116

Genome annotation databases

Ensemblⁱ	ENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078
GeneIDⁱ	55985
KEGGⁱ	mmu:55985
UCSC genome browser More...UCSCⁱ	uc008yfb.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O55038	C-X-C motif chemokine		MOUSE		109	UniRef100_O55038
C-X-C motif chemokine		MOUSE		86
UPI000B4966E2		MOUSE		88

Protein	Similar proteins		Species	Score	Length	Source
O55038	C-X-C motif chemokine		MOUSE		109	UniRef90_O55038
UPI000A3131E3		MUSPA		109
UPI000A31782E		MUSCR		109
C-X-C motif chemokine		MOUSE		86
UPI000B4966E2		MOUSE		88
+2

Protein	Similar proteins		Species	Score	Length	Source
O55038	C-X-C motif chemokine		MOUSE		109	UniRef50_O55038
C-X-C motif chemokine		NEOSC		110
c-X-C motif chemokine 13		LEPWE		110
C-X-C motif chemokine 13		ODORO		110
C-X-C motif chemokine		MUSPF		109
+38

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044196 mRNA Translation: AAC14401.1 BC012965 mRNA Translation: AAH12965.1
CCDSⁱ	CCDS19447.1
RefSeqⁱ	NP_061354.1, NM_018866.2
UniGeneⁱ	Mm.10116

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5IZB	NMR	-	A	22-109	[»]
	5L7M	NMR	-	A	22-109	[»]
ProteinModelPortalⁱ	O55038
SMRⁱ	O55038
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-57395N
IntActⁱ	O55038, 4 interactors
MINTⁱ	O55038
STRINGⁱ	10090.ENSMUSP00000023840

PTM databases

iPTMnetⁱ	O55038
PhosphoSitePlusⁱ	O55038

Proteomic databases

PaxDbⁱ	O55038
PRIDEⁱ	O55038

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078
GeneIDⁱ	55985
KEGGⁱ	mmu:55985
UCSCⁱ	uc008yfb.1 mouse

Organism-specific databases

CTDⁱ	10563
MGIⁱ	MGI:1888499 Cxcl13

Phylogenomic databases

eggNOGⁱ	ENOG410JEN1 Eukaryota ENOG4111E5H LUCA
GeneTreeⁱ	ENSGT00530000064292
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG098474
InParanoidⁱ	O55038
KOⁱ	K10032
OMAⁱ	GCPNTEI
OrthoDBⁱ	EOG091G0XS0
PhylomeDBⁱ	O55038
TreeFamⁱ	TF335204

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O55038
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000023078 Expressed in 153 organ(s), highest expression level in spleen
CleanExⁱ	MM_CXCL13
ExpressionAtlasⁱ	O55038 baseline and differential
Genevisibleⁱ	O55038 MM

Family and domain databases

CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXL13_MOUSE
Accessionⁱ	O55038Primary (citable) accession number: O55038
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	June 1, 1998
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O55038 (CXL13_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

C-X-C motif chemokine 13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