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Protein

Peptidyl-prolyl cis-trans isomerase FKBP7

Gene

Fkbp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Miscellaneous

Binds calcium.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi154 – 1651PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi198 – 2092PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • FK506 binding Source: GO_Central
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)
Short name:
PPIase FKBP7
Alternative name(s):
23 kDa FK506-binding protein
Short name:
23 kDa FKBP
Short name:
FKBP-23
FK506-binding protein 7
Short name:
FKBP-7
Rotamase
Gene namesi
Name:Fkbp7
Synonyms:Fkbp23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1336879 Fkbp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002551420 – 218Peptidyl-prolyl cis-trans isomerase FKBP7Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO54998
PeptideAtlasiO54998
PRIDEiO54998

PTM databases

PhosphoSitePlusiO54998

Expressioni

Tissue specificityi

Expressed at highest levels in heart, lung and testis. Weakly expressed in kidney and lymph node. Little or no expression detected in brain, thymus, spleen and liver.1 Publication

Developmental stagei

Expression begins at embryonic day 8.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000002732 Expressed in 275 organ(s), highest expression level in hindlimb long bone
CleanExiMM_FKBP7
ExpressionAtlasiO54998 baseline and differential
GenevisibleiO54998 MM

Interactioni

Protein-protein interaction databases

BioGridi199688, 1 interactor
STRINGi10090.ENSMUSP00000002809

Structurei

3D structure databases

ProteinModelPortaliO54998
SMRiO54998
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 141PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST93
Domaini141 – 176EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini185 – 218EF-hand 2PROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi215 – 218Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiO54998
KOiK09573
OMAiHRPENCS
OrthoDBiEOG091G02W1
PhylomeDBiO54998
TreeFamiTF105296

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00254 FKBP_C, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O54998-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLLFRLAVF LSLWCCSDAQ GQTKEESTEE VKIEVLHRPE NCSKTSRKGD
60 70 80 90 100
LLNAHYDGYL AKDGSKFYCS RTQDEGHPKW FVLGVGHVIK GLDIAMMDMC
110 120 130 140 150
PGEKRKVIIP PSFAYGKEGY AEGKIPPNAT LMFEIELYAV TKGPRSIETF
160 170 180 190 200
KQIDTDNDRQ LSKAEIELYL QKDFEKDANP RDKSYQKAVL EDIFKKNDHN
210
GDGFISPKEY NVHQHDEL
Length:218
Mass (Da):24,913
Last modified:June 1, 1998 - v1
Checksum:iDB0AE509E60EEEBA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJI5H3BJI5_MOUSE
Peptidylprolyl isomerase
Fkbp7
123Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040252 mRNA Translation: AAC79959.1
BC032961 mRNA Translation: AAH32961.1
CCDSiCCDS16161.1
RefSeqiNP_034352.1, NM_010222.2
UniGeneiMm.24720

Genome annotation databases

EnsembliENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732
GeneIDi14231
KEGGimmu:14231
UCSCiuc008kfh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040252 mRNA Translation: AAC79959.1
BC032961 mRNA Translation: AAH32961.1
CCDSiCCDS16161.1
RefSeqiNP_034352.1, NM_010222.2
UniGeneiMm.24720

3D structure databases

ProteinModelPortaliO54998
SMRiO54998
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199688, 1 interactor
STRINGi10090.ENSMUSP00000002809

PTM databases

PhosphoSitePlusiO54998

Proteomic databases

PaxDbiO54998
PeptideAtlasiO54998
PRIDEiO54998

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732
GeneIDi14231
KEGGimmu:14231
UCSCiuc008kfh.2 mouse

Organism-specific databases

CTDi51661
MGIiMGI:1336879 Fkbp7

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiO54998
KOiK09573
OMAiHRPENCS
OrthoDBiEOG091G02W1
PhylomeDBiO54998
TreeFamiTF105296

Miscellaneous databases

PROiPR:O54998
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002732 Expressed in 275 organ(s), highest expression level in hindlimb long bone
CleanExiMM_FKBP7
ExpressionAtlasiO54998 baseline and differential
GenevisibleiO54998 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00254 FKBP_C, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP7_MOUSE
AccessioniPrimary (citable) accession number: O54998
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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