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Protein

Ectonucleoside triphosphate diphosphohydrolase 2

Gene

Entpd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity).By similarity

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 208ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8850843 Phosphate bond hydrolysis by NTPDase proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 2 (EC:3.6.1.-)
Short name:
NTPDase 2
Alternative name(s):
CD39 antigen-like 1
Ecto-ATP diphosphohydrolase 2
Short name:
Ecto-ATPDase 2
Short name:
Ecto-ATPase 2
Gene namesi
Name:Entpd2
Synonyms:Cd39l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1096863 Entpd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 462ExtracellularSequence analysisAdd BLAST437
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 495CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099071 – 495Ectonucleoside triphosphate diphosphohydrolase 2Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 99By similarity
Glycosylationi129N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi242 ↔ 284By similarity
Disulfide bondi265 ↔ 310By similarity
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi323 ↔ 328By similarity
Disulfide bondi377 ↔ 399By similarity
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55026
PeptideAtlasiO55026
PRIDEiO55026

PTM databases

iPTMnetiO55026
PhosphoSitePlusiO55026

Expressioni

Inductioni

By dioxin.

Gene expression databases

BgeeiENSMUSG00000015085 Expressed in 227 organ(s), highest expression level in seminal vesicle
ExpressionAtlasiO55026 baseline and differential
GenevisibleiO55026 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198592, 1 interactor
IntActiO55026, 1 interactor
MINTiO55026
STRINGi10090.ENSMUSP00000028328

Structurei

3D structure databases

ProteinModelPortaliO55026
SMRiO55026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1386 Eukaryota
COG5371 LUCA
GeneTreeiENSGT00550000074435
HOGENOMiHOG000059572
HOVERGENiHBG018982
InParanoidiO55026
KOiK01509
OMAiSHTSMFV
OrthoDBiEOG091G05FZ
PhylomeDBiO55026
TreeFamiTF332859

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: O55026-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGKLVSLVP PLLLAAVGLA GLLLLCVPTQ DVREPPALKY GIVLDAGSSH
60 70 80 90 100
TSMFVYKWPA DKENDTGIVG QHSSCDVRGG GISSYANDPS RAGQSLVECL
110 120 130 140 150
EQALRDVPKD RYASTPLYLG ATAGMRLLNL TSPEATAKVL EAVTQTLTRY
160 170 180 190 200
PFDFRGARIL SGQDEGVFGW VTANYLLENF IKYGWVGRWI RPRKGTLGAM
210 220 230 240 250
DLGGASTQIT FETTSPSEDP DNEVHLRLYG QHYRVYTHSF LCYGRDQVLQ
260 270 280 290 300
RLLASALQIH RFHPCWPKGY STQVLLREVY QSPCTMGQRP QTFNSSATVS
310 320 330 340 350
LSGTSNAALC RDLVSGLFNI SSCPFSQCSF NGVFQPPVAG NFIAFSAFYY
360 370 380 390 400
TVDFLKTVMG LPVGTLKQLE DATETTCNQT WAELQARVPG QQTRLPDYCA
410 420 430 440 450
VAMFIHQLLS RGYRFDERSF RGVVFEKKAA DTAVGWALGY MLNLTNLIPA
460 470 480 490
DLPGLRKGTH FSSWVALLLL FTVLILAALV LLLRQVRSAK SPGAL
Length:495
Mass (Da):54,319
Last modified:March 15, 2004 - v2
Checksum:iA76468A0CBF86AAC
GO
Isoform Short (identifier: O55026-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-132: LTS → MAG
     133-495: Missing.

Show »
Length:132
Mass (Da):13,857
Checksum:i12D83F5F057F6A7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti400A → T in AAC24347 (PubMed:9624117).Curated1
Sequence conflicti414R → S in AAC24347 (PubMed:9624117).Curated1
Sequence conflicti437A → T in AAC24347 (PubMed:9624117).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003611130 – 132LTS → MAG in isoform Short. 1 Publication3
Alternative sequenceiVSP_003612133 – 495Missing in isoform Short. 1 PublicationAdd BLAST363

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91511 mRNA Translation: AAB81014.1
AF042811 mRNA Translation: AAC24347.1
AY376711 mRNA Translation: AAQ86586.1
AK002553 mRNA Translation: BAB22182.1
CCDSiCCDS15770.1 [O55026-1]
RefSeqiNP_033979.2, NM_009849.2 [O55026-1]
UniGeneiMm.482100

Genome annotation databases

EnsembliENSMUST00000028328; ENSMUSP00000028328; ENSMUSG00000015085 [O55026-1]
GeneIDi12496
KEGGimmu:12496
UCSCiuc008irw.2 mouse [O55026-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91511 mRNA Translation: AAB81014.1
AF042811 mRNA Translation: AAC24347.1
AY376711 mRNA Translation: AAQ86586.1
AK002553 mRNA Translation: BAB22182.1
CCDSiCCDS15770.1 [O55026-1]
RefSeqiNP_033979.2, NM_009849.2 [O55026-1]
UniGeneiMm.482100

3D structure databases

ProteinModelPortaliO55026
SMRiO55026
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198592, 1 interactor
IntActiO55026, 1 interactor
MINTiO55026
STRINGi10090.ENSMUSP00000028328

PTM databases

iPTMnetiO55026
PhosphoSitePlusiO55026

Proteomic databases

PaxDbiO55026
PeptideAtlasiO55026
PRIDEiO55026

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028328; ENSMUSP00000028328; ENSMUSG00000015085 [O55026-1]
GeneIDi12496
KEGGimmu:12496
UCSCiuc008irw.2 mouse [O55026-1]

Organism-specific databases

CTDi954
MGIiMGI:1096863 Entpd2

Phylogenomic databases

eggNOGiKOG1386 Eukaryota
COG5371 LUCA
GeneTreeiENSGT00550000074435
HOGENOMiHOG000059572
HOVERGENiHBG018982
InParanoidiO55026
KOiK01509
OMAiSHTSMFV
OrthoDBiEOG091G05FZ
PhylomeDBiO55026
TreeFamiTF332859

Enzyme and pathway databases

ReactomeiR-MMU-8850843 Phosphate bond hydrolysis by NTPDase proteins

Miscellaneous databases

PROiPR:O55026
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015085 Expressed in 227 organ(s), highest expression level in seminal vesicle
ExpressionAtlasiO55026 baseline and differential
GenevisibleiO55026 MM

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENTP2_MOUSE
AccessioniPrimary (citable) accession number: O55026
Secondary accession number(s): O35928, Q9DCR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 15, 2004
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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