Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prominin-1

Gene

Prom1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.1 Publication

Miscellaneous

Fundus images and light microscopy of retinal sections from transgenic mice expressing mutant PROM1 reveal progressive retinal abnormalities visible as subretinal deposits and photoreceptor atrophy.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actinin binding Source: MGI
  • cadherin binding Source: MGI
  • cholesterol binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prominin-1
Alternative name(s):
Antigen AC133 homolog
Prominin-like protein 1
CD_antigen: CD133
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prom1
Synonyms:Prom, Proml1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1100886 Prom1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 107ExtracellularSequence analysisAdd BLAST88
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 434ExtracellularSequence analysisAdd BLAST255
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Topological domaini456 – 487CytoplasmicSequence analysisAdd BLAST32
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 794ExtracellularSequence analysisAdd BLAST286
Transmembranei795 – 815HelicalSequence analysisAdd BLAST21
Topological domaini816 – 867CytoplasmicSequence analysisAdd BLAST52

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Progressive degeneration and functional deterioration of both cone and rod photoreceptors associated with impaired morphogenesis of the disks and OS.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002581420 – 867Prominin-1Add BLAST848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei226N6-acetyllysineBy similarity1
Modified residuei258N6-acetyllysineBy similarity1
Modified residuei265N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi273N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi291N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi732N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei865PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation at Lys-226, Lys-258 and Lys-265 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O54990

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O54990

PeptideAtlas

More...
PeptideAtlasi
O54990

PRoteomics IDEntifications database

More...
PRIDEi
O54990

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O54990

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O54990

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the submandibular gland, expressed on the apical side of epithelial cells. In the parotid gland, expressed in the intercalated ducts. In the sublingual gland, expressed in intercalated ducts. In the extraorbital lacrimal gland, expressed in the intercalated tubules and larger intralobular ducts. Expressed in the retina. Present in urine within small membrane particles (at protein level). In the embryo, expressed on the apical side of neuroepithelial cells and of other epithelia such as lung buds, gut and ureter buds. In the adult, expressed at the apical side of the kidney tubules and of the ependymal layer of the brain. Not expressed in gut, liver, lung, pituitary, adrenal, heart or spleen. Localized to the nascent disk membranes at the base of the rod outer segment in the retina (at protein level).4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At birth, is detected at the interface between the developing neuroretina and the retinal pigment epithelium (RPE) layer. In the postnatal retina (P20) detected in photoreceptors, with particular concentration in the region of plasma membrane evaginations at the basal part of the outer segment (OS). Expressed by rod and cone photoreceptor cells, most abundantly between the OS and inner segment (IS), in close proximity to the connecting cilium.1 Publication

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_PROM1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202393, 1 interactor

Protein interaction database and analysis system

More...
IntActi
O54990, 1 interactor

Molecular INTeraction database

More...
MINTi
O54990

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000073751

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O54990

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prominin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4331 Eukaryota
ENOG410XRG0 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115704

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053690

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O54990

KEGG Orthology (KO)

