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UniProtKB - O55007 (RGPA1_RAT)

Entry version 124 (02 Dec 2020)
Sequence version 2 (29 Oct 2014)
Previous versions | rss
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Protein

Ral GTPase-activating protein subunit alpha-1

Gene

Ralgapa1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ral GTPase-activating protein subunit alpha-1
Alternative name(s):
GAP-related-interacting partner to E12
Short name:
GRIPE
GTPase-activating RapGAP domain-like 1
Tuberin-like protein 1
p240
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ralgapa1
Synonyms:Garnl1, Tulip1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Rat genome database

More...RGDi		620642, Ralgapa1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567551 – 2035Ral GTPase-activating protein subunit alpha-1Add BLAST2035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei710PhosphoserineBy similarity1
Modified residuei720PhosphoserineBy similarity1
Modified residuei753PhosphothreonineBy similarity1
Modified residuei772PhosphoserineBy similarity1
Modified residuei777PhosphothreonineBy similarity1
Modified residuei796PhosphoserineCombined sources1
Modified residuei859PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei863PhosphoserineCombined sources1
Modified residuei985PhosphoserineBy similarity1
Modified residuei989PhosphoserineBy similarity1
Modified residuei993PhosphoserineBy similarity1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1001PhosphothreonineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1477PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O55007

PRoteomics IDEntifications database

More...PRIDEi		O55007

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O55007

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O55007

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, thymus and testis with lower levels in lung and spleen and barely detectable in heart or liver (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000046256, Expressed in female gonad and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O55007, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O55007, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity.

Interacts with the HLH region of TCF3/isoform E12 (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O55007, 2 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000059440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O55007

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1795 – 2003Rap-GAPPROSITE-ProRule annotationAdd BLAST209

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1326 – 2034Minimal domain that binds to TCF3/E12By similarityAdd BLAST709

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1713 – 1746Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3686, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183139

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001676_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O55007

Database of Orthologous Groups

More...OrthoDBi		157372at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR027107, Tuberin/Ral-act_asu

The PANTHER Classification System

More...PANTHERi		PTHR10063, PTHR10063, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02145, Rap_GAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: O55007-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENADS IDLKQFFDQH 
        60         70         80         90        100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH 
       110        120        130        140        150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM 
       160        170        180        190        200
FSCLIPGFSA PQSEYGPRTL DNLINPPLNL QETQVTIEEV TPLVPPQSGD 
       210        220        230        240        250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP 
       260        270        280        290        300
YIFPNLCKEN SLYHPVLDIP QVRPKPHYVM VKKDAETNET IYCTKEPFIQ 
       310        320        330        340        350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK 
       360        370        380        390        400
NDTVDKADKT AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV 
       410        420        430        440        450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEGKPLFMQ 
       460        470        480        490        500
EPEETVITSS DIPCSENVTD HDISIEDGEK REEENGTNIS EHVRNSTWTK 
       510        520        530        540        550
NGSYQEAFHV SEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL 
       560        570        580        590        600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 
       610        620        630        640        650
LQFQGKKNMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS 
       660        670        680        690        700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK 
       710        720        730        740        750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR 
       760        770        780        790        800
QKTVDIDDSQ ILPRSTRVRH FSQSEDTGNE VFGALHEEQP LPRSSSTSDI 
       810        820        830        840        850
LEPFTVERAK VNKEDTSPKL PPLNSETGGS SANVPDLMDE FIAERLRSGN 
       860        870        880        890        900
ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 
       910        920        930        940        950
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DSGSGHHQST 
       960        970        980        990       1000
EEQEVASLTT LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ 
      1010       1020       1030       1040       1050
TPSPSTLNID HMEQKDLQLD EKLHHSVLQT PDDLEISEFP SECCSVMAGG 
      1060       1070       1080       1090       1100
TLTGWHADVA TVMWRRMLGI LGDVNAIMDP EIHAQVFDYL CELWQNLAKI 
      1110       1120       1130       1140       1150
RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY KQGKLHAYKL 
      1160       1170       1180       1190       1200
ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS 
      1210       1220       1230       1240       1250
LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL 
      1260       1270       1280       1290       1300
PALHPSTPDI AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI 
      1310       1320       1330       1340       1350
CEELVHESHH PQIKEALNVI CVSLKFTNKT VAHVACNMLH MLVHYAPRLQ 
      1360       1370       1380       1390       1400
TYQPDSPLKI IQILIATITH LLPSTEASSY EMDKRLVVSL LLCLLDWIMA 
      1410       1420       1430       1440       1450
LPLKTLLQSV HSTGAENEKT EKSVLNCIYK VLHGCVYGAQ SFSHPKYFPI 
      1460       1470       1480       1490       1500
SLSDLASVDY DPFMHLESLR EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL 
      1510       1520       1530       1540       1550
ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL 
      1560       1570       1580       1590       1600
FDSPNIQFFV LNNTTLVSCI QIRSEESVPG GGLAAGLVSA NSNVRIIVRD 
      1610       1620       1630       1640       1650
LSGKYSWDSA ILYGPPIVSG LPEPTSFILS MSYQEKPEEP PTSNECLEDI 
      1660       1670       1680       1690       1700
TVKDGLSLQL RRFRETVPTW STIREEEDVL DELLQYLGTT SPECLQRTGI 
      1710       1720       1730       1740       1750
SLNVPAPQPV CISEKQENDV INAILKQYTE EKEFVEKHFN DLNMKASEQD 
      1760       1770       1780       1790       1800
EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS 
      1810       1820       1830       1840       1850
RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH 
      1860       1870       1880       1890       1900
CGFMGGLQKN KSTGLTTPYF ATSTVEVIFH VSTRMPSESD DSLTKKLRHL 
      1910       1920       1930       1940       1950
GNDEVHIVWS EHTRDYRRGI IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV 
      1960       1970       1980       1990       2000
PFFGPLFDGA IVNGKVLPIM VRSTAINASR ALKSLIPLYQ NLYEERARYL 
      2010       2020       2030 
QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADADH
Length:2,035
Mass (Da):229,447
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BF777C25ADDDA4E
GO
Isoform 2 (identifier: O55007-3) [UniParc]FASTAAdd to basket
Also known as: Tulip 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1134: Missing.
     2034-2035: DH → GKNKREC

