UniProtKB - O54974 (LEG7_MOUSE)
Protein
Galectin-7
Gene
Lgals7
Organism
Mus musculus (Mouse)
Status
Functioni
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).By similarity
GO - Molecular functioni
- carbohydrate binding Source: GO_Central
- galactoside binding Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: InterPro
- negative regulation of CD4-positive, alpha-beta T cell proliferation Source: GO_Central
- negative regulation of gene expression Source: GO_Central
- negative regulation of interferon-gamma production Source: GO_Central
- positive regulation of gene expression Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: Galectin-7Short name: Gal-7 |
Gene namesi | Name:Lgals7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1316742, Lgals7 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Extracellular region or secreted
- extracellular space Source: InterPro
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076941 | 1 – 136 | Galectin-7Add BLAST | 136 |
Proteomic databases
MaxQBi | O54974 |
PeptideAtlasi | O54974 |
PRIDEi | O54974 |
PTM databases
PhosphoSitePlusi | O54974 |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000080179 |
Miscellaneous databases
RNActi | O54974, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 136 | GalectinPROSITE-ProRule annotationAdd BLAST | 131 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 76 | Beta-galactoside bindingSequence analysis | 7 |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
InParanoidi | O54974 |
PhylomeDBi | O54974 |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR030640, Galectin_7 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346:SF107, PTHR11346:SF107, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O54974-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSATHHKTSL PQGVRVGTVM RIRGLVPDQA GRFHVNLLCG EEQGADAALH
60 70 80 90 100
FNPRLDTSEV VFNTKQQGKW GREERGTGIP FQRGQPFEVL LIATEEGFKA
110 120 130
VVGDDEYLHF HHRLPPARVR LVEVGGDVQL HSLNIF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z141 | D3Z141_MOUSE | Galectin | Lgals7 | 86 | Annotation score: | ||
Q9CRB1 | Q9CRB1_MOUSE | Galectin | Lgals7 | 136 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038562 mRNA Translation: AAB92566.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038562 mRNA Translation: AAB92566.1 |
3D structure databases
SMRi | O54974 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000080179 |
PTM databases
PhosphoSitePlusi | O54974 |
Proteomic databases
MaxQBi | O54974 |
PeptideAtlasi | O54974 |
PRIDEi | O54974 |
Organism-specific databases
MGIi | MGI:1316742, Lgals7 |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
InParanoidi | O54974 |
PhylomeDBi | O54974 |
Miscellaneous databases
ChiTaRSi | Lgals7, mouse |
PROi | PR:O54974 |
RNActi | O54974, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR030640, Galectin_7 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346:SF107, PTHR11346:SF107, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LEG7_MOUSE | |
Accessioni | O54974Primary (citable) accession number: O54974 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot