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Entry version 152 (08 May 2019)
Sequence version 3 (28 Jul 2009)
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Protein

A-kinase anchor protein 2

Gene

Akap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 2
Short name:
AKAP-2
Alternative name(s):
AKAP expressed in kidney and lung
Short name:
AKAP-KL
Protein kinase A-anchoring protein 2
Short name:
PRKA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akap2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1306795 Akap2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi590A → S: No effect on binding to RII. 1 Publication1
Mutagenesisi598I → A: Reduces binding to RII. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000206571 – 893A-kinase anchor protein 2Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei122PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei357PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei486PhosphoserineBy similarity1
Modified residuei538PhosphoserineBy similarity1
Modified residuei547PhosphothreonineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei768PhosphoserineBy similarity1
Modified residuei799PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O54931

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O54931

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O54931

PeptideAtlas

More...
PeptideAtlasi
O54931

PRoteomics IDEntifications database

More...
PRIDEi
O54931

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O54931

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O54931

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung and weakly in thymus and cerebellum. Little or no expression in liver, heart and cerebral cortex. All isoforms are expressed in lung, but KL2A and KL2B isoforms are the principal isoforms in cerebellum.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038729 Expressed in 33 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O54931 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O54931 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Prkar2aP123673EBI-645828,EBI-645747

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198049, 2 interactors

Protein interaction database and analysis system

More...
IntActi
O54931, 4 interactors

Molecular INTeraction database

More...
MINTi
O54931

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000117466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni586 – 599PKA-RII subunit binding domainAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili255 – 316Sequence analysisAdd BLAST62
Coiled coili729 – 766Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi274 – 311Gln-richAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG9A Eukaryota
ENOG410ZMFZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231745

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O54931

KEGG Orthology (KO)

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KOi
K16519

Database of Orthologous Groups

More...
OrthoDBi
604893at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O54931

TreeFam database of animal gene trees

More...
TreeFami
TF105402

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029304 AKAP2_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15304 AKAP2_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O54931-1) [UniParc]FASTAAdd to basket
Also known as: KL1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIGVSVAEC KSVPGVTSTP HSKDHSSPFY SPSHNGLLAD HHESLDNDVA
60 70 80 90 100
REIQYLDEVL EANCCDSSVD GTYNGISSPE PGAAILVSSL GSPAHSVTEA
110 120 130 140 150
EPTEKASGRQ VPPHIELSRS PSDRMAEGER ANGHSTDQPQ DLLGNSLQAP
160 170 180 190 200
ASPSSSTSSH CSSRDGEFTL TTLKKEAKFE LRAFHEDKKP SKLFEEDERE
210 220 230 240 250
KEQFCVRKVR PSEEMIELEK ERRELIRSQA VKKNPGIAAK WWNPPQEKTI
260 270 280 290 300
EEQLDEEHLE SHRKYKERKE KRAQQEQLQL QQQQQQQLQQ QQLQQQQLQQ
310 320 330 340 350
QQLQQQLQQQ QLSTSQPCTA PAAHKHLDGI EHTKEDVVTE QIDFSAARKQ
360 370 380 390 400
FQLMENSRQT LAKGQSTPRL FSIKPYYKPL GSIHSDKPPT ILRPATVGGT
410 420 430 440 450
LEDGGTQAAK EQKAPCVSES QSAGAGPANA ATQGKEGPYS EPSKRGPLSK
460 470 480 490 500
LWAEDGEFTS ARAVLTVVKD EDHGILDQFS RSVNVSLTQE ELDSGLDELS
510 520 530 540 550
VRSQDTTVLE TLSNDFSMDN ISDSGASNET PSALQENSLA DFSLPQTPQT
560 570 580 590 600
DNPSEGREGV SKSFSDHGFY SPSSTLGDSP SVDDPLEYQA GLLVQNAIQQ
610 620 630 640 650
AIAEQVDKAE AHTSKEGSEQ QEPEATVEEA GSQTPGSEKP QGMFAPPQVS
660 670 680 690 700
SPVQEKRDIL PKNLPAEDRA LREKGPSQPP TAAQPSGPVN MEETRPEGGY
710 720 730 740 750
FSKYSEAAEL RSTASLLATQ ESDVMVGPFK LRSRKQRTLS MIEEEIRAAQ
760 770 780 790 800
EREEELKRQR QVRQSTPSPR AKNAPSLPSR TTCYKTAPGK IEKVKPPPSP
810 820 830 840 850
TTEGPSLQPD LAPEEAAGTQ RPKNLMQTLM EDYETHKSKR RERMDDSSYT
860 870 880 890
SKLLSCKVTS EVLEATRVNR RKSALALRWE AGIYANQEEE DNE
Length:893
Mass (Da):98,579
Last modified:July 28, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C9ADD7C4362EF49
GO
Isoform 2 (identifier: O54931-2) [UniParc]FASTAAdd to basket
Also known as: KL2A

