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Protein

Hepatitis A virus cellular receptor 1 homolog

Gene

Havcr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity).By similarity

GO - Biological processi

  • phagocytosis, engulfment Source: RGD
  • response to antibiotic Source: RGD
  • response to drug Source: RGD
  • response to mycotoxin Source: RGD
  • response to nutrient Source: RGD
  • response to testosterone Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1 homolog
Short name:
HAVcr-1
Alternative name(s):
Kidney injury molecule 1
Short name:
KIM-1
T cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
CD_antigen: CD365
Gene namesi
Name:Havcr1
Synonyms:Kim1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708425 Havcr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 307CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001498322 – 307Hepatitis A virus cellular receptor 1 homologAdd BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 108PROSITE-ProRule annotation
Disulfide bondi49 ↔ 60By similarity
Disulfide bondi55 ↔ 107By similarity
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54947
PRIDEiO54947

Expressioni

Tissue specificityi

Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009573

Structurei

3D structure databases

ProteinModelPortaliO54947
SMRiO54947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 124Ig-like V-typeAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi133 – 210Thr-richAdd BLAST78

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYS0 Eukaryota
ENOG4111VB0 LUCA
HOVERGENiHBG073424
InParanoidiO54947
KOiK20413
PhylomeDBiO54947

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O54947-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQLQVFISG LLLLLPGSVD SYEVVKGVVG HPVTIPCTYS TRGGITTTCW
60 70 80 90 100
GRGQCPYSSC QNILIWTNGY QVTYRSSGRY NIKGRISEGD VSLTIENSVD
110 120 130 140 150
SDSGLYCCRV EIPGWFNDQK MTFSLEVKPE IPTSPPTRPT TTRPTTTRPT
160 170 180 190 200
TISTRSTHVP TSTRVSTSTP TPEQTQTHKP EITTFYAHET TAEVTETPSY
210 220 230 240 250
TPADWNGTVT SSEEAWNNHT VRIPLRKPQR NPTKGFYVGM SVAALLLLLL
260 270 280 290 300
ASTVVVTRYI IIRKKMGSLS FVAFHVSKSR ALQNAAIVHP RAEDNIYIIE

DRSRGAE
Length:307
Mass (Da):33,964
Last modified:June 1, 1998 - v1
Checksum:i736D1DD1F1549760
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V6W3G3V6W3_RAT
Hepatitis A virus cellular receptor...
Havcr1 rCG_34401
307Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035963 mRNA Translation: AAC53546.1
BC061820 mRNA Translation: AAH61820.1
RefSeqiNP_775172.1, NM_173149.2
UniGeneiRn.11154

Genome annotation databases

GeneIDi286934
KEGGirno:286934
UCSCiRGD:708425 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035963 mRNA Translation: AAC53546.1
BC061820 mRNA Translation: AAH61820.1
RefSeqiNP_775172.1, NM_173149.2
UniGeneiRn.11154

3D structure databases

ProteinModelPortaliO54947
SMRiO54947
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009573

Proteomic databases

PaxDbiO54947
PRIDEiO54947

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286934
KEGGirno:286934
UCSCiRGD:708425 rat

Organism-specific databases

CTDi26762
RGDi708425 Havcr1

Phylogenomic databases

eggNOGiENOG410IYS0 Eukaryota
ENOG4111VB0 LUCA
HOVERGENiHBG073424
InParanoidiO54947
KOiK20413
PhylomeDBiO54947

Miscellaneous databases

PROiPR:O54947

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHAVR1_RAT
AccessioniPrimary (citable) accession number: O54947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 1998
Last modified: October 10, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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