Show »
Length:906
Mass (Da):101,955
Checksum:i982D359020C7232B
GO
Isoform 1 (identifier: O55007-1) [UniParc]FASTAAdd to basket
Also known as: Tulip 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1174: Missing.
     1897-1921: LRHLGNDEVHIVWSEHTRDYRRGII → INWRIALSFSIKDSVGILMGIPLTL
     1922-2035: Missing.

Show »
Length:747
Mass (Da):83,228
Checksum:i5F2F682344A36BCA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140TAA3A0A140TAA3_RAT
Ral GTPase-activating protein subun...
Ralgapa1
1,823Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MY46A0A0A0MY46_RAT
Ral GTPase-activating protein subun...
Ralgapa1
724Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB97076 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1150L → F in AAB97076 (Ref. 1) 1
Sequence conflicti1406L → I in AAB97076 (Ref. 1) 1
Sequence conflicti1688G → R in AAB97075 (Ref. 1) 1
Sequence conflicti1688G → R in AAB97076 (Ref. 1) 1
Sequence conflicti1691S → N in AAB97076 (Ref. 1) 1
Sequence conflicti1992L → F in AAB97076 (Ref. 1) 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0567791 – 1174Missing in isoform 1. 1 PublicationAdd BLAST1174
Alternative sequenceiVSP_0567801 – 1134Missing in isoform 2. CuratedAdd BLAST1134
Alternative sequenceiVSP_0567811897 – 1921LRHLG…RRGII → INWRIALSFSIKDSVGILMG IPLTL in isoform 1. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0567821922 – 2035Missing in isoform 1. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_0567832034 – 2035DH → GKNKREC in isoform 2. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF041106 mRNA Translation: AAB97075.1
AF041107 mRNA Translation: AAB97076.1 Frameshift.
AABR06044125 Genomic DNA No translation available.
AABR06044126 Genomic DNA No translation available.
AABR06044127 Genomic DNA No translation available.
AABR06044128 Genomic DNA No translation available.
AABR06044129 Genomic DNA No translation available.
AABR06044130 Genomic DNA No translation available.
AABR06044131 Genomic DNA No translation available.
AABR06044132 Genomic DNA No translation available.
AABR06044133 Genomic DNA No translation available.
AABR06044134 Genomic DNA No translation available.
AABR06044135 Genomic DNA No translation available.
AABR06044136 Genomic DNA No translation available.
AABR06044137 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_064468.3, NM_020083.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000083857; ENSRNOP00000073377; ENSRNOG00000046256 [O55007-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:56785

UCSC genome browser

More...UCSCi		RGD:620642, rat [O55007-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041106 mRNA Translation: AAB97075.1
AF041107 mRNA Translation: AAB97076.1 Frameshift.
AABR06044125 Genomic DNA No translation available.
AABR06044126 Genomic DNA No translation available.
AABR06044127 Genomic DNA No translation available.
AABR06044128 Genomic DNA No translation available.
AABR06044129 Genomic DNA No translation available.
AABR06044130 Genomic DNA No translation available.
AABR06044131 Genomic DNA No translation available.
AABR06044132 Genomic DNA No translation available.
AABR06044133 Genomic DNA No translation available.
AABR06044134 Genomic DNA No translation available.
AABR06044135 Genomic DNA No translation available.
AABR06044136 Genomic DNA No translation available.
AABR06044137 Genomic DNA No translation available.
RefSeqiNP_064468.3, NM_020083.3

3D structure databases

SMRiO55007
ModBaseiSearch...

Protein-protein interaction databases

IntActiO55007, 2 interactors
STRINGi10116.ENSRNOP00000059440

PTM databases

iPTMnetiO55007
PhosphoSitePlusiO55007

Proteomic databases

PaxDbiO55007
PRIDEiO55007

Genome annotation databases

EnsembliENSRNOT00000083857; ENSRNOP00000073377; ENSRNOG00000046256 [O55007-1]
GeneIDi56785
KEGGirno:56785
UCSCiRGD:620642, rat [O55007-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		253959
RGDi620642, Ralgapa1

Phylogenomic databases

eggNOGiKOG3686, Eukaryota
GeneTreeiENSGT00950000183139
HOGENOMiCLU_001676_0_0_1
InParanoidiO55007
OrthoDBi157372at2759

Miscellaneous databases

Protein Ontology

More...PROi		PR:O55007

Gene expression databases

BgeeiENSRNOG00000046256, Expressed in female gonad and 21 other tissues
ExpressionAtlasiO55007, baseline and differential
GenevisibleiO55007, RN

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR027107, Tuberin/Ral-act_asu
PANTHERiPTHR10063, PTHR10063, 1 hit
PfamiView protein in Pfam
PF02145, Rap_GAP, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
SSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50085, RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGPA1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O55007
Secondary accession number(s): F1LSW3, O55008
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 29, 2014
Last modified: December 2, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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