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Protein

STE20-like serine/threonine-protein kinase

Gene

Slk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates apoptosis and actin stress fiber dissolution.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATPPROSITE-ProRule annotation1
Active sitei155Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-like serine/threonine-protein kinase (EC:2.7.11.1)
Short name:
STE20-like kinase
Short name:
mSLK
Alternative name(s):
Etk4
STE20-related kinase SMAK
STE20-related serine/threonine-protein kinase
Short name:
STE20-related kinase
Serine/threonine-protein kinase 2
Gene namesi
Name:Slk
Synonyms:Kiaa0204, Stk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:103241 Slk

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi436D → N: No change in caspase-3-induced cleavage product. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2176844

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332401 – 1233STE20-like serine/threonine-protein kinaseAdd BLAST1233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei183PhosphothreonineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei340PhosphoserineBy similarity1
Modified residuei341PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei372PhosphoserineBy similarity1
Modified residuei543PhosphoserineCombined sources1
Modified residuei561PhosphoserineBy similarity1
Modified residuei566PhosphoserineBy similarity1
Modified residuei643PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei775PhosphoserineBy similarity1
Modified residuei777PhosphoserineCombined sources1
Modified residuei812PhosphothreonineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Modified residuei1095PhosphothreonineBy similarity1

Post-translational modificationi

Proteolytically cleaved by caspase-3.1 Publication
Autophosphorylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei436 – 437Cleavage; by caspase-3Curated2

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO54988
PaxDbiO54988
PeptideAtlasiO54988
PRIDEiO54988

PTM databases

iPTMnetiO54988
PhosphoSitePlusiO54988

Miscellaneous databases

PMAP-CutDBiO54988

Expressioni

Tissue specificityi

Ubiquitously expressed.3 Publications

Developmental stagei

Ubiquitously expressed from day 7 to 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000025060 Expressed in 290 organ(s), highest expression level in submandibular gland
CleanExiMM_SLK
ExpressionAtlasiO54988 baseline and differential
GenevisibleiO54988 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203546, 1 interactor
IntActiO54988, 2 interactors
MINTiO54988
STRINGi10090.ENSMUSP00000049977

Structurei

3D structure databases

ProteinModelPortaliO54988
SMRiO54988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 292Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini873 – 908UVRPROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili824 – 1067Sequence analysisAdd BLAST244
Coiled coili1107 – 1181Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 19Poly-Lys4
Compositional biasi302 – 681Glu-richAdd BLAST380

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0579 Eukaryota
ENOG410XPQN LUCA
GeneTreeiENSGT00930000150827
HOGENOMiHOG000236268
HOVERGENiHBG052712
InParanoidiO54988
KOiK08836
OMAiKNVDSRW
OrthoDBiEOG091G01Y1
PhylomeDBiO54988
TreeFamiTF351445

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR022165 PKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF12474 PKK, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50151 UVR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O54988-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK
60 70 80 90 100
AQNKETNVLA AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY
110 120 130 140 150
ENNLWILIEF CAGGAVDAVM LELERPLTES QIQVVCKQTL EALNYLHDNK
160 170 180 190 200
IIHRDLKAGN ILFTLDGDIK LADFGVSAKN TRTIQRRDSF IGTPYWMAPE
210 220 230 240 250
VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP MRVLLKIAKS
260 270 280 290 300
EPPTLAQPSK WSSNFKDFLR KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV
310 320 330 340 350
RELIAEAKAE VTEEVEDGKE EDEEEEAENA LPIPANKRAS SDLSIASSEE
360 370 380 390 400
DKLSQNACIL ESVSERTEQS TSEDKFSNKI LNEKPTTDGP EKAVDEHASD
410 420 430 440 450
VNLETGAELN DQTVGIHENG REKKRPKLEN LPDTQDQQTV DVNSVSEENE
460 470 480 490 500
NNRVTLETNT DCLKPEEDRN KENQETLESK LIQSEEINDT HIQTMDLVSQ
510 520 530 540 550
ETGEKEADFQ AVDNEVGLTK EETQEKLGKD GTAQKVITSD RSSEVGTDEA
560 570 580 590 600
LDDTQKAAEL SKAAQSGEGD EALAPTQTLA EKPTEGPEAG GAEEEPPGGE
610 620 630 640 650
RVEDKQPEQQ PAVCEAEGQL TSTSETTRAT LEQPETDEVE QVSESNSIEE
660 670 680 690 700
LERLVVTGAE ARALGSEGEA AATEVDLERK ENAQKVPVKA ESQAPAASQP
710 720 730 740 750
SEPHPVLIPS ININSETTEN KEEMGALPKP ETILPPEPEH EKGNDTDSGT
760 770 780 790 800
GSTVENSSGD LNLSISSFLS KAKDSGSVSL QETRRQKKTL KKTRKFIVDG
810 820 830 840 850
VEVSVTTSKI VTDSDSKTEE LRFLRRQELR ELRLLQKEEQ RAQQQLNGKL
860 870 880 890 900
QQQREQIFRR FEQEMLSKKR QYDQEIENLE KQQKQTIERL EQEHTNRLRD
910 920 930 940 950
EAKRIKGEQE KELSKFQNVL KNRKKEVMNE VEKAPRELRR ELTKRRKEEL
960 970 980 990 1000
AQSQHAQEQE FVQKQQQELD GSLKKIIQQQ KAELANIERE CLNNKQQLMR
1010 1020 1030 1040 1050
AREAAIWELE ERHLQEKHQL LKQQLKDQYF MQRHQLLKRH EKETEQMQRY
1060 1070 1080 1090 1100
NQRLIEELKN RQTQERARLP KIQRSEAKTR MAMFKKSLRI NSTATPDQDR
1110 1120 1130 1140 1150
EKIKQFAAQE EKRQKNERMA QHQKHESQMR DLQLQCEANV RELHQLQNEK
1160 1170 1180 1190 1200
CHLLVEHETQ KLKELDEEHS QELKEWREKL RPRKKTLEEE FARKLQEQEV
1210 1220 1230
FFKMTGESEC LNPSAQSRIS KFYPIPTLHS TGS
Length:1,233
Mass (Da):141,457
Last modified:May 2, 2006 - v2
Checksum:iB1A5230666C58A73
GO
Isoform 2 (identifier: O54988-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     927-957: Missing.

