UniProtKB - O54947 (HAVR1_RAT)
Hepatitis A virus cellular receptor 1 homolog
Havcr1
Functioni
Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity).
As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity).
Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation (By similarity).
May play a role in kidney injury and repair (By similarity).
By similarityGO - Molecular functioni
- phosphatidylserine binding Source: RGD
- virus receptor activity Source: RGD
GO - Biological processi
- phagocytosis, engulfment Source: RGD
- positive regulation of mast cell activation Source: RGD
- response to antibiotic Source: RGD
- response to lipopolysaccharide Source: RGD
- response to mycotoxin Source: RGD
- response to nutrient Source: RGD
- response to testosterone Source: RGD
- response to wounding Source: RGD
- response to xenobiotic stimulus Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: Hepatitis A virus cellular receptor 1 homologShort name: HAVcr-1 Alternative name(s): Kidney injury molecule 1 Short name: KIM-1 T cell immunoglobulin and mucin domain-containing protein 1 Short name: TIMD-1 CD_antigen: CD365 |
Gene namesi | Name:Havcr1 Synonyms:Kim1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708425, Havcr1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Extracellular region or secreted
- extracellular space Source: RGD
Plasma Membrane
- apical plasma membrane Source: RGD
Other locations
- brush border Source: RGD
- cell surface Source: RGD
- cytoplasm Source: RGD
- integral component of membrane Source: UniProtKB-KW
- motile cilium Source: RGD
- phagocytic vesicle Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 235 | ExtracellularSequence analysisAdd BLAST | 214 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 307 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000014983 | 22 – 307 | Hepatitis A virus cellular receptor 1 homologAdd BLAST | 286 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 108 | PROSITE-ProRule annotation | ||
Disulfide bondi | 49 ↔ 60 | By similarity | ||
Disulfide bondi | 55 ↔ 107 | By similarity | ||
Glycosylationi | 206 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O54947 |
PTM databases
GlyGeni | O54947, 1 site |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with STAM.
Interacts with SELPLG.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009573 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 124 | Ig-like V-typeAdd BLAST | 103 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 177 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 140 – 177 | Polar residuesSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S454, Eukaryota |
InParanoidi | O54947 |
OrthoDBi | 1147868at2759 |
PhylomeDBi | O54947 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MVQLQVFISG LLLLLPGSVD SYEVVKGVVG HPVTIPCTYS TRGGITTTCW
60 70 80 90 100
GRGQCPYSSC QNILIWTNGY QVTYRSSGRY NIKGRISEGD VSLTIENSVD
110 120 130 140 150
SDSGLYCCRV EIPGWFNDQK MTFSLEVKPE IPTSPPTRPT TTRPTTTRPT
160 170 180 190 200
TISTRSTHVP TSTRVSTSTP TPEQTQTHKP EITTFYAHET TAEVTETPSY
210 220 230 240 250
TPADWNGTVT SSEEAWNNHT VRIPLRKPQR NPTKGFYVGM SVAALLLLLL
260 270 280 290 300
ASTVVVTRYI IIRKKMGSLS FVAFHVSKSR ALQNAAIVHP RAEDNIYIIE
DRSRGAE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V6W3 | G3V6W3_RAT | Hepatitis A virus cellular receptor... | Havcr1 rCG_34401 | 307 | Annotation score: | ||
A0A8I5Y0B2 | A0A8I5Y0B2_RAT | Hepatitis A virus cellular receptor... | Havcr1 rCG_34401 | 284 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035963 mRNA Translation: AAC53546.1 BC061820 mRNA Translation: AAH61820.1 |
RefSeqi | NP_775172.1, NM_173149.2 |
Genome annotation databases
GeneIDi | 286934 |
KEGGi | rno:286934 |
UCSCi | RGD:708425, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035963 mRNA Translation: AAC53546.1 BC061820 mRNA Translation: AAH61820.1 |
RefSeqi | NP_775172.1, NM_173149.2 |
3D structure databases
AlphaFoldDBi | O54947 |
SMRi | O54947 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009573 |
PTM databases
GlyGeni | O54947, 1 site |
Proteomic databases
PaxDbi | O54947 |
Genome annotation databases
GeneIDi | 286934 |
KEGGi | rno:286934 |
UCSCi | RGD:708425, rat |
Organism-specific databases
CTDi | 26762 |
RGDi | 708425, Havcr1 |
Phylogenomic databases
eggNOGi | ENOG502S454, Eukaryota |
InParanoidi | O54947 |
OrthoDBi | 1147868at2759 |
PhylomeDBi | O54947 |
Miscellaneous databases
PROi | PR:O54947 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HAVR1_RAT | |
Accessioni | O54947Primary (citable) accession number: O54947 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families