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Protein

Trafficking protein particle complex subunit 3

Gene

Trappc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: MGI
  • intra-Golgi vesicle-mediated transport Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3
Alternative name(s):
BET3 homolog
Gene namesi
Name:Trappc3Imported
Synonyms:Bet3By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1351486 Trappc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115731 – 180Trafficking protein particle complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi68S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiO55013
PaxDbiO55013
PeptideAtlasiO55013
PRIDEiO55013
TopDownProteomicsiO55013

2D gel databases

REPRODUCTION-2DPAGEiO55013
UCD-2DPAGEiO55013

PTM databases

iPTMnetiO55013
PhosphoSitePlusiO55013
SwissPalmiO55013

Expressioni

Tissue specificityi

Widely expressed. Expressed in lung, heart, liver, spleen, brain and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000028847 Expressed in 293 organ(s), highest expression level in brain
CleanExiMM_TRAPPC3
ExpressionAtlasiO55013 baseline and differential
GenevisibleiO55013 MM

Interactioni

Subunit structurei

Homodimer. Component of the multisubunit transport protein particle (TRAPP) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Heterodimer with TRAPPC6b. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation.By similarity

Protein-protein interaction databases

BioGridi205122, 4 interactors
IntActiO55013, 5 interactors
STRINGi10090.ENSMUSP00000030660

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO55013
SMRiO55013
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO55013

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3330 Eukaryota
ENOG410Z1VV LUCA
GeneTreeiENSGT00390000003880
HOGENOMiHOG000186184
HOVERGENiHBG055045
InParanoidiO55013
KOiK20302
OMAiSVTNWSP
OrthoDBiEOG091G0N4X
PhylomeDBiO55013
TreeFamiTF300091

Family and domain databases

CDDicd14942 TRAPPC3_bet3, 1 hit
InterProiView protein in InterPro
IPR016721 Bet3
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
PANTHERiPTHR13048 PTHR13048, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequencei

Sequence statusi: Complete.

O55013-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDRMGYN
60 70 80 90 100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG
110 120 130 140 150
DEFSLILENN PLVDFVELPD NHSALIYSNL LCGVLRGALE MVQMAVEAKF
160 170 180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Length:180
Mass (Da):20,302
Last modified:June 1, 1998 - v1
Checksum:iB8D57A33D68C0D94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041433 mRNA Translation: AAB96937.1
BC003736 mRNA Translation: AAH03736.1
CCDSiCCDS18647.1
RefSeqiNP_038746.1, NM_013718.2
UniGeneiMm.8392

Genome annotation databases

EnsembliENSMUST00000030660; ENSMUSP00000030660; ENSMUSG00000028847
GeneIDi27096
KEGGimmu:27096
UCSCiuc008utc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041433 mRNA Translation: AAB96937.1
BC003736 mRNA Translation: AAH03736.1
CCDSiCCDS18647.1
RefSeqiNP_038746.1, NM_013718.2
UniGeneiMm.8392

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WC8X-ray1.90A1-180[»]
1WC9X-ray1.60A8-172[»]
2J3RX-ray2.60A1-180[»]
2J3TX-ray2.40A1-180[»]
2J3WX-ray2.10D/E1-180[»]
2PWNX-ray2.04A1-180[»]
ProteinModelPortaliO55013
SMRiO55013
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205122, 4 interactors
IntActiO55013, 5 interactors
STRINGi10090.ENSMUSP00000030660

PTM databases

iPTMnetiO55013
PhosphoSitePlusiO55013
SwissPalmiO55013

2D gel databases

REPRODUCTION-2DPAGEiO55013
UCD-2DPAGEiO55013

Proteomic databases

EPDiO55013
PaxDbiO55013
PeptideAtlasiO55013
PRIDEiO55013
TopDownProteomicsiO55013

Protocols and materials databases

DNASUi27096
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030660; ENSMUSP00000030660; ENSMUSG00000028847
GeneIDi27096
KEGGimmu:27096
UCSCiuc008utc.1 mouse

Organism-specific databases

CTDi27095
MGIiMGI:1351486 Trappc3

Phylogenomic databases

eggNOGiKOG3330 Eukaryota
ENOG410Z1VV LUCA
GeneTreeiENSGT00390000003880
HOGENOMiHOG000186184
HOVERGENiHBG055045
InParanoidiO55013
KOiK20302
OMAiSVTNWSP
OrthoDBiEOG091G0N4X
PhylomeDBiO55013
TreeFamiTF300091

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTrappc3 mouse
EvolutionaryTraceiO55013
PROiPR:O55013
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028847 Expressed in 293 organ(s), highest expression level in brain
CleanExiMM_TRAPPC3
ExpressionAtlasiO55013 baseline and differential
GenevisibleiO55013 MM

Family and domain databases

CDDicd14942 TRAPPC3_bet3, 1 hit
InterProiView protein in InterPro
IPR016721 Bet3
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
PANTHERiPTHR13048 PTHR13048, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC3_MOUSE
AccessioniPrimary (citable) accession number: O55013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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