More...
KOi
K06532

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O54990

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008795 Prominin

The PANTHER Classification System

More...
PANTHERi
PTHR22730 PTHR22730, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05478 Prominin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O54990-1) [UniParc]FASTAAdd to basket
Also known as: S2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG
60 70 80 90 100
IVGPLYKMVH IFLSVVQPND FPLDLIKKLI QNKKFDISVD SKEPEIIVLA
110 120 130 140 150
LKIALYEIGV LICAILGLLF IILMPLVGCF FCMCRCCNKC GGEMHQRQKQ
160 170 180 190 200
NAPCRRKCLG LSLLVICLLM SLGIIYGFVA NQQTRTRIKG TQKLAKSNFR
210 220 230 240 250
DFQTLLTETP KQIDYVVEQY TNTKNKAFSD LDGIGSVLGG RIKDQLKPKV
260 270 280 290 300
TPVLEEIKAM ATAIKQTKDA LQNMSSSLKS LQDAATQLNT NLSSVRNSIE
310 320 330 340 350
NSLSSSDCTS DPASKICDSI RPSLSSLGSS LNSSQLPSVD RELNTVTEVD
360 370 380 390 400
KTDLESLVKR GYTTIDEIPN TIQNQTVDVI KDVKNTLDSI SSNIKDMSQS
410 420 430 440 450
IPIEDMLLQV SHYLNNSNRY LNQELPKLEE YDSYWWLGGL IVCFLLTLIV
460 470 480 490 500
TFFFLGLLCG VFGYDKHATP TRRGCVSNTG GIFLMAGVGF GFLFCWILMI
510 520 530 540 550
LVVLTFVVGA NVEKLLCEPY ENKKLLQVLD TPYLLKEQWQ FYLSGMLFNN
560 570 580 590 600
PDINMTFEQV YRDCKRGRGI YAAFQLENVV NVSDHFNIDQ ISENINTELE
610 620 630 640 650
NLNVNIDSIE LLDNTGRKSL EDFAHSGIDT IDYSTYLKET EKSPTEVNLL
660 670 680 690 700
TFASTLEAKA NQLPEGKPKQ AFLLDVQNIR AIHQHLLPPV QQSLNTLRQS
710 720 730 740 750
VWTLQQTSNK LPEKVKKILA SLDSVQHFLT NNVSLIVIGE TKKFGKTILG
760 770 780 790 800
YFEHYLHWVF YAITEKMTSC KPMATAMDSA VNGILCGYVA DPLNLFWFGI
810 820 830 840 850
GKATVLLLPA VIIAIKLAKY YRRMDSEDVY DDVETVPMKN LEIGSNGYHK
860
DHLYGVHNPV MTSPSRY
Length:867
Mass (Da):97,113
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD442F6372552B3C8
GO
Isoform 2 (identifier: O54990-2) [UniParc]FASTAAdd to basket
Also known as: S1

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.

Show »
Length:858
Mass (Da):96,136
Checksum:iCAFCAD4C3039848D
GO
Isoform 3 (identifier: O54990-3) [UniParc]FASTAAdd to basket
Also known as: S3

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.
     833-843: VETVPMKNLEI → SSVSGMWHFTL
     844-867: Missing.

Show »
Length:834
Mass (Da):93,416
Checksum:iCAFC85B2596BAB9C
GO
Isoform 4 (identifier: O54990-4) [UniParc]FASTAAdd to basket
Also known as: S4

The sequence of this isoform differs from the canonical sequence as follows:
     94-107: Missing.
     335-360: QLPSVDRELNTVTEVDKTDLESLVKR → Q
     833-843: VETVPMKNLEI → SSVSGMWHFTL
     844-867: Missing.

Show »
Length:804
Mass (Da):89,987
Checksum:iA8C6925524AE94D5
GO
Isoform 5 (identifier: O54990-5) [UniParc]FASTAAdd to basket
Also known as: S5

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.
     335-360: QLPSVDRELNTVTEVDKTDLESLVKR → Q
     833-843: VETVPMKNLEI → SSVSGMWHFTL
     844-867: Missing.

Show »
Length:809
Mass (Da):90,577
Checksum:i1FF6FB4EF6CB7095
GO
Isoform 6 (identifier: O54990-6) [UniParc]FASTAAdd to basket
Also known as: S6

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.
     832-832: D → E
     833-867: Missing.

