Hepatitis A virus cellular receptor 1 homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• phosphatidylserine binding Source: RGDInferred from sequence orthologyⁱ
  • "Structures of T cell immunoglobulin mucin protein 4 show a metal-ion-dependent ligand binding site where phosphatidylserine binds."
    Santiago C., Ballesteros A., Martinez-Munoz L., Mellado M., Kaplan G.G., Freeman G.J., Casasnovas J.M.
    Immunity 27:941-951(2007) [PubMed] [Europe PMC] [Abstract]
• virus receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus."
    Kondratowicz A.S., Lennemann N.J., Sinn P.L., Davey R.A., Hunt C.L., Moller-Tank S., Meyerholz D.K., Rennert P., Mullins R.F., Brindley M., Sandersfeld L.M., Quinn K., Weller M., McCray P.B. Jr., Chiorini J., Maury W.
    Proc. Natl. Acad. Sci. U.S.A. 108:8426-8431(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• phagocytosis, engulfment Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells."
    Ichimura T., Asseldonk E.J., Humphreys B.D., Gunaratnam L., Duffield J.S., Bonventre J.V.
    J. Clin. Invest. 118:1657-1668(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mast cell activation Source: RGDInferred from sequence orthologyⁱ
  • "TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury."
    Yamanishi Y., Kitaura J., Izawa K., Kaitani A., Komeno Y., Nakamura M., Yamazaki S., Enomoto Y., Oki T., Akiba H., Abe T., Komori T., Morikawa Y., Kiyonari H., Takai T., Okumura K., Kitamura T.
    J. Exp. Med. 207:1501-1511(2010) [PubMed] [Europe PMC] [Abstract]
• response to antibiotic Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine."
    Zhang J., Goering P.L., Espandiari P., Shaw M., Bonventre J.V., Vaidya V.S., Brown R.P., Keenan J., Kilty C.G., Sadrieh N., Hanig J.P.
    Toxicol Pathol 37:629-643(2009) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine."
    Zhang J., Goering P.L., Espandiari P., Shaw M., Bonventre J.V., Vaidya V.S., Brown R.P., Keenan J., Kilty C.G., Sadrieh N., Hanig J.P.
    Toxicol Pathol 37:629-643(2009) [PubMed] [Europe PMC] [Abstract]
• response to mycotoxin Source: RGDInferred from expression patternⁱ
  • "Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro."
    Rached E., Hoffmann D., Blumbach K., Weber K., Dekant W., Mally A.
    Toxicol. Sci. 103:371-381(2008) [PubMed] [Europe PMC] [Abstract]
• response to nutrient Source: RGDInferred from expression patternⁱ
  • "Renoprotective mechanisms of soy protein intake in the obese Zucker rat."
    Trujillo J., Cruz C., Tovar A., Vaidya V., Zambrano E., Bonventre J.V., Gamba G., Torres N., Bobadilla N.A.
    Am. J. Physiol. Renal Physiol. 295:F1574-82(2008) [PubMed] [Europe PMC] [Abstract]
• response to testosterone Source: RGDInferred from expression patternⁱ
  • "Protective role of testosterone in ischemia-reperfusion-induced acute kidney injury."
    Soljancic A., Ruiz A.L., Chandrashekar K., Maranon R., Liu R., Reckelhoff J.F., Juncos L.A.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 304:R951-8(2013) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MVQLQVFISG LLLLLPGSVD SYEVVKGVVG HPVTIPCTYS TRGGITTTCW 
        60         70         80         90        100
GRGQCPYSSC QNILIWTNGY QVTYRSSGRY NIKGRISEGD VSLTIENSVD 
       110        120        130        140        150
SDSGLYCCRV EIPGWFNDQK MTFSLEVKPE IPTSPPTRPT TTRPTTTRPT 
       160        170        180        190        200
TISTRSTHVP TSTRVSTSTP TPEQTQTHKP EITTFYAHET TAEVTETPSY 
       210        220        230        240        250
TPADWNGTVT SSEEAWNNHT VRIPLRKPQR NPTKGFYVGM SVAALLLLLL 
       260        270        280        290        300
ASTVVVTRYI IIRKKMGSLS FVAFHVSKSR ALQNAAIVHP RAEDNIYIIE 

DRSRGAE                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families