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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene

Bnip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Gene namesi
Name:Bnip3
Synonyms:Nip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109326 Bnip3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649651 – 187BCL2/adenovirus E1B 19 kDa protein-interacting protein 3Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei77PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO55003
PaxDbiO55003
PeptideAtlasiO55003
PRIDEiO55003

PTM databases

iPTMnetiO55003
PhosphoSitePlusiO55003

Expressioni

Gene expression databases

BgeeiENSMUSG00000078566 Expressed in 116 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_BNIP3
ExpressionAtlasiO55003 baseline and differential
GenevisibleiO55003 MM

Interactioni

Subunit structurei

Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198377, 3 interactors
STRINGi10090.ENSMUSP00000101718

Structurei

3D structure databases

ProteinModelPortaliO55003
SMRiO55003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi93 – 118BH3Add BLAST26

Sequence similaritiesi

Belongs to the NIP3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYW Eukaryota
ENOG4111KXP LUCA
GeneTreeiENSGT00390000013415
HOGENOMiHOG000232139
HOVERGENiHBG050707
InParanoidiO55003
KOiK15464
OMAiKDWKFKH
OrthoDBiEOG091G0REJ
PhylomeDBiO55003
TreeFamiTF315424

Family and domain databases

InterProiView protein in InterPro
IPR010548 BNIP3
PANTHERiPTHR15186 PTHR15186, 1 hit
PfamiView protein in Pfam
PF06553 BNIP3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O55003-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQSGEENLQ GSWVELHFSN GNGSSVPASV SIYNGDMEKI LLDAQHESGR
60 70 80 90 100
SSSKSSHCDS PPRSQTPQDT NRAEIDSHSF GEKNSTLSEE DYIERRREVE
110 120 130 140 150
SILKKNSDWI WDWSSRPENI PPKEFLFKHP KRTATLSMRN TSVMKKGGIF
160 170 180
SADFLKVFLP SLLLSHLLAI GLGIYIGRRL TTSTSTF
Length:187
Mass (Da):20,978
Last modified:June 1, 1998 - v1
Checksum:i901BCFACF43EE989
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GT26A0A1B0GT26_MOUSE
BCL2/adenovirus E1B 19 kDa protein-...
Bnip3
173Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041054 mRNA Translation: AAD02922.1
AK014223 mRNA Translation: BAB29214.1
AK075943 mRNA Translation: BAC36072.1
AK152610 mRNA Translation: BAE31356.1
BC046603 mRNA Translation: AAH46603.1
CCDSiCCDS40168.1
RefSeqiNP_033890.1, NM_009760.4
UniGeneiMm.378890

Genome annotation databases

EnsembliENSMUST00000106112; ENSMUSP00000101718; ENSMUSG00000078566
GeneIDi12176
KEGGimmu:12176
UCSCiuc009kfg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041054 mRNA Translation: AAD02922.1
AK014223 mRNA Translation: BAB29214.1
AK075943 mRNA Translation: BAC36072.1
AK152610 mRNA Translation: BAE31356.1
BC046603 mRNA Translation: AAH46603.1
CCDSiCCDS40168.1
RefSeqiNP_033890.1, NM_009760.4
UniGeneiMm.378890

3D structure databases

ProteinModelPortaliO55003
SMRiO55003
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198377, 3 interactors
STRINGi10090.ENSMUSP00000101718

PTM databases

iPTMnetiO55003
PhosphoSitePlusiO55003

Proteomic databases

MaxQBiO55003
PaxDbiO55003
PeptideAtlasiO55003
PRIDEiO55003

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106112; ENSMUSP00000101718; ENSMUSG00000078566
GeneIDi12176
KEGGimmu:12176
UCSCiuc009kfg.1 mouse

Organism-specific databases

CTDi664
MGIiMGI:109326 Bnip3

Phylogenomic databases

eggNOGiENOG410IHYW Eukaryota
ENOG4111KXP LUCA
GeneTreeiENSGT00390000013415
HOGENOMiHOG000232139
HOVERGENiHBG050707
InParanoidiO55003
KOiK15464
OMAiKDWKFKH
OrthoDBiEOG091G0REJ
PhylomeDBiO55003
TreeFamiTF315424

Miscellaneous databases

PROiPR:O55003
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078566 Expressed in 116 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_BNIP3
ExpressionAtlasiO55003 baseline and differential
GenevisibleiO55003 MM

Family and domain databases

InterProiView protein in InterPro
IPR010548 BNIP3
PANTHERiPTHR15186 PTHR15186, 1 hit
PfamiView protein in Pfam
PF06553 BNIP3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBNIP3_MOUSE
AccessioniPrimary (citable) accession number: O55003
Secondary accession number(s): Q544Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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