Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ketimine reductase mu-crystallin

Gene

Crym

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity).By similarity

Catalytic activityi

Thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H.

Cofactori

NAD+By similarity, NADP+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167NADPBy similarity1
Binding sitei168NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 147NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-MMU-71064 Lysine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Ketimine reductase mu-crystallin (EC:1.5.1.25)
Alternative name(s):
NADP-regulated thyroid-hormone-binding protein
Gene namesi
Name:Crym
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:102675 Crym

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002006791 – 313Ketimine reductase mu-crystallinAdd BLAST313

Proteomic databases

PaxDbiO54983
PeptideAtlasiO54983
PRIDEiO54983

PTM databases

iPTMnetiO54983
PhosphoSitePlusiO54983

Expressioni

Gene expression databases

BgeeiENSMUSG00000030905 Expressed in 218 organ(s), highest expression level in stria vascularis of cochlear duct
CleanExiMM_CRYM
ExpressionAtlasiO54983 baseline and differential
GenevisibleiO54983 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198923, 1 interactor
IntActiO54983, 4 interactors
MINTiO54983
STRINGi10090.ENSMUSP00000033198

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO54983
SMRiO54983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3007 Eukaryota
COG2423 LUCA
GeneTreeiENSGT00390000000237
HOGENOMiHOG000137263
HOVERGENiHBG005408
InParanoidiO54983
KOiK18258
OMAiHTHINAM
OrthoDBiEOG091G0NR8
PhylomeDBiO54983
TreeFamiTF105309

Family and domain databases

Gene3Di3.30.1780.10, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR003462 ODC_Mu_crystall
IPR023401 ODC_N
PANTHERiPTHR13812 PTHR13812, 1 hit
PfamiView protein in Pfam
PF02423 OCD_Mu_crystall, 1 hit
PIRSFiPIRSF001439 CryM, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

O54983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRAPAFLSA EEVQDHLRSS SLLIPPLEAA LANFSKGPDG GVMQPVRTVV
60 70 80 90 100
PVAKHRGFLG VMPAYSAAED ALTTKLVTFY EGHSNTAVPS HQASVLLFDP
110 120 130 140 150
SNGSLLAVMD GNVITAKRTA AVSAIATKLL KPPGSDVLCI LGAGVQAYSH
160 170 180 190 200
YEIFTEQFSF KEVRMWNRTR ENAEKFASTV QGDVRVCSSV QEAVTGADVI
210 220 230 240 250
ITVTMATEPI LFGEWVKPGA HINAVGASRP DWRELDDELM RQAVLYVDSR
260 270 280 290 300
EAALKESGDV LLSGADIFAE LGEVISGAKP AHCEKTTVFK SLGMAVEDLV
310
AAKLVYDSWS SGK
Length:313
Mass (Da):33,523
Last modified:June 1, 1998 - v1
Checksum:i0898EDA9E2D34C83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039391 mRNA Translation: AAB94770.1
BC045159 mRNA Translation: AAH45159.1
CCDSiCCDS21794.1
RefSeqiNP_057878.1, NM_016669.1
UniGeneiMm.9114

Genome annotation databases

EnsembliENSMUST00000033198; ENSMUSP00000033198; ENSMUSG00000030905
GeneIDi12971
KEGGimmu:12971
UCSCiuc009jmk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039391 mRNA Translation: AAB94770.1
BC045159 mRNA Translation: AAH45159.1
CCDSiCCDS21794.1
RefSeqiNP_057878.1, NM_016669.1
UniGeneiMm.9114

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BV8X-ray2.30A/B1-313[»]
4BV9X-ray2.19A/B1-313[»]
4BVAX-ray1.75A/B1-313[»]
ProteinModelPortaliO54983
SMRiO54983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198923, 1 interactor
IntActiO54983, 4 interactors
MINTiO54983
STRINGi10090.ENSMUSP00000033198

PTM databases

iPTMnetiO54983
PhosphoSitePlusiO54983

Proteomic databases

PaxDbiO54983
PeptideAtlasiO54983
PRIDEiO54983

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033198; ENSMUSP00000033198; ENSMUSG00000030905
GeneIDi12971
KEGGimmu:12971
UCSCiuc009jmk.1 mouse

Organism-specific databases

CTDi1428
MGIiMGI:102675 Crym

Phylogenomic databases

eggNOGiKOG3007 Eukaryota
COG2423 LUCA
GeneTreeiENSGT00390000000237
HOGENOMiHOG000137263
HOVERGENiHBG005408
InParanoidiO54983
KOiK18258
OMAiHTHINAM
OrthoDBiEOG091G0NR8
PhylomeDBiO54983
TreeFamiTF105309

Enzyme and pathway databases

ReactomeiR-MMU-71064 Lysine catabolism

Miscellaneous databases

ChiTaRSiCrym mouse
PROiPR:O54983
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030905 Expressed in 218 organ(s), highest expression level in stria vascularis of cochlear duct
CleanExiMM_CRYM
ExpressionAtlasiO54983 baseline and differential
GenevisibleiO54983 MM

Family and domain databases

Gene3Di3.30.1780.10, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR003462 ODC_Mu_crystall
IPR023401 ODC_N
PANTHERiPTHR13812 PTHR13812, 1 hit
PfamiView protein in Pfam
PF02423 OCD_Mu_crystall, 1 hit
PIRSFiPIRSF001439 CryM, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRYM_MOUSE
AccessioniPrimary (citable) accession number: O54983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again