UniProtKB - O54967 (ACK1_MOUSE)
Protein
Activated CDC42 kinase 1
Gene
Tnk2
Organism
Mus musculus (Mouse)
Status
Functioni
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.2 Publications
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 158 | ATP | 1 | |
Active sitei | 252 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 132 – 140 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- epidermal growth factor receptor binding Source: MGI
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: MGI
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein tyrosine kinase activity Source: MGI
- ubiquitin protein ligase binding Source: MGI
- WW domain binding Source: BHF-UCL
GO - Biological processi
- cell differentiation Source: GO_Central
- endocytosis Source: UniProtKB-KW
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- phosphorylation Source: UniProtKB
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- regulation of cell population proliferation Source: GO_Central
- regulation of clathrin-dependent endocytosis Source: MGI
- signal transduction Source: InterPro
- spermatid development Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Biological process | Endocytosis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Tnk2 Synonyms:Ack1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858308 Tnk2 |
Subcellular locationi
Nucleus
Plasma membrane
Endosome
Other locations
- adherens junction
- Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
- clathrin-coated vesicle By similarity
- clathrin-coated pit By similarity
Note: The Tyr-284 phosphorylated form is found both in the membrane and nucleus. Co-localizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent.
Endosome
- endosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- Grb2-EGFR complex Source: MGI
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: UniProtKB-SubCell
- axon Source: MGI
- clathrin-coated pit Source: MGI
- clathrin-coated vesicle Source: MGI
- cytoophidium Source: MGI
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- dendrite Source: MGI
- growth cone Source: MGI
- neuronal cell body Source: MGI
Keywords - Cellular componenti
Cell junction, Cell membrane, Coated pit, Cytoplasmic vesicle, Endosome, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 158 | K → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 424 | W → K: Increase in autophosphorylation activity. 1 Publication | 1 | |
Mutagenesisi | 464 | H → D: Loss of CDC42-binding and impairment of autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 650 | Y → A: Loss of interaction with NEDD4 and drastic reduction in its ubiquitination. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL2079848 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088059 | 1 – 1055 | Activated CDC42 kinase 1Add BLAST | 1055 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 113 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 284 | Phosphotyrosine; by SRC and autocatalysisBy similarity | 1 | ||
Modified residuei | 533 | Phosphotyrosine1 Publication | 1 | ||
Modified residuei | 842 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 854 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 874 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 887 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 896 | PhosphoserineBy similarity | 1 | ||
Isoform 2 (identifier: O54967-2) | |||||
Modified residuei | 518 | PhosphotyrosineCombined sources | 1 | ||
Isoform 3 (identifier: O54967-3) | |||||
Modified residuei | 518 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-533 is required for interaction with SRC and is observed during association with clathrin-coated pits (By similarity).By similarity
Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent.1 Publication
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O54967 |
MaxQBi | O54967 |
PaxDbi | O54967 |
PeptideAtlasi | O54967 |
PRIDEi | O54967 |
PTM databases
iPTMneti | O54967 |
PhosphoSitePlusi | O54967 |
Expressioni
Tissue specificityi
Ubiquitously present in all tissues tested. Highly expressed in the adult central nervous system (CNS); hippocampus, neocortex, and cerebellum, both at dendritic spines and presynaptic axon terminals. Levels are strongly increased during enhanced neural activity.3 Publications
Developmental stagei
Highly expressed at 14 dpc-16 dpc in the forebrain, in the proliferative ventricular zone of the neocortex and hippocampus, and in the cortical and hippocampal plates. Also observed in the septal area, the ganglionic eminence, and in the dorsal thalamus and hypothalamus. In the hindbrain, expressed in many nuclei in the brain stem and in the cerebellar anlage, external granule cell layer, in Purkinje cells and the deep cerebellar nuclei.2 Publications
Inductioni
Down-regulated by EGF.1 Publication
Interactioni
Subunit structurei
Homodimer. Interacts with CSPG4 (activated). Interacts with MERTK (activated); stimulates autophosphorylation. May interact (phosphorylated) with HSP90AB1; maintains kinase activity. Interacts with NPHP1. Interacts with SNX9 (via SH3 domain). Interacts with SRC (via SH2 and SH3 domain). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with BCAR1/p130cas via SH3 domains. Forms complexes with GRB2 and numerous receptor tyrosine kinases (RTK) including LTK, AXL or PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (By similarity). Interacts with CDC42. Interacts with EGFR, and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Interacts with NEDD4 (via WW3 domain). NEDD4L and EGF promote association with NEDD4.By similarity4 Publications
Binary interactionsi
GO - Molecular functioni
- epidermal growth factor receptor binding Source: MGI
- identical protein binding Source: MGI
- ubiquitin protein ligase binding Source: MGI
- WW domain binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 206174, 7 interactors |
DIPi | DIP-57223N |
IntActi | O54967, 3 interactors |
MINTi | O54967 |
STRINGi | 10090.ENSMUSP00000110777 |
Chemistry databases
BindingDBi | O54967 |
Structurei
3D structure databases
ProteinModelPortali | O54967 |
SMRi | O54967 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 385 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 388 – 448 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 454 – 466 | CRIBAdd BLAST | 13 | |
Domaini | 973 – 1013 | UBAAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 110 | SAM-like domainAdd BLAST | 110 | |
Regioni | 638 – 667 | Required for interaction with SRCAdd BLAST | 30 | |
Regioni | 647 – 650 | Required for interaction with NEDD41 Publication | 4 | |
Regioni | 748 – 891 | EBD domainAdd BLAST | 144 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 517 – 950 | Pro-richAdd BLAST | 434 |
Domaini
The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR.