Show »
Length:823
Mass (Da):92,197
Checksum:iE8425D90B970938A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8G5G5E8G5_MOUSE
Prominin 1, isoform CRA_a
Prom1 mCG_124143
867Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8R056Q8R056_MOUSE
Prom1 protein
Prom1
842Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8CDK8Q8CDK8_MOUSE
Prominin-1
Prom1
827Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE50A0A0G2JE50_MOUSE
Prominin-1
Prom1
804Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3X9J8G3X9J8_MOUSE
Prominin 1, isoform CRA_g
Prom1 mCG_124143
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J0B0A0A0R4J0B0_MOUSE
Prominin-1
Prom1
809Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDH9A0A0G2JDH9_MOUSE
Prominin-1
Prom1
834Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JG30A0A0G2JG30_MOUSE
Prominin-1
Prom1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE90A0A0G2JE90_MOUSE
Prominin-1
Prom1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDS7A0A0G2JDS7_MOUSE
Prominin-1
Prom1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64S → N in AAB86715 (PubMed:9356465).Curated1
Sequence conflicti64S → N in AAM28245 (PubMed:15316084).Curated1
Sequence conflicti64S → N in AAO11840 (PubMed:15316084).Curated1
Sequence conflicti64S → N in AAO72429 (PubMed:15316084).Curated1
Sequence conflicti64S → N in AAO72430 (PubMed:15316084).Curated1
Sequence conflicti64S → N in BAC26745 (PubMed:16141072).Curated1
Sequence conflicti84K → N in AAB86715 (PubMed:9356465).Curated1
Sequence conflicti84K → N in AAM28245 (PubMed:15316084).Curated1
Sequence conflicti84K → N in AAO11840 (PubMed:15316084).Curated1
Sequence conflicti84K → N in AAO72429 (PubMed:15316084).Curated1
Sequence conflicti84K → N in AAO72430 (PubMed:15316084).Curated1
Sequence conflicti84K → N in BAC26745 (PubMed:16141072).Curated1
Sequence conflicti668P → L in AAB86715 (PubMed:9356465).Curated1
Sequence conflicti668P → L in AAM28245 (PubMed:15316084).Curated1
Sequence conflicti668P → L in AAO72429 (PubMed:15316084).Curated1
Sequence conflicti668P → L in AAO72430 (PubMed:15316084).Curated1
Sequence conflicti668P → L in BAC26745 (PubMed:16141072).Curated1
Sequence conflicti844G → D in AAB86715 (PubMed:9356465).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04000594 – 107Missing in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_04000694 – 102Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 3 Publications9
Alternative sequenceiVSP_040007335 – 360QLPSV…SLVKR → Q in isoform 4 and isoform 5. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_040008832D → E in isoform 6. 1 Publication1
Alternative sequenceiVSP_040009833 – 867Missing in isoform 6. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_040010833 – 843VETVPMKNLEI → SSVSGMWHFTL in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_040011844 – 867Missing in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF039663 mRNA Translation: AAB96916.1
AF026269 mRNA Translation: AAB86715.1
AF305215 mRNA Translation: AAO11840.1
AY099088 mRNA Translation: AAM28245.1
AY223521 mRNA Translation: AAO72429.1
AY223522 mRNA Translation: AAO72430.1
AK030027 mRNA Translation: BAC26745.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39082.1 [O54990-2]
CCDS51491.1 [O54990-5]
CCDS51493.1 [O54990-3]
CCDS51494.1 [O54990-1]
CCDS80275.1 [O54990-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08881

NCBI Reference Sequences

More...
RefSeqi
NP_001157050.1, NM_001163578.1
NP_001157053.1, NM_001163581.1
NP_001157054.1, NM_001163582.1
NP_001157055.1, NM_001163583.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.6250

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19126

UCSC genome browser

More...
UCSCi
uc008xii.1 mouse [O54990-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039663 mRNA Translation: AAB96916.1
AF026269 mRNA Translation: AAB86715.1
AF305215 mRNA Translation: AAO11840.1
AY099088 mRNA Translation: AAM28245.1
AY223521 mRNA Translation: AAO72429.1
AY223522 mRNA Translation: AAO72430.1
AK030027 mRNA Translation: BAC26745.1
CCDSiCCDS39082.1 [O54990-2]
CCDS51491.1 [O54990-5]
CCDS51493.1 [O54990-3]
CCDS51494.1 [O54990-1]
CCDS80275.1 [O54990-4]
PIRiT08881
RefSeqiNP_001157050.1, NM_001163578.1
NP_001157053.1, NM_001163581.1
NP_001157054.1, NM_001163582.1
NP_001157055.1, NM_001163583.1
UniGeneiMm.6250

3D structure databases

ProteinModelPortaliO54990
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202393, 1 interactor
IntActiO54990, 1 interactor
MINTiO54990
STRINGi10090.ENSMUSP00000073751

PTM databases

iPTMnetiO54990
PhosphoSitePlusiO54990

Proteomic databases

MaxQBiO54990
PaxDbiO54990
PeptideAtlasiO54990
PRIDEiO54990

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19126
KEGGimmu:19126
UCSCiuc008xii.1 mouse [O54990-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8842
MGIiMGI:1100886 Prom1

Phylogenomic databases

eggNOGiKOG4331 Eukaryota
ENOG410XRG0 LUCA
HOGENOMiHOG000115704
HOVERGENiHBG053690
InParanoidiO54990
KOiK06532
PhylomeDBiO54990

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Prom1 mouse

Protein Ontology

More...
PROi
PR:O54990

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_PROM1

Family and domain databases

InterProiView protein in InterPro
IPR008795 Prominin
PANTHERiPTHR22730 PTHR22730, 1 hit
PfamiView protein in Pfam
PF05478 Prominin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROM1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O54990
Secondary accession number(s): O35408
, Q80XB2, Q80XB3, Q80XB6, Q8BH12
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again