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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Gene

Bnip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins (By similarity).By similarity

GO - Molecular functioni

  • exopolyphosphatase activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Gene namesi
Name:Bnip2
Synonyms:Nip2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109327 Bnip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649621 – 326BCL2/adenovirus E1B 19 kDa protein-interacting protein 2Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei87PhosphothreonineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei114PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO54940
MaxQBiO54940
PaxDbiO54940
PRIDEiO54940

PTM databases

iPTMnetiO54940
PhosphoSitePlusiO54940

Expressioni

Gene expression databases

BgeeiENSMUSG00000011958 Expressed in 283 organ(s), highest expression level in ascending aorta
CleanExiMM_BNIP2
ExpressionAtlasiO54940 baseline and differential
GenevisibleiO54940 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034754

Structurei

3D structure databases

ProteinModelPortaliO54940
SMRiO54940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 304CRAL-TRIOPROSITE-ProRule annotationAdd BLAST158

Phylogenomic databases

eggNOGiENOG410IFPU Eukaryota
ENOG410YCZE LUCA
GeneTreeiENSGT00420000029688
HOGENOMiHOG000230952
HOVERGENiHBG054692
InParanoidiO54940
KOiK18448
TreeFamiTF324164

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR022181 Bcl2-/adenovirus-E1B
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
PfamiView protein in Pfam
PF12496 BNIP2, 1 hit
PF13716 CRAL_TRIO_2, 1 hit
SMARTiView protein in SMART
SM00516 SEC14, 1 hit
SUPFAMiSSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O54940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGVELKEEW QDEDFPIPLP EDDSIEADTL DGTDPDRQPG SLEVNGNKVR
60 70 80 90 100
KKLMAPDISL TLDPGEDSLW SDDLDEAGEV DLEGLDTPSE NSDEFEWEDD
110 120 130 140 150
LPKPKTTEVI RKGSITEYTA TEEKGDGRRW RMFRIGEQDH RVDMKAIEPY
160 170 180 190 200
KKVISHGGYY GDGLNAIVVF AVCFMPESGQ PNYRYLMDNL FKYVIGTLEL
210 220 230 240 250
LVAENYMIIY LNGATTRRKM PSLGWLRRCY QQIDRRLRKN LKSLIIVHPS
260 270 280 290 300
WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQYE
310 320
EEKFKKRQKR VDQELNGKQE PPKSEQ
Length:326
Mass (Da):37,769
Last modified:July 27, 2011 - v2
Checksum:iED9CA74520E2913B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91VL0Q91VL0_MOUSE
BCL2/adenovirus E1B 19 kDa protein-...
Bnip2 BNIP2alpha, mCG_2934
314Annotation score:
G5E8U9G5E8U9_MOUSE
BCL2/adenovirus E1B 19 kDa protein-...
Bnip2 mCG_2934
348Annotation score:
F6VF29F6VF29_MOUSE
BCL2/adenovirus E1B 19 kDa protein-...
Bnip2
86Annotation score:
D6RE50D6RE50_MOUSE
BCL2/adenovirus E1B 19 kDa protein-...
Bnip2
107Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67D → G in AAC04329 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035207 mRNA Translation: AAC04329.1
AF400107 mRNA Translation: AAM76082.1
AY591758 mRNA Translation: AAT92040.1
AK054288 mRNA Translation: BAC35718.1
CH466522 Genomic DNA Translation: EDL26178.1
CCDSiCCDS23319.1
RefSeqiNP_058067.2, NM_016787.4
UniGeneiMm.159777

Genome annotation databases

EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958
GeneIDi12175
KEGGimmu:12175
UCSCiuc009qno.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035207 mRNA Translation: AAC04329.1
AF400107 mRNA Translation: AAM76082.1
AY591758 mRNA Translation: AAT92040.1
AK054288 mRNA Translation: BAC35718.1
CH466522 Genomic DNA Translation: EDL26178.1
CCDSiCCDS23319.1
RefSeqiNP_058067.2, NM_016787.4
UniGeneiMm.159777

3D structure databases

ProteinModelPortaliO54940
SMRiO54940
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034754

PTM databases

iPTMnetiO54940
PhosphoSitePlusiO54940

Proteomic databases

EPDiO54940
MaxQBiO54940
PaxDbiO54940
PRIDEiO54940

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958
GeneIDi12175
KEGGimmu:12175
UCSCiuc009qno.3 mouse

Organism-specific databases

CTDi663
MGIiMGI:109327 Bnip2

Phylogenomic databases

eggNOGiENOG410IFPU Eukaryota
ENOG410YCZE LUCA
GeneTreeiENSGT00420000029688
HOGENOMiHOG000230952
HOVERGENiHBG054692
InParanoidiO54940
KOiK18448
TreeFamiTF324164

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Miscellaneous databases

ChiTaRSiBnip2 mouse
PROiPR:O54940
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011958 Expressed in 283 organ(s), highest expression level in ascending aorta
CleanExiMM_BNIP2
ExpressionAtlasiO54940 baseline and differential
GenevisibleiO54940 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR022181 Bcl2-/adenovirus-E1B
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
PfamiView protein in Pfam
PF12496 BNIP2, 1 hit
PF13716 CRAL_TRIO_2, 1 hit
SMARTiView protein in SMART
SM00516 SEC14, 1 hit
SUPFAMiSSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBNIP2_MOUSE
AccessioniPrimary (citable) accession number: O54940
Secondary accession number(s): Q8K4H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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