The SAM-like domain is necessary for NEDD4-mediated ubiquitination. Promotes membrane localization and dimerization to allow for autophosphorylation.
The UBA domain binds both poly- and mono-ubiquitin.
Sequence similaritiesi
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG0199 Eukaryota ENOG410XPRC LUCA |
HOGENOMi | HOG000168225 |
HOVERGENi | HBG100429 |
InParanoidi | O54967 |
KOi | K08886 |
OrthoDBi | 1008736at2759 |
PhylomeDBi | O54967 |
Family and domain databases
Gene3Di | 4.10.680.10, 1 hit |
InterProi | View protein in InterPro IPR030220 Ack1 IPR037085 Cdc42-bd-like_dom_sf IPR015116 Cdc42_binding_dom-like IPR011009 Kinase-like_dom_sf IPR021619 Mig-6 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR009060 UBA-like_sf |
PANTHERi | PTHR14254:SF4 PTHR14254:SF4, 1 hit |
Pfami | View protein in Pfam PF09027 GTPase_binding, 1 hit PF11555 Inhibitor_Mig-6, 1 hit PF07714 Pkinase_Tyr, 1 hit PF14604 SH3_9, 1 hit |
PRINTSi | PR00109 TYRKINASE |
SMARTi | View protein in SMART SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit |
SUPFAMi | SSF46934 SSF46934, 1 hit SSF50044 SSF50044, 1 hit SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50002 SH3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O54967-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG
60 70 80 90 100
MGRPGQRRLW EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP SQHSQSTFRK
110 120 130 140 150
PSPTPGSLPG EGTLQSLTCL IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG
160 170 180 190 200
KTVSVAVKCL KPDVLSQPEA MDDFIREVNA MHSLDHRNLI RLYGVVLTLP
210 220 230 240 250
MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM AYLESKRFIH
260 270 280 290 300
RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE
310 320 330 340 350
SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL
360 370 380 390 400
PRPEDCPQDI YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE
410 420 430 440 450
EPDKLHIQMN DVITVIEGRA ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS
460 470 480 490 500
AQDISQPLQN SFIHTGHGDS DPRHCWGFPD RIDELYLGNP MDPPDLLSVE
510 520 530 540 550
LSTSRPTQHL GRVKREPPPR PPQPAIFTQK TTYDPVSEDP DPLSSDFKRL
560 570 580 590 600
GLRKPALPRG LWLAKPSARV PGTKADRSSG GEVTLIDFGE EPVVPTPRPC
610 620 630 640 650
APSLAQLAMD ACSLLDKTPP QSPTRALPRP LHPTPVVDWD ARPLPPPPAY
660 670 680 690 700
DDVAQDEDDF EVCSINSTLV GAGLPAGPSQ GETNYAFVPE QAQMPPALED
710 720 730 740 750
NLFLPPQGGG KPPSSVQTAE IFQALQQECM RQLQVPTGQL TPSPTPGGDD
760 770 780 790 800
KPQVPPRVPI PPRPTRPRVE LSPAPSGEEE TSRWPGPASP PRVPPREPLS
810 820 830 840 850
PQGSRTPSPL VPPGSSPLPH RLSSSPGKTM PTTQSFASDP KYATPQVIQA
860 870 880 890 900
PGPRAGPCIL PIVRDGRKVS STHYYLLPER PPYLERYQRF LREAQSPEEP
910 920 930 940 950
AALPVPPLLP PPSTPAPAAP TATVRPMPQA APDPKANFST NNSNPGARPP
960 970 980 990 1000
SLRAAARLPQ RGCPGDGQEA ARPADKVQML QAMVHGVTTE ECQAALQSHS
1010 1020 1030 1040 1050
WSVQRAAQYL KVEQLFGLGL RPRVECHKVL EMFDWNLEQA GCHLLGSCGP
AHHKR
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3X9X7 | G3X9X7_MOUSE | Activated CDC42 kinase 1 | Tnk2 mCG_130126 | 1,055 | Annotation score: | ||
D3Z3U6 | D3Z3U6_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 1,040 | Annotation score: | ||
D3Z3U5 | D3Z3U5_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 1,023 | Annotation score: | ||
A0A0R4J1L0 | A0A0R4J1L0_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 1,008 | Annotation score: | ||
D3Z3U7 | D3Z3U7_MOUSE | Activated CDC42 kinase 1 | Tnk2 mCG_130126 | 550 | Annotation score: | ||
E9PWA3 | E9PWA3_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 98 | Annotation score: | ||
E9QN61 | E9QN61_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 264 | Annotation score: | ||
E9QN60 | E9QN60_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 27 | Annotation score: | ||
E9Q5M1 | E9Q5M1_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 165 | Annotation score: | ||
