UniProtKB - O55038 (CXL13_MOUSE)
Protein
C-X-C motif chemokine 13
Gene
Cxcl13
Organism
Mus musculus (Mouse)
Status
Functioni
Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.
GO - Molecular functioni
- CCR10 chemokine receptor binding Source: BHF-UCL
- chemokine activity Source: BHF-UCL
- CXCR3 chemokine receptor binding Source: BHF-UCL
- CXCR5 chemokine receptor binding Source: BHF-UCL
- CXCR chemokine receptor binding Source: GO_Central
- fibroblast growth factor binding Source: BHF-UCL
- heparin binding Source: BHF-UCL
- receptor ligand activity Source: BHF-UCL
GO - Biological processi
- activation of GTPase activity Source: BHF-UCL
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- B cell chemotaxis Source: BHF-UCL
- B cell chemotaxis across high endothelial venule Source: BHF-UCL
- cell-cell signaling Source: BHF-UCL
- cell surface receptor signaling pathway Source: MGI
- cellular response to lipopolysaccharide Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- defense response to bacterium Source: BHF-UCL
- endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
- immune response Source: GO_Central
- inflammatory response Source: GO_Central
- killing of cells of other organism Source: MGI
- leukocyte chemotaxis Source: GO_Central
- lymph node development Source: BHF-UCL
- lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
- negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: MGI
- neutrophil chemotaxis Source: GO_Central
- positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
- positive regulation of integrin activation Source: BHF-UCL
- positive regulation of T cell chemotaxis Source: BHF-UCL
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 13Alternative name(s): B lymphocyte chemoattractant CXC chemokine BLC Small-inducible cytokine B13 |
Gene namesi | Name:Cxcl13 Synonyms:Blc, Scyb13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888499, Cxcl13 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: BHF-UCL
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000005114 | 22 – 109 | C-X-C motif chemokine 13Add BLAST | 88 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 59 | By similarity | ||
Disulfide bondi | 34 ↔ 75 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | O55038 |
PRIDEi | O55038 |
PTM databases
iPTMneti | O55038 |
PhosphoSitePlusi | O55038 |
Expressioni
Tissue specificityi
Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).
Gene expression databases
Bgeei | ENSMUSG00000023078, Expressed in spleen and 167 other tissues |
Genevisiblei | O55038, MM |
Interactioni
GO - Molecular functioni
- CCR10 chemokine receptor binding Source: BHF-UCL
- chemokine activity Source: BHF-UCL
- CXCR3 chemokine receptor binding Source: BHF-UCL
- CXCR5 chemokine receptor binding Source: BHF-UCL
- CXCR chemokine receptor binding Source: GO_Central
- fibroblast growth factor binding Source: BHF-UCL
- receptor ligand activity Source: BHF-UCL
Protein-protein interaction databases
DIPi | DIP-57395N |
IntActi | O55038, 4 interactors |
MINTi | O55038 |
STRINGi | 10090.ENSMUSP00000023840 |
Miscellaneous databases
RNActi | O55038, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | O55038 |
SMRi | O55038 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SEXJ, Eukaryota |
GeneTreei | ENSGT00530000064292 |
HOGENOMi | CLU_143902_2_0_1 |
InParanoidi | O55038 |
OMAi | PGNGCPN |
OrthoDBi | 1510748at2759 |
PhylomeDBi | O55038 |
TreeFami | TF335204 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O55038-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI
60 70 80 90 100
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ
APVSKRRAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF044196 mRNA Translation: AAC14401.1 BC012965 mRNA Translation: AAH12965.1 |
CCDSi | CCDS19447.1 |
RefSeqi | NP_061354.1, NM_018866.2 |
Genome annotation databases
Ensembli | ENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078 |
GeneIDi | 55985 |
KEGGi | mmu:55985 |
UCSCi | uc008yfb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF044196 mRNA Translation: AAC14401.1 BC012965 mRNA Translation: AAH12965.1 |
CCDSi | CCDS19447.1 |
RefSeqi | NP_061354.1, NM_018866.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5IZB | NMR | - | A | 22-109 | [»] | |
5L7M | NMR | - | A | 22-109 | [»] | |
BMRBi | O55038 | |||||
SMRi | O55038 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-57395N |
IntActi | O55038, 4 interactors |
MINTi | O55038 |
STRINGi | 10090.ENSMUSP00000023840 |
PTM databases
iPTMneti | O55038 |
PhosphoSitePlusi | O55038 |
Proteomic databases
PaxDbi | O55038 |
PRIDEi | O55038 |
Protocols and materials databases
Antibodypediai | 13544, 590 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078 |
GeneIDi | 55985 |
KEGGi | mmu:55985 |
UCSCi | uc008yfb.1, mouse |
Organism-specific databases
CTDi | 10563 |
MGIi | MGI:1888499, Cxcl13 |
Phylogenomic databases
eggNOGi | ENOG502SEXJ, Eukaryota |
GeneTreei | ENSGT00530000064292 |
HOGENOMi | CLU_143902_2_0_1 |
InParanoidi | O55038 |
OMAi | PGNGCPN |
OrthoDBi | 1510748at2759 |
PhylomeDBi | O55038 |
TreeFami | TF335204 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 55985, 1 hit in 17 CRISPR screens |
PROi | PR:O55038 |
RNActi | O55038, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023078, Expressed in spleen and 167 other tissues |
Genevisiblei | O55038, MM |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXL13_MOUSE | |
Accessioni | O55038Primary (citable) accession number: O55038 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families