The sequence of this isoform differs from the canonical sequence as follows:
     849-861: Missing.

Note: Produced by alternative splicing.
Show »
Length:880
Mass (Da):97,138
Checksum:i1CD1888BA492C55D
GO
Isoform 3 (identifier: O54931-3) [UniParc]FASTAAdd to basket
Also known as: KL3A

The sequence of this isoform differs from the canonical sequence as follows:
     790-795: KIEKVK → PGGHTG
     796-893: Missing.

Note: Produced by alternative splicing.
Show »
Length:795
Mass (Da):87,270
Checksum:i6BB58D5EABDF283A
GO
Isoform 4 (identifier: O54931-4) [UniParc]FASTAAdd to basket
Also known as: KL1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Note: Produced by alternative initiation at Met-125 of isoform KL1A.
Show »
Length:769
Mass (Da):85,517
Checksum:i6EF28D2ACAEFDB47
GO
Isoform 5 (identifier: O54931-5) [UniParc]FASTAAdd to basket
Also known as: KL2B

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.
     849-861: Missing.

Note: Produced by alternative initiation at Met-125 of isoform KL2A.
Show »
Length:756
Mass (Da):84,077
Checksum:iC30DF3CEC4058A6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2API8A2API8_MOUSE
A-kinase anchor protein 2
Akap2
921Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2APJ1A2APJ1_MOUSE
A-kinase anchor protein 2
Akap2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2API9A2API9_MOUSE
A-kinase anchor protein 2
Akap2
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC02206 differs from that shown. Reason: Frameshift at position 875.Curated
The sequence AAC02207 differs from that shown. Reason: Frameshift at position 875.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120S → I in AAC02206 (PubMed:9497389).Curated1
Sequence conflicti120S → I in AAC02207 (PubMed:9497389).Curated1
Sequence conflicti120S → I in AAC02208 (PubMed:9497389).Curated1
Sequence conflicti264K → R in AAC02206 (PubMed:9497389).Curated1
Sequence conflicti264K → R in AAC02207 (PubMed:9497389).Curated1
Sequence conflicti264K → R in AAC02208 (PubMed:9497389).Curated1
Sequence conflicti531P → T in AAC02206 (PubMed:9497389).Curated1
Sequence conflicti531P → T in AAC02207 (PubMed:9497389).Curated1
Sequence conflicti531P → T in AAC02208 (PubMed:9497389).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187761 – 124Missing in isoform 4 and isoform 5. CuratedAdd BLAST124
Alternative sequenceiVSP_004097790 – 795KIEKVK → PGGHTG in isoform 3. 1 Publication6
Alternative sequenceiVSP_004098796 – 893Missing in isoform 3. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_004099849 – 861Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF033274 mRNA Translation: AAC02206.1 Frameshift.
AF033275 mRNA Translation: AAC02207.1 Frameshift.
AF033276 mRNA Translation: AAC02208.1
AK077020 mRNA Translation: BAC36571.1
AK147420 mRNA Translation: BAE27901.1
AL840629 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS18203.1 [O54931-2]
CCDS18204.1 [O54931-1]
CCDS18205.1 [O54931-3]

Protein sequence database of the Protein Information Resource

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PIRi
T09225

NCBI Reference Sequences

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RefSeqi
NP_001030609.1, NM_001035532.2 [O54931-2]
NP_001030610.1, NM_001035533.2 [O54931-1]
NP_001291473.1, NM_001304544.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043456; ENSMUSP00000048678; ENSMUSG00000038729 [O54931-1]
ENSMUST00000098064; ENSMUSP00000095672; ENSMUSG00000038729 [O54931-2]
ENSMUST00000102902; ENSMUSP00000099966; ENSMUSG00000038729 [O54931-3]
ENSMUST00000102903; ENSMUSP00000099967; ENSMUSG00000038729 [O54931-3]
ENSMUST00000107598; ENSMUSP00000103224; ENSMUSG00000038729 [O54931-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11641
677884

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:11641
mmu:677884

UCSC genome browser

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UCSCi
uc008syj.2 mouse [O54931-2]
uc008syk.2 mouse [O54931-3]
uc008syl.2 mouse [O54931-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033274 mRNA Translation: AAC02206.1 Frameshift.
AF033275 mRNA Translation: AAC02207.1 Frameshift.
AF033276 mRNA Translation: AAC02208.1
AK077020 mRNA Translation: BAC36571.1
AK147420 mRNA Translation: BAE27901.1
AL840629 Genomic DNA No translation available.
CCDSiCCDS18203.1 [O54931-2]
CCDS18204.1 [O54931-1]
CCDS18205.1 [O54931-3]
PIRiT09225
RefSeqiNP_001030609.1, NM_001035532.2 [O54931-2]
NP_001030610.1, NM_001035533.2 [O54931-1]
NP_001291473.1, NM_001304544.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi198049, 2 interactors
IntActiO54931, 4 interactors
MINTiO54931
STRINGi10090.ENSMUSP00000117466

PTM databases

iPTMnetiO54931
PhosphoSitePlusiO54931

Proteomic databases

jPOSTiO54931
MaxQBiO54931
PaxDbiO54931
PeptideAtlasiO54931
PRIDEiO54931

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043456; ENSMUSP00000048678; ENSMUSG00000038729 [O54931-1]
ENSMUST00000098064; ENSMUSP00000095672; ENSMUSG00000038729 [O54931-2]
ENSMUST00000102902; ENSMUSP00000099966; ENSMUSG00000038729 [O54931-3]
ENSMUST00000102903; ENSMUSP00000099967; ENSMUSG00000038729 [O54931-3]
ENSMUST00000107598; ENSMUSP00000103224; ENSMUSG00000038729 [O54931-2]
GeneIDi11641
677884
KEGGimmu:11641
mmu:677884
UCSCiuc008syj.2 mouse [O54931-2]
uc008syk.2 mouse [O54931-3]
uc008syl.2 mouse [O54931-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11217
677884
MGIiMGI:1306795 Akap2

Phylogenomic databases

eggNOGiENOG410IG9A Eukaryota
ENOG410ZMFZ LUCA
GeneTreeiENSGT00930000151059
HOGENOMiHOG000231745
InParanoidiO54931
KOiK16519
OrthoDBi604893at2759
PhylomeDBiO54931
TreeFamiTF105402

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Akap2 mouse

Protein Ontology

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PROi
PR:O54931

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038729 Expressed in 33 organ(s), highest expression level in lung
ExpressionAtlasiO54931 baseline and differential
GenevisibleiO54931 MM

Family and domain databases

InterProiView protein in InterPro
IPR029304 AKAP2_C
PfamiView protein in Pfam
PF15304 AKAP2_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKAP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O54931
Secondary accession number(s): A2APJ4
, O54932, O54933, Q8C5W1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 28, 2009
Last modified: May 8, 2019
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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