A0A1Y7VLM9 | A0A1Y7VLM9_MOUSE | Activated CDC42 kinase 1 | Tnk2 | 44 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
The sequence AAH31168 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 – 58 | RR → SG in AAC04786 (Ref. 2) Curated | 2 | |
Sequence conflicti | 531 | T → P in ABG46266 (PubMed:16777958).Curated | 1 | |
Sequence conflicti | 574 | K → E in ABG46266 (PubMed:16777958).Curated | 1 | |
Sequence conflicti | 649 | A → V in AAC04786 (Ref. 2) Curated | 1 | |
Sequence conflicti | 818 | L → V in BAC40063 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 955 | A → T in AAH52421 (Ref. 2) Curated | 1 | |
Sequence conflicti | 955 | A → T in BAC40063 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008657 | 515 – 531 | REPPP…FTQKT → KP in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_008658 | 980 – 1011 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ666696 mRNA Translation: ABG46266.1 AF037260 mRNA Translation: AAC04786.1 BC031168 mRNA Translation: AAH31168.1 Sequence problems. BC052421 mRNA Translation: AAH52421.1 AK087965 mRNA Translation: BAC40063.1 |
CCDSi | CCDS37313.1 [O54967-1] CCDS49828.1 [O54967-2] |
RefSeqi | NP_001103617.1, NM_001110147.1 NP_001276372.1, NM_001289443.1 NP_001334114.1, NM_001347185.1 NP_058068.2, NM_016788.3 |
UniGenei | Mm.251115 |
Genome annotation databases
GeneIDi | 51789 |
KEGGi | mmu:51789 |
UCSCi | uc007yzc.2 mouse [O54967-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ666696 mRNA Translation: ABG46266.1 AF037260 mRNA Translation: AAC04786.1 BC031168 mRNA Translation: AAH31168.1 Sequence problems. BC052421 mRNA Translation: AAH52421.1 AK087965 mRNA Translation: BAC40063.1 |
CCDSi | CCDS37313.1 [O54967-1] CCDS49828.1 [O54967-2] |
RefSeqi | NP_001103617.1, NM_001110147.1 NP_001276372.1, NM_001289443.1 NP_001334114.1, NM_001347185.1 NP_058068.2, NM_016788.3 |
UniGenei | Mm.251115 |
3D structure databases
ProteinModelPortali | O54967 |
SMRi | O54967 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 206174, 7 interactors |
DIPi | DIP-57223N |
IntActi | O54967, 3 interactors |
MINTi | O54967 |
STRINGi | 10090.ENSMUSP00000110777 |
Chemistry databases
BindingDBi | O54967 |
ChEMBLi | CHEMBL2079848 |
PTM databases
iPTMneti | O54967 |
PhosphoSitePlusi | O54967 |
Proteomic databases
jPOSTi | O54967 |
MaxQBi | O54967 |
PaxDbi | O54967 |
PeptideAtlasi | O54967 |
PRIDEi | O54967 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
GeneIDi | 51789 |
KEGGi | mmu:51789 |
UCSCi | uc007yzc.2 mouse [O54967-2] |
Organism-specific databases
CTDi | 10188 |
MGIi | MGI:1858308 Tnk2 |
Phylogenomic databases
eggNOGi | KOG0199 Eukaryota ENOG410XPRC LUCA |
HOGENOMi | HOG000168225 |
HOVERGENi | HBG100429 |
InParanoidi | O54967 |
KOi | K08886 |
OrthoDBi | 1008736at2759 |
PhylomeDBi | O54967 |
Miscellaneous databases
ChiTaRSi | Tnk2 mouse |
PROi | PR:O54967 |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 4.10.680.10, 1 hit |
InterProi | View protein in InterPro IPR030220 Ack1 IPR037085 Cdc42-bd-like_dom_sf IPR015116 Cdc42_binding_dom-like IPR011009 Kinase-like_dom_sf IPR021619 Mig-6 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR009060 UBA-like_sf |
PANTHERi | PTHR14254:SF4 PTHR14254:SF4, 1 hit |
Pfami | View protein in Pfam PF09027 GTPase_binding, 1 hit PF11555 Inhibitor_Mig-6, 1 hit PF07714 Pkinase_Tyr, 1 hit PF14604 SH3_9, 1 hit |
PRINTSi | PR00109 TYRKINASE |
SMARTi | View protein in SMART SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit |
SUPFAMi | SSF46934 SSF46934, 1 hit SSF50044 SSF50044, 1 hit SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50002 SH3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ACK1_MOUSE | |
Accessioni | O54967Primary (citable) accession number: O54967 Secondary accession number(s): Q0Z844, Q8C2U0, Q8K0K4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | December 4, 2007 | |
Last modified: | February 13, 2019 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot