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Protein

Inositol monophosphatase 1

Gene

Impa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.By similarity

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.By similarity
Alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate.By similarity

Cofactori

Mg2+1 Publication

Activity regulationi

Inhibited by Li+, Ca2+ and Mn2+, but also by Mg2+ at concentrations above 3 mM.By similarity

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol monophosphatase 1 (Impa1), Inositol monophosphatase 3 (Impad1), Inositol monophosphatase 2 (Impa2), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa1), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa2), Inositol-1-monophosphatase (Impa1)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Magnesium 1; catalytic1 Publication1
Binding sitei70SubstrateCurated1
Metal bindingi90Magnesium 1; catalytic1 Publication1
Metal bindingi90Magnesium 21 Publication1
Metal bindingi92Magnesium 1; via carbonyl oxygen; catalytic1 Publication1
Metal bindingi93Magnesium 21 Publication1
Binding sitei213SubstrateBy similarity1
Metal bindingi220Magnesium 21 Publication1
Binding sitei220SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandLithium, Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00823;UER00788

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol monophosphatase 1 (EC:3.1.3.25By similarity)
Short name:
IMP 1
Short name:
IMPase 1
Alternative name(s):
D-galactose 1-phosphate phosphataseBy similarity (EC:3.1.3.94By similarity)
Inositol-1(or 4)-monophosphatase 1
Lithium-sensitive myo-inositol monophosphatase A1
Gene namesi
Name:Impa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1933158 Impa1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425141 – 277Inositol monophosphatase 1Add BLAST277

Proteomic databases

EPDiO55023
MaxQBiO55023
PaxDbiO55023
PeptideAtlasiO55023
PRIDEiO55023

PTM databases

iPTMnetiO55023
PhosphoSitePlusiO55023
SwissPalmiO55023

Expressioni

Tissue specificityi

Mostly expressed in brain, small intestine, testis, kidney, and spleen (at protein level).1 Publication

Inductioni

By lithium Li+ in hippocamp.1 Publication

Gene expression databases

CleanExiMM_IMPA1

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO55023, 2 interactors
STRINGi10090.ENSMUSP00000068174

Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO55023
SMRiO55023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 95Substrate bindingCurated6
Regioni194 – 196Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2951 Eukaryota
COG0483 LUCA
HOGENOMiHOG000282238
HOVERGENiHBG052123
InParanoidiO55023
PhylomeDBiO55023

Family and domain databases

CDDicd01639 IMPase, 1 hit
InterProiView protein in InterPro
IPR033942 IMPase
IPR020583 Inositol_monoP_metal-BS
IPR020552 Inositol_monoPase_Li-sen
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PRINTSiPR00377 IMPHPHTASES
PR00378 LIIMPHPHTASE
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O55023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPWQECMD YAVILARQAG EMIREALKNE MDVMIKSSPA DLVTVTDQKV
60 70 80 90 100
EKMLMSSIKE KYPCHSFIGE ESVAAGEKTV FTESPTWFID PIDGTTNFVH
110 120 130 140 150
RFPFVAVSIG FLVNKEMEFG IVYSCVEDKM YTGRKGKGAF CNGQKLQVSQ
160 170 180 190 200
QEDITKSLLV TELGSSRKPE TLRIVLSNME KLCSIPIHGI RSVGTAAVNM
210 220 230 240 250
CLVATGGADA YYEMGIHCWD MAGAGIIVTE AGGVLMDVTG GPFDLMSRRI
260 270
IAANSITLAK RIAKEIEIIP LQRDDES
Length:277
Mass (Da):30,436
Last modified:June 1, 1998 - v1
Checksum:iEDBDB7BD24748E9D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q924B0Q924B0_MOUSE
Inositol-1-monophosphatase
Impa1 mCG_1639
277Annotation score:
A0A0A6YW07A0A0A6YW07_MOUSE
Inositol-1-monophosphatase
Impa1
208Annotation score:
Q80ZJ2Q80ZJ2_MOUSE
Inositol-1-monophosphatase
Impa1
276Annotation score:
D3Z703D3Z703_MOUSE
Inositol monophosphatase 1
Impa1
89Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042730 mRNA Translation: AAB97469.1
CCDSiCCDS17240.1
UniGeneiMm.183042

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042730 mRNA Translation: AAB97469.1
CCDSiCCDS17240.1
UniGeneiMm.183042

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AS5X-ray2.43A/B/C/D1-277[»]
ProteinModelPortaliO55023
SMRiO55023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO55023, 2 interactors
STRINGi10090.ENSMUSP00000068174

PTM databases

iPTMnetiO55023
PhosphoSitePlusiO55023
SwissPalmiO55023

Proteomic databases

EPDiO55023
MaxQBiO55023
PaxDbiO55023
PeptideAtlasiO55023
PRIDEiO55023

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1933158 Impa1

Phylogenomic databases

eggNOGiKOG2951 Eukaryota
COG0483 LUCA
HOGENOMiHOG000282238
HOVERGENiHBG052123
InParanoidiO55023
PhylomeDBiO55023

Enzyme and pathway databases

UniPathwayi
UPA00823;UER00788

Miscellaneous databases

ChiTaRSiImpa1 mouse
PROiPR:O55023
SOURCEiSearch...

Gene expression databases

CleanExiMM_IMPA1

Family and domain databases

CDDicd01639 IMPase, 1 hit
InterProiView protein in InterPro
IPR033942 IMPase
IPR020583 Inositol_monoP_metal-BS
IPR020552 Inositol_monoPase_Li-sen
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PRINTSiPR00377 IMPHPHTASES
PR00378 LIIMPHPHTASE
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIMPA1_MOUSE
AccessioniPrimary (citable) accession number: O55023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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