C-X-C motif chemokine 13

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CCR10 chemokine receptor binding Source: BHF-UCL
• chemokine activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• CXCR3 chemokine receptor binding Source: BHF-UCL
• CXCR5 chemokine receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
    Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
    J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
• CXCR chemokine receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• fibroblast growth factor binding Source: BHF-UCL
• heparin binding Source: BHF-UCL
• receptor ligand activity Source: BHF-UCL

GO - Biological processⁱ

• activation of GTPase activity Source: BHF-UCLInferred from direct assayⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
• B cell chemotaxis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• B cell chemotaxis across high endothelial venule Source: BHF-UCLInferred from direct assayⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: BHF-UCL
• cell surface receptor signaling pathway Source: MGI
• cellular response to lipopolysaccharide Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• defense response to bacterium Source: BHF-UCL
• endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• killing of cells of other organism Source: MGI
• lymph node development Source: BHF-UCLInferred from direct assayⁱ
  • "Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation."
    van de Pavert S.A., Olivier B.J., Goverse G., Vondenhoff M.F., Greuter M., Beke P., Kusser K., Hopken U.E., Lipp M., Niederreither K., Blomhoff R., Sitnik K., Agace W.W., Randall T.D., de Jonge W.J., Mebius R.E.
    Nat Immunol 10:1193-1199(2009) [PubMed] [Europe PMC] [Abstract]
• lymphocyte chemotaxis across high endothelial venule Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: MGI
• neutrophil chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCLInferred from direct assayⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
• positive regulation of integrin activation Source: BHF-UCLInferred from direct assayⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell chemotaxis Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• CCR10 chemokine receptor binding Source: BHF-UCL
• chemokine activity Source: BHF-UCLInferred from direct assayⁱ
  • "CXCL13 is an arrest chemokine for B cells in high endothelial venules."
    Kanemitsu N., Ebisuno Y., Tanaka T., Otani K., Hayasaka H., Kaisho T., Akira S., Katagiri K., Kinashi T., Fujita N., Tsuruo T., Miyasaka M.
    Blood 106:2613-2618(2005) [PubMed] [Europe PMC] [Abstract]
• CXCR3 chemokine receptor binding Source: BHF-UCL
• CXCR5 chemokine receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5."
    Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B.
    J. Exp. Med. 187:655-660(1998) [PubMed] [Europe PMC] [Abstract]
• CXCR chemokine receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• fibroblast growth factor binding Source: BHF-UCL
• receptor ligand activity Source: BHF-UCL

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI 
        60         70         80         90        100
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ 

APVSKRRAA                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families