Show »
Length:1,202
Mass (Da):137,713
Checksum:i9F4C78A4C31F4AB2
GO

Sequence cautioni

The sequence BAC65500 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164T → N (PubMed:8346215).Curated1
Sequence conflicti574A → V in AAB96682 (PubMed:9808774).Curated1
Sequence conflicti1098Q → K in BAC29874 (PubMed:10611247).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018101927 – 957Missing in isoform 2. 2 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039574 mRNA Translation: AAB96682.1
AF112855 mRNA Translation: AAD28717.1
AK037798 mRNA Translation: BAC29874.1
AK122218 mRNA Translation: BAC65500.1 Different initiation.
BC131675 mRNA Translation: AAI31676.1
AK029491 mRNA Translation: BAC26474.1
CCDSiCCDS38017.1 [O54988-1]
CCDS50465.1 [O54988-2]
PIRiT14157
RefSeqiNP_001158111.1, NM_001164639.1 [O54988-2]
NP_033315.2, NM_009289.3 [O54988-1]
UniGeneiMm.281011

Genome annotation databases

EnsembliENSMUST00000026043; ENSMUSP00000026043; ENSMUSG00000025060 [O54988-2]
ENSMUST00000051691; ENSMUSP00000049977; ENSMUSG00000025060 [O54988-1]
GeneIDi20874
KEGGimmu:20874
UCSCiuc008hvf.2 mouse [O54988-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039574 mRNA Translation: AAB96682.1
AF112855 mRNA Translation: AAD28717.1
AK037798 mRNA Translation: BAC29874.1
AK122218 mRNA Translation: BAC65500.1 Different initiation.
BC131675 mRNA Translation: AAI31676.1
AK029491 mRNA Translation: BAC26474.1
CCDSiCCDS38017.1 [O54988-1]
CCDS50465.1 [O54988-2]
PIRiT14157
RefSeqiNP_001158111.1, NM_001164639.1 [O54988-2]
NP_033315.2, NM_009289.3 [O54988-1]
UniGeneiMm.281011

3D structure databases

ProteinModelPortaliO54988
SMRiO54988
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203546, 1 interactor
IntActiO54988, 2 interactors
MINTiO54988
STRINGi10090.ENSMUSP00000049977

Chemistry databases

ChEMBLiCHEMBL2176844

PTM databases

iPTMnetiO54988
PhosphoSitePlusiO54988

Proteomic databases

MaxQBiO54988
PaxDbiO54988
PeptideAtlasiO54988
PRIDEiO54988

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026043; ENSMUSP00000026043; ENSMUSG00000025060 [O54988-2]
ENSMUST00000051691; ENSMUSP00000049977; ENSMUSG00000025060 [O54988-1]
GeneIDi20874
KEGGimmu:20874
UCSCiuc008hvf.2 mouse [O54988-1]

Organism-specific databases

CTDi9748
MGIiMGI:103241 Slk
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0579 Eukaryota
ENOG410XPQN LUCA
GeneTreeiENSGT00930000150827
HOGENOMiHOG000236268
HOVERGENiHBG052712
InParanoidiO54988
KOiK08836
OMAiKNVDSRW
OrthoDBiEOG091G01Y1
PhylomeDBiO54988
TreeFamiTF351445

Miscellaneous databases

PMAP-CutDBiO54988
PROiPR:O54988
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025060 Expressed in 290 organ(s), highest expression level in submandibular gland
CleanExiMM_SLK
ExpressionAtlasiO54988 baseline and differential
GenevisibleiO54988 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR022165 PKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF12474 PKK, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50151 UVR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLK_MOUSE
AccessioniPrimary (citable) accession number: O54988
Secondary accession number(s): A2RRK4
, Q80U65, Q8CAU2, Q8CDW2, Q9WU41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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