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Protein

Galectin-7

Gene

Lgals7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Gene namesi
Name:Lgals7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1316742 Lgals7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769411 – 136Galectin-7Add BLAST136

Proteomic databases

MaxQBiO54974
PeptideAtlasiO54974
PRIDEiO54974

PTM databases

PhosphoSitePlusiO54974

Expressioni

Gene expression databases

CleanExiMM_LGALS7

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO54974
SMRiO54974
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 136GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 76Beta-galactoside bindingSequence analysis7

Phylogenomic databases

HOGENOMiHOG000293279
HOVERGENiHBG006255
InParanoidiO54974
PhylomeDBiO54974

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030640 Galectin_7
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF107 PTHR11346:SF107, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O54974-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATHHKTSL PQGVRVGTVM RIRGLVPDQA GRFHVNLLCG EEQGADAALH
60 70 80 90 100
FNPRLDTSEV VFNTKQQGKW GREERGTGIP FQRGQPFEVL LIATEEGFKA
110 120 130
VVGDDEYLHF HHRLPPARVR LVEVGGDVQL HSLNIF
Length:136
Mass (Da):15,173
Last modified:January 23, 2007 - v3
Checksum:i24E105BBF333692A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CRB1Q9CRB1_MOUSE
Galectin
Lgals7 mCG_2998
136Annotation score:
D3Z141D3Z141_MOUSE
Galectin
Lgals7
86Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038562 mRNA Translation: AAB92566.1
UniGeneiMm.20973

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038562 mRNA Translation: AAB92566.1
UniGeneiMm.20973

3D structure databases

ProteinModelPortaliO54974
SMRiO54974
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiO54974

Proteomic databases

MaxQBiO54974
PeptideAtlasiO54974
PRIDEiO54974

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1316742 Lgals7

Phylogenomic databases

HOGENOMiHOG000293279
HOVERGENiHBG006255
InParanoidiO54974
PhylomeDBiO54974

Miscellaneous databases

ChiTaRSiLgals7 mouse
PROiPR:O54974
SOURCEiSearch...

Gene expression databases

CleanExiMM_LGALS7

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030640 Galectin_7
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF107 PTHR11346:SF107, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEG7_MOUSE
AccessioniPrimary (citable) accession number: O